<i>C9orf72</i> and <i>smcr8</i> mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis by Qiang Shao (112168)

“…In contrast, <i>C9orf72</i> or <i>Smcr8</i> depletion in proliferating macrophages decreased MTORC1 signaling. Our studies causatively link C9orf72-SMCR8’s cellular functions in lysosomal degradation, exocytosis, and MTORC1 signaling with their organism-level immune regulation, suggesting cell state (proliferation vs. differentiation)-dependent regulation of MTOR signaling via lysosomes.…”

Primer sequences. by Oluwafemi Adeleke Ojo (12176981)

“…Treatment was administered for 15 successive days via oral gavage. After 15 days, the rats were evaluated for fasting blood glucose (FBG), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (MDA), hexokinase, and glucose-6-phosphatase activities. …”

Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate by Lei He (143930)

“…<p><b>Aim:</b> To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy.…”

S1 File - by Oluwafemi Adeleke Ojo (12176981)

“…Treatment was administered for 15 successive days via oral gavage. After 15 days, the rats were evaluated for fasting blood glucose (FBG), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (MDA), hexokinase, and glucose-6-phosphatase activities. …”

S1 Data - by Oluwafemi Adeleke Ojo (12176981)

“…Treatment was administered for 15 successive days via oral gavage. After 15 days, the rats were evaluated for fasting blood glucose (FBG), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (MDA), hexokinase, and glucose-6-phosphatase activities. …”

yorku.forest.oct25-2016 by Fatemah Alibrahim (3113583)

“…The data was collected through a number of methods in the forest habitat.</p> <p>The field site was located on the York University-Keele Campus on a forest habitat (43.77, -79.51) near Keele Street and York Boulevard. …”

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells by Zili Zhang (324010)

“…<p>Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. …”

Uncovering the mechanistic basis of <i>Rheum palmatum</i> L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular doc... by Wenjing He (4278625)

“…</p> <p>High-performance liquid chromatography (HPLC) established a rhubarb fingerprint to ensure quality control. …”

DataSheet_2_LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis.pdf by Huifang Wang (390338)

“…Background<p>Neuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. …”

Table_1_LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis.docx by Huifang Wang (390338)

“…Background<p>Neuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. …”

DataSheet_1_LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis.zip by Huifang Wang (390338)

“…Background<p>Neuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. …”

Sketch of the hypothetical pathway of HLB-tolerant and HLB-susceptible citrus species in response to <i>C</i>Las. by Bin Hu (122268)

“…In addition, SDEs move into cells via the Sec-dependent secretion system; SDEs such as SDE1 interact with receptor protein PLCP and suppress its activity, which weakens the citrus plant defense response [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1010071#ppat.1010071.ref107" target="_blank">107</a>]. …”

Human mesenchymal stem/stromal cells (hMSCs) increased <i>Ccl2</i> expression and reduced inflammatory responses. by Kazumichi Yagura (4537504)

“…<p><b>(A)</b> All tested chemokine and receptor primers were detected at the expected rates in mouse samples (Ms). …”

Table 1_TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis.docx by Miguel Chirivi (9677739)

“…LPS also increased the expression of EP2, a PGE₂ receptor, while simultaneously reducing EP4 content. …”

Image 1_TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis.jpeg by Miguel Chirivi (9677739)

“…LPS also increased the expression of EP2, a PGE₂ receptor, while simultaneously reducing EP4 content. …”

Table_1_CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease.docx by Igor Kudryavtsev (5741774)

“…Overall, the data obtained demonstrated that purinergic signaling was involved in the pathogenesis of aortic stenosis and calcification potentially acting via various cell types, wherein among enzymes, degrading extracellular ATP CD73 rather than CD39 played a prominent role.…”

Isoflavone-mediated radioprotection involves regulation of early endothelial cell death and inflammatory signaling in Radiation-Induced lung injury by Matthew D. Fountain (7521539)

Presentation_1_CD73 Rather Than CD39 Is Mainly Involved in Controlling Purinergic Signaling in Calcified Aortic Valve Disease.pdf by Igor Kudryavtsev (5741774)

“…Overall, the data obtained demonstrated that purinergic signaling was involved in the pathogenesis of aortic stenosis and calcification potentially acting via various cell types, wherein among enzymes, degrading extracellular ATP CD73 rather than CD39 played a prominent role.…”

Gibberellin Application at Pre-Bloom in Grapevines Down-Regulates the Expressions of <i>VvIAA9</i> and <i>VvARF7</i>, Negative Regulators of Fruit Set Initiation, during Parthenoca... by Chan Jin Jung (553523)

“…Without GA application, <i>VvIAA9, VvARF7</i>, and <i>VvARF8</i> were expressed at a relatively high level before full bloom, but decreased thereafter following pollination. …”

2-aminoethoxydipheny (2-APB) reduced pathogen-activated Ca²⁺ signaling in macrophages. by Ching-Ying Wu (3145974)

“…<p>(A) Fluorescence images of <i>O</i>. <i>tsutsugamushi</i> (OT)-infected macrophages at indicated time point with staining by Celltrackers (cytoplasm, green; OT, red) and DAPI (uncles, blue). …”