DataSheet_1_TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.pdf by Ke Ren (34504)

“…In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.…”

Table_1_Age-Specific Imbalance of Circulating Tfh Cell Subsets and Its Association With Gout-Targeted Kidney Impairment.xls by Yefei Huang (447675)

“…Objective<p>Gout is a chronic disease characterized by the deposition of monosodium urate (MSU) crystals in tissue. …”

Table 3_Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression... by Yifeng Zhang (521454)

“…</p>Results<p>We found that the proportion of Tregs significantly decreased, and Th2 cells showed a significant increase in atherosclerotic plaque compared to that in non-plaque arterial tissues. …”

Image 1_Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression... by Yifeng Zhang (521454)

“…</p>Results<p>We found that the proportion of Tregs significantly decreased, and Th2 cells showed a significant increase in atherosclerotic plaque compared to that in non-plaque arterial tissues. …”

Image_5_TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.tif by Ke Ren (34504)

“…In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.…”

Image_2_TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.tif by Ke Ren (34504)

“…In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.…”

Alkannin restrains oral squamous carcinoma cell growth, migration and invasion by regulating microRNA-9/RECK axis by Yulong Mao (5857469)

“…In conclusion, ALK restrained OSCC cells growth, migration and invasion via adjusting miR-9/RECK axis.Highlights</p><p>ALK restrains cell growth, migration and invasion in OSCC cells;</p><p>miR-9 is enhanced in OSCC tissues but is repressed by ALK in OSCC cells;</p><p>miR-9 inverts the repressive effect of ALK on CAL-27 and SCC-9 cells;</p><p>RECK is a novel target of miR-9;</p><p>ALK or RECK hinders JAK1/STAT3 and PI3K/AKT pathways in CAL-27 and SCC-9 cells;</p><p>ALK prohibits tumour formation <i>in vivo</i>.…”

Image_8_TP53-Activated lncRNA GHRLOS Regulates Cell Proliferation, Invasion, and Apoptosis of Non-Small Cell Lung Cancer by Modulating the miR-346/APC Axis.tif by Ke Ren (34504)

“…In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.…”

Impact of human sepsis on CCCTC-binding factor associated monocyte transcriptional response of Major Histocompatibility Complex II components by Benedikt Hermann Siegler (5421062)

“…These elements are bound by the DNA-binding protein CCCTC-Binding Factor (CTCF), a superordinate modulator of gene transcription. …”

<i>In vitro</i> and <i>in vivo</i> anti-inflammatory active copper(II)-lawsone complexes by Ján Vančo (490366)

“…On the other hand, all the complexes <b>1</b>–<b>7</b> decreased significantly the levels of the secreted TNF-alpha after the LPS activation of THP-1 cells, thus showing the anti-inflammatory potential <i>via</i> both NF-<i>κ</i>B moderation and by other mechanisms, such as influence on TNF-alpha transcription and/or translation and/or secretion. …”

Image_2_Two new and effective food-extracted immunomodulatory agents exhibit anti-inflammatory response activity in the hACE2 acute lung injury murine model of COVID-19.tif by Shasha Liu (1754584)

“…This study aims to investigate the effects of two food-extracted immunomodulatory agents, ajoene-enriched garlic extract (AGE) and cruciferous vegetables-extracted sulforaphane (SFN), on anti-inflammatory and immune responses in a SARS-CoV-2 acute lung injury mouse model.</p>Methods<p>In this study, we established a mouse model to mimic the SARS-CoV-2 infection acute lung injury model via intratracheal injection of polyinosinic:polycytidylic acid (poly[I:C]) and SARS-CoV-2 recombinant spike protein (SP). …”

DataSheet1_Exploration on Varying Patterns of Morphological Features and Quality of Armeniacae Semen Amarum in Rancid Process Based on Colorimeter, Electronic Nose, and GC/MS Coupl... by Yuanyang Shao (12491110)

“…Moreover, there were obvious differences in the amygdalin content and peroxide value among ASA samples with different rancidness degrees. With a higher degree of rancidness, the content of amygdalin decreased, while the peroxide value increased significantly. …”

DataSheet_1_Characterization of post-vaccination SARS-CoV-2 T cell subtypes in patients with different hematologic malignancies and treatments.zip by Roald Pfannes (15373546)

“…Patients affected by hematologic malignancies are frequently immune-compromised and show a decreased seroconversion rate compared to other cancer patients or controls. …”

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate by Weiguang Wang (296029)

“…<div><p>TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs. non-canonical pathways in cartilage is unknown because the role of Smad2 in chondrogenesis has not been investigated <i>in vivo</i>. …”

PDLB - Balance Sheet by Nguyen Linh (19516642)

“…It built out management capabilities for a much larger bank, and is currently seeing decreasing Q/Q non-interest cost, while assets and interest income are growing nicely.…”

Constructing AgCoOx with Steering Intermediate Coverage for Efficient Kinetic Promotion of Electrochemical-/Solar-Driven Water Splitting by Kaliyamoorthy Santhosh Kumar (20448663)

“…A simple wet chemical method is established to report Ag- and Co-based oxalate (Ag@CoC₂O₄) for catalyzing OER, which demands 291/241 mV (GC/NF) to reach 10 mA/cm_geo², a reduction of 50 mV compared to CoC₂O₄ with a Tafel slope of 68/60 mV dec^–1, a chronopotentiometry stability of 12/100 h, and a Faradaic efficiency of 98%. …”

Low temperature reduces byssus adhesion of highly invasive golden mussels: Influencing mechanisms and antifouling implications by Miaolian Zhang (21974951)

“…Low-temperature treatment offers a promising alternative for freshwater antifouling; however, its underlying mechanisms remain poorly understood. …”

Model of supercoiling-coupled transcription. by Boaz Goldberg (22601119)

“…<p>(A) Model setup. For transcription, we consider the following fives aspects: (1) initiation, a single step process dependent on SC; (2) elongation, which introduces positive and negative supercoils downstream and upstream respectively; it occurs at a constant rate except when stalled under extreme supercoiling levels; (3) termination, which occurs instantaneously and produces a single RNA transcript; (4) topoisomerase activities, including gyrase and TopoI; and (5) RNA degradation, which occurs via a Poisson process. …”

Image_1_Hematopoietic-Specific Deletion of Foxo1 Promotes NK Cell Specification and Proliferation.pdf by Pei Huang (1821661)

“…The reason for Foxo1 suppressing NK cell proliferation might be its direct transcription of the cell-cycle inhibitory genes, such as p21^cip1, p27^kip1, p130, Gadd45a, and Ccng2 (cyclin G2) in NK cells, supported by the evidence of decreased mRNA expression of p21^cip1, p27^kip1, p130, Gadd45a, and Ccng2 in Foxo1-deficient NK cells and direct binding of Foxo1 on their promoter region. …”

Supplemental data of Glucocorticoid Dependent Mesenchymal Cell Differentiation is Required for Perinatal Lung Morphogenesis and Lung Function by Yan Xu (6655778)

“…Red and green nodes represent ligands increased or decreased in mesenchymal GR deletion lung (Col1a2Cre;Nr3c1^fl/fl) at E18.5, respectively. …”