Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Compared with control animals, CCl₄-treated rats demonstrated obvious liver injury and fibrosis, manifested as increases in gray values, distal diameter of portal vein (DDPV) and a decrease in blood flow velocity (VPV) in the ultrasound analysis; increased biochemical index values (serum levels of ALT, AST, TBIL, and ALP); marked increases in the contents of fibrotic markers (PC III, COL4, LN, HA) and inflammatory factors (serum TNF-α, IL-6, and IL-1β); and significant pathological changes. …”

UBR3 affects Shh signaling in mammalian cells by poly-ubiquitinating Kif7. by Tongchao Li (115391)

DataSheet_2_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Currently, DHA production costs are high due to fermentation inefficiency; however, improving DHA yield by metabolic engineering in thraustochytrids is one approach to reduce these costs. In this study, a high-yielding (53.97% of total fatty acids) DHA production strain was constructed by disrupting polyunsaturated fatty acid beta-oxidation via knockout of the 2,4-dienyl-CoA reductase (DECR) gene (KO strain) in Aurantiochytrium sp. …”

DataSheet_1_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Currently, DHA production costs are high due to fermentation inefficiency; however, improving DHA yield by metabolic engineering in thraustochytrids is one approach to reduce these costs. In this study, a high-yielding (53.97% of total fatty acids) DHA production strain was constructed by disrupting polyunsaturated fatty acid beta-oxidation via knockout of the 2,4-dienyl-CoA reductase (DECR) gene (KO strain) in Aurantiochytrium sp. …”

DataSheet_1_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Currently, DHA production costs are high due to fermentation inefficiency; however, improving DHA yield by metabolic engineering in thraustochytrids is one approach to reduce these costs. In this study, a high-yielding (53.97% of total fatty acids) DHA production strain was constructed by disrupting polyunsaturated fatty acid beta-oxidation via knockout of the 2,4-dienyl-CoA reductase (DECR) gene (KO strain) in Aurantiochytrium sp. …”

DataSheet_2_Metabolic Engineering to Improve Docosahexaenoic Acid Production in Marine Protist Aurantiochytrium sp. by Disrupting 2,4-Dienoyl-CoA Reductase.docx by Shitong Liang (13049235)

“…Currently, DHA production costs are high due to fermentation inefficiency; however, improving DHA yield by metabolic engineering in thraustochytrids is one approach to reduce these costs. In this study, a high-yielding (53.97% of total fatty acids) DHA production strain was constructed by disrupting polyunsaturated fatty acid beta-oxidation via knockout of the 2,4-dienyl-CoA reductase (DECR) gene (KO strain) in Aurantiochytrium sp. …”

Generative model-based decomposition of pupil-size measurements and example correction result. by Kyung Yoo (11851776)

The model of this work. by Huang Tang (2997894)

Air-Stable Spin-Coated Naphthalocyanine Transistors for Enhanced Chemical Vapor Detection by James E. Royer (1904821)

“…The observed mobility decreases for both sensors are consistent with electron donation trends via hydrogen bonding by basic analytes. …”

BPR is predicted to bias pupil size because blink rate and pattern vary across time, working-memory load, and subjects. by Kyung Yoo (11851776)

Adaptive scaling of contributions from force-field and cryo-EM density data overcomes potential energy barriers without excessive work input. by Christian Blau (4665502)

Complement evasion factor (CEF), a novel immune evasion factor of <i>Streptococcus pyogenes</i> by Haniyeh Aghababa (12020666)

“…This is the first example of a <i>S. pyogenes</i> virulence factor binding to several different target proteins via glycan-dependent interactions.…”

Table_1_Specific Inhibition of CYP4A Alleviates Myocardial Oxidative Stress and Apoptosis Induced by Advanced Glycation End-Products.docx by Rui Wang (52434)

“…The present work aimed to investigate whether CYP4A mediates AGEs-induced myocardial injury. AGEs solution was administered intragastrically to C57BL/6 mice for 60 days, while the specific inhibitor of CYP4A, HET0016, was given from the 47th day via intraperitoneal injection for 2 weeks. …”

The effects of CHRM2 knockdown on osteogenic differentiation and cell proliferation. by Cheng Zhong (573294)

A Protease Inhibitor as a Potential Therapy for Inherited Retinal Degeneration by Pratik Shah (281059)

“…The data for the Nelfinavir treated group has a high standard deviation, a larger sample size may give a more accurate representation of the effect the drug has on rd1 retina. …”

Effect of DM, and/or <i>M. charantia</i> on the immuno-expressional level of GFAP protein in maternal cerebellar tissue of different groups. by Amoura M. Abou-El-Naga (21001524)

Neutrophil Superoxide anion production, Heat map for gene expression from neutrophils of CGD patients, and PCA plot for genome-wide gene expression. by Daniel R. Ambruso (12042605)

“…<p><b>3A. Superoxide anion production</b> was measured as SOD inhibitable cytochrome c reduction in response to PMA and fMLF as noted. …”

The results of the brain age monotonicity analysis for interval 3. by Siamak K. Sorooshyari (9014891)

The effect of instilling the ophthalmic solution on the LF/HF ratio and typical cases of fluctuations in the LF/HF ratio over time in the DE and non-DE groups. by Minako Kaido (309626)

“…The fluctuation in the LF/HF ratio of the DE case is larger than of the non-DE case, and it decreases post-instillation. …”

data_sheet_1_High-Frequency Repetitive Magnetic Stimulation Enhances the Expression of Brain-Derived Neurotrophic Factor Through Activation of Ca2+–Calmodulin-Dependent Protein Kin... by Ahreum Baek (5179652)

“…Therefore, in this study, we examined the global gene expression patterns depending on different frequencies of repetitive magnetic stimulation (rMS) in both undifferentiated and differentiated Neuro-2a cells to generate a comprehensive view of the biological mechanisms. …”