Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat synd... by Yun Yang (417125)

“…Damp-heat syndrome was induced on day 29 via intraperitoneal lipopolysaccharide (LPS) injections (1 mg/kg and 0.5 mg/kg after 4 hours). …”

Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension by Yuhee Ryu (3370769)

“…MS-275 treatment reduced aorta collagen deposition, as determined by Masson’s trichrome staining. MS-275 decreased the components of the renin angiotensin system and increased vascular relaxation of rat aortic rings via the nitric oxide (NO) pathway. …”

DataSheet_1_Sepsis causes neutrophil infiltration in muscle leading to muscle atrophy and weakness in mice.docx by Nobuto Nakanishi (8069483)

“…</p>Methods<p>Sepsis was induced in seven-week-old male C57BL/6J mice 8-12 (cecal slurry [CS] model) via intraperitoneal injection of 1 mg/g cecal slurry. …”

Data_Sheet_1_Treatment of liver fibrosis in hepatolenticular degeneration with traditional Chinese medicine: systematic review of meta-analysis, network pharmacology and molecular... by Xulong Yang (15458126)

“…The results of network pharmacological experiments and molecular dynamics simulation indicate that the three high-frequency TCMs (Rhei Radix Et Rhizoma-Coptidis Rhizoma-Curcumae Longae Rhizoma, DH-HL-JH) primarily act on the core targets (AKT1, SRC, and JUN) via the core components (rhein, quercetin, stigmasterol, and curcumin), regulate the signal pathway (PI3K-Akt, MAPK, EGFR, and VEGF signaling pathways), and play a role of anti-LF.…”

Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes by Seok Joon Shin (555061)

“…The aim of this study was to investigate the effects of a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, dapagliflozin, on renal RAS in an animal model with type 2 diabetes.…”

ROCK inhibition with Y-27632 attenuates prion disease in mice. by Aurélie Alleaume-Butaux (446780)

“…Note that mouse infection with 22L strain is associated with decreased PrP α-cleavage at the expense of PrP β-cleavage that generates C2 fragment [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005073#ppat.1005073.ref068" target="_blank">68</a>, <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005073#ppat.1005073.ref069" target="_blank">69</a>]. n = 5 for each condition. …”

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma by Patricia C. Sanchez-Diaz (403746)

“…UCHL1 depletion in SF188 and SJ-GBM2 glioma cells was associated with decreased cell proliferation and invasion, along with a reduced ability to grow in soft agar and to form spheres (i.e. self-renewal measure). …”

Activity and Reactivity of Fe²⁺ Cations in the Zeolite. Ab Initio Free-Energy MD Calculation of the N₂O Dissociation over Iron-Exchanged Ferrierite by Lubomir Benco (1987384)

“…The reactivity of cations is inspected via the temperature-dependent molecular dynamics (MD) simulation. …”

Table_4_Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Ab... by Meilan Liu (739272)

“…Background<p>Unexplained recurrent spontaneous abortion (URSA) is a common pregnancy complication and the etiology is unknown. …”

Flow diagram. by Katja Linde (4169875)

“…This is the first study that investigates prevalence rates of body image dissatisfaction not only ante- but also postpartum, and that compares trajectories of women with normal weight and overweight.</p><p>Methods</p><p>A prospective longitudinal design with a quantitative approach was applied. …”

DataSheet_1_Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneou... by Meilan Liu (739272)

“…Background<p>Unexplained recurrent spontaneous abortion (URSA) is a common pregnancy complication and the etiology is unknown. …”

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3 by Zheng-Zhao Liu (9599127)

“…<p>Senile osteoporosis (OP) is often concomitant with decreased autophagic activity. OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. …”

Exogenous expression of variants of the small G protein, N-Ras, inhibits HIV-1 gene expression. by Raymond W. Wong (8463498)

“…Although 5342191 also stimulates JNK and MK-2 (a target of p38 MAPK), it achieves suppression of HIV-1 gene expression without initiating p38 MAPK or NCX-mediated [Ca²⁺]_i flux observed with CSs (<b>E</b>, detailed in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1008307#ppat.1008307.s021" target="_blank">S15 Fig</a>). 5342191 treatment of cells decreases accumulation of HIV-1 incompletely-spliced (US/SS) RNAs (and increases MS RNAs, progressively-red arrow; <b>F</b>) through activation of GPCR and MEK1/2-ERK1/2 signals described in (<b>E</b>) and impedes buildup of essential viral regulatory proteins (Tat and Rev, <b>F</b>). …”

Raw measurement data. by Shenglong Xue (19369976)

“…Taking NSAIDs in a high-altitude hypoxic environment can exacerbate GIT injury and impact gut microbiota. …”

ELISA data. by Shenglong Xue (19369976)

“…Taking NSAIDs in a high-altitude hypoxic environment can exacerbate GIT injury and impact gut microbiota. …”

Promotion of Iridium-Catalyzed Methanol Carbonylation:  Mechanistic Studies of the Cativa Process by Anthony Haynes (2015338)

“…Ab initio calculations support a more facile methyl migration in <b>4</b>, the principal factor being decreased π-back-donation to the carbonyl ligands compared to <b>2</b>. …”

Promotion of Iridium-Catalyzed Methanol Carbonylation:  Mechanistic Studies of the Cativa Process by Anthony Haynes (2015338)

“…Ab initio calculations support a more facile methyl migration in <b>4</b>, the principal factor being decreased π-back-donation to the carbonyl ligands compared to <b>2</b>. …”

Graphical overview of study. by Brian Foo (19273132)

“…<p>A) Overview of SEC-MS based complexome profiling workflow to identify changes in high-MW protein complexes in R14Δ-PLN mouse hearts. …”

Starvation increases arousal threshold. by Elizabeth B. Brown (4582978)

“…<p>(A) Total sleep and arousal threshold were assessed for 24 hrs on standard food (Control) and then starved for 24 hrs on agar (Sleep Dep). …”

Synthesis and Comparative η¹-Alkyl and Sterically Induced Reduction Reactivity of (C₅Me₅)₃Ln Complexes of La, Ce, Pr, Nd, and Sm by William J. Evans (529233)

“…The synthesis of (C₅Me₅)₃Ce and (C₅Me₅)₃Pr from [(C₅Me₅)₂Ln][(μ-Ph)₂BPh₂] and KC₅Me₅ completes the series of sterically crowded (C₅Me₅)₃Ln complexes for the larger lanthanides, La−Nd and Sm, and allows a comparison of structure and reactivity as a function of metal size. …”