Data Sheet 1_Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy.pdf by Chun-Fei Wu (22315444)

“…Objective<p>Chondrosarcoma, a malignant bone tumor, exhibits a high incidence rate. …”

DataSheet1_Dose Dependent Antimicrobial Cellular Cytotoxicity—Implications for ex vivo Diagnostics.docx by Ana Copaescu (10314533)

“…The PBMCs were stimulated for the investigated drugs at the previously published drug maximum concentration (Cmax), and concentrations 10- and 100-fold above.</p><p>Results: In a human immunodeficiency virus (HIV) negative and a positive rifampicin-associated DRESS with positive ex vivo IFN-γ ELISpot assay, use of 10- and 100-fold Cmax drug concentrations decreased spot forming units/million cells by 32–100%, and this corresponded to cell cytotoxicity of more than 40 and 20% using an LDH assay and 7-AAD cell viability staining, respectively. …”

DataSheet1_Dose Dependent Antimicrobial Cellular Cytotoxicity—Implications for ex vivo Diagnostics.docx by Ana Copaescu (10314533)

“…The PBMCs were stimulated for the investigated drugs at the previously published drug maximum concentration (Cmax), and concentrations 10- and 100-fold above.</p><p>Results: In a human immunodeficiency virus (HIV) negative and a positive rifampicin-associated DRESS with positive ex vivo IFN-γ ELISpot assay, use of 10- and 100-fold Cmax drug concentrations decreased spot forming units/million cells by 32–100%, and this corresponded to cell cytotoxicity of more than 40 and 20% using an LDH assay and 7-AAD cell viability staining, respectively. …”

Analysis of microbial alpha diversity among genotypes and their association with intestinal inflammation. by Philipp Rausch (764340)

“…(C) The bacterial species richness is (i) decreasing with increasing inflammation (<i>F</i>_1,22 = 14.2123, <i>P</i> = 0.0011; LMM), (ii) but highly predictive of inflammation with differences among <i>B4galnt2</i> genotypes (D; Chao1 <i>F</i>_1,21 = 9.8274, <i>P</i> = 0.005, <i>B6</i>: <i>F</i>_1,21 = 9.2976, <i>P</i> = 0.0061, see also <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005008#ppat.1005008.t002" target="_blank">Table 2</a>). …”

DataSheet1_Dose Dependent Antimicrobial Cellular Cytotoxicity—Implications for ex vivo Diagnostics.docx by Ana Copaescu (10314533)

“…The PBMCs were stimulated for the investigated drugs at the previously published drug maximum concentration (Cmax), and concentrations 10- and 100-fold above.</p><p>Results: In a human immunodeficiency virus (HIV) negative and a positive rifampicin-associated DRESS with positive ex vivo IFN-γ ELISpot assay, use of 10- and 100-fold Cmax drug concentrations decreased spot forming units/million cells by 32–100%, and this corresponded to cell cytotoxicity of more than 40 and 20% using an LDH assay and 7-AAD cell viability staining, respectively. …”

Image_3_Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.tif by Mingyue Li (1582399)

“…More importantly, elevated expression of regulatory molecules, such as CD244 and programmed death-1 (PD-1), on NK cells and T cells, as well as decreased serum cytotoxic effector molecules including perforin and granzyme A, were detected in patients with COVID-19. …”

Data_Sheet_1_Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia.PDF by Lelinh Duong (5932946)

“…The immune system plays a critical role in the effectiveness of many anti-cancer therapies in young hosts via tumor-specific T cells. …”

Image_2_Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.tif by Mingyue Li (1582399)

“…More importantly, elevated expression of regulatory molecules, such as CD244 and programmed death-1 (PD-1), on NK cells and T cells, as well as decreased serum cytotoxic effector molecules including perforin and granzyme A, were detected in patients with COVID-19. …”

Data_Sheet_1_First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction.docx by Lien-Cheng Hsiao (13217106)

“…</p>Methods<p>Consenting patients received the first dose of UMSC01 through IC injection 4-5 days after STEMI followed by the second dose of UMSC01 via IV infusion 2 days later. The primary endpoint was occurrence of any treatment-related adverse events and the secondary endpoint was changes of serum biomarkers and heart function by cardiac magnetic resonance imaging during a 12-month follow-up period.…”

Image_5_Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.tif by Mingyue Li (1582399)

“…More importantly, elevated expression of regulatory molecules, such as CD244 and programmed death-1 (PD-1), on NK cells and T cells, as well as decreased serum cytotoxic effector molecules including perforin and granzyme A, were detected in patients with COVID-19. …”

Image_1_Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.tif by Mingyue Li (1582399)

“…More importantly, elevated expression of regulatory molecules, such as CD244 and programmed death-1 (PD-1), on NK cells and T cells, as well as decreased serum cytotoxic effector molecules including perforin and granzyme A, were detected in patients with COVID-19. …”

Image_4_Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.tif by Mingyue Li (1582399)

“…More importantly, elevated expression of regulatory molecules, such as CD244 and programmed death-1 (PD-1), on NK cells and T cells, as well as decreased serum cytotoxic effector molecules including perforin and granzyme A, were detected in patients with COVID-19. …”

DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles by Darren W. Gray (5066456)

“…Male Holstein Friesian calves were intranasally vaccinated (Pfizer RISPOVAL^®PI3+RSV) and subsequently challenged with Bovine Parainfluenza Virus type-3 (BPI3V) via nasal inoculation. Metabolomic plasma profiling revealed that viral challenge led to a shift in acquired plasma metabolite profiles from day 2 to 20 p.i., with 26 metabolites identified whose peak intensities were significantly different following viral challenge depending on vaccination status. …”

Image_1_Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase.pdf by Ren-shi Li (6423038)

“…<p>Background: Pulmonary fibrosis (PF) is a devastating interstitial lung disease and characterized by an abnormal accumulation of extracellular matrix (ECM). …”

Image_2_Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase.pdf by Ren-shi Li (6423038)

“…<p>Background: Pulmonary fibrosis (PF) is a devastating interstitial lung disease and characterized by an abnormal accumulation of extracellular matrix (ECM). …”

Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis <i>in vitro</i> and <i>in vivo</i> by Hongrui Cui (12001906)

“…<p>Acute kidney injury (AKI) is a common complication of sepsis and increase morbidity and mortality. …”

Image_1_Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways.JPEG by Laure Campillo-Gimenez (349278)

“…NF-κB activation was determined in THP-1 cells containing a reporter plasmid. In vivo, the inflammatory potential of CPP phases was assessed with the murine air pouch model via cell analysis and production of IL-1β and CXCL1 in the exudate. …”

TIP-resistant HIV mutants face conflicting selection pressures. by Luke I. Rast (2735782)

“…At the individual-level, relative fitness represents the relative rate of expansion or contraction of HIV mutants (via the effective selection coefficient; see Eq. 97 in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004799#pcbi.1004799.s001" target="_blank">S1 Text</a>). …”

DataSheet1_Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice.PDF by Kenneth R. Hallows (14168583)

“…We hypothesized that BA could be a novel ADPKD therapy by inhibiting cyst growth, proliferation, injury, and metabolic dysregulation via ACLY inhibition and AMPK activation. …”

DataSheet2_Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice.PDF by Kenneth R. Hallows (14168583)

“…We hypothesized that BA could be a novel ADPKD therapy by inhibiting cyst growth, proliferation, injury, and metabolic dysregulation via ACLY inhibition and AMPK activation. …”