Supplementary Material for: Management and Survival of Pleural Mesothelioma: A Record Linkage Study by Carioli G. (4838469)

“…<b><i>Objectives:</i></b> To assess management, overall survival (OS), and their predictors in a cohort of patients from Lombardy, the largest Italian region (about 10 million inhabitants). …”

Polyamine depletion reroutes energy production to glycolysis. by Yazmin E. Cruz-Pulido (20285238)

<em>Gemini</em>, a Bifunctional Enzymatic and Fluorescent Reporter of Gene Expression by Lance Martin (257830)

“…We show that the protein fusion increases the sensitivity of β-gal activity and decreases the sensitivity of GFP.</p><h3>Conclusions/Significance</h3><p><em>Gemini</em> is therefore a bifunctional reporter with a wider dynamic range than the β-gal α-fragment or GFP alone. …”

OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB Function by Tanusree Sen (119721)

“…Forced expression of OGDHL increased the production of reactive oxygen species (ROS) leading to apoptosis through caspase 3 mediated down-regulation of the AKT signaling cascade and decreased NF-κB phosphorylation. Conversely, silencing OGDHL stimulated the signaling pathway via increased AKT phosphorylation. …”

(a) Ranking order of DNA/DNA mismatch binding affinities (extracted from Fig by Thomas Naiser (50406)

“…Purine-purine MMs (purine bases highlighted in blue) display the largest decrease of binding afinities with respect to other MM-types.…”

A comparable scheme of AFC under normal vs. Ang II stimulated conditions. by Reem Ismael-Badarneh (3213921)

“…<p>Under normal conditions Na+ is extruded out of the alveolar airspace by apical epithelial Na+ channels (ENaC), specifically highly selective cation channels composed of α, β and γ subunits (HSC) and basolateral Na,K-ATPase pump with water following osmoticaly, Whereas Ang II stimulation down regulated cAMP levels in AEC II, via AT1 receptors triggering, thus leading to the decrease of the two important AFC players; αNa,K-ATPase and the HSC, and an increase of the NSC (non-selective cation channels composed of α subunit alone), with a resultant impairment of sodium reabsorption and conceivable AFC decrease.…”

Is thermal stability a factor that influences environmental heterogeneity and phytoplankton distribution in tropical lakes? by Luciana Gomes Barbosa (5139065)

“…In the epilimnion, the dominance of small chlorophytes and desmids (NA, A and X1, ≤20μm) and larger dinophyceans (Lo, ≥20μm) were associated with high turbulence and light availability and soluble phosphorus limitation. …”

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study by Irene Pichler (76506)

“…</p><p>Conclusions</p><p>Our study suggests that increased iron levels are causally associated with a decreased risk of developing PD. Further studies are needed to understand the pathophysiological mechanism of action of serum iron on PD risk before recommendations can be made.…”

A global meta-analysis of the effects of plant diversity on biomass partitioning in grasslands by Chao Wang (8847089)

“…In this study, we explored the global patterns and associated drivers of biomass partitioning responding to plant diversity by conducting a meta-analysis of 333 observations from 30 studies in grasslands worldwide. …”

Thermorheological characteristics and extrudability aptitude of a new amylose-free cassava starch by Adriana Pulido Diaz (10448430)

“…There were significant differences in the pasting profiles evaluated, with WXCS being thermally less stable (Breakdown = 698±2 cP) generating less viscous final pastes (731±16 cP) compared to a commercial amylose-free corn starch. The WXCS shear viscosity was determined in a capillary rheometer (Rheoplast®), showing an inverse linear temperature dependence, decreasing by a factor larger than 3 when the temperature changed from 100 to 120 °C, with a pseudoplastic flow described by the power law (n: 0.25-0.40), consistency index (32607 - 6695 Pa.s) and specific mechanical energy (124 - 75 J/g). …”

A mechanism that changes the persistency of NF-κB_n oscillation. by Daisuke Ohshima (129662)

“…Reduced <i>k</i>_<i>3</i> resulted in ΔmRNA_IκB levels greater than control at a much earlier time point (panel c). The level of ΔmRNA_IκB.n was larger in decreased <i>k</i>_<i>3</i> from the start of oscillation and displayed a steep increase (green arrow in panel d). …”

Effect of fenretinide on endometrial tumor progression in an Ishikawa xenograft mouse model (A–C). by Navdha Mittal (650261)

“…The largest decrease in tumor size was observed in the mice treated with fenretinide alone.…”

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer by Kelly Coffey (129302)

“…Cellular activity was confirmed by analysis of acetylation of histone and non-histone proteins in a prostate cancer cell line model. NU9056 treatment inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8–27 µM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. …”

Exploration of Sweeping Effect: Droplet Coalescence Jumping of a Rolling and Static Droplet by Chuntian Liu (4264399)

“…In this work, we experimentally and numerically study the coalescence of a rolling droplet and a static one. When the droplet radius ratio is larger than 0.8, as the dimensionless initial velocity increases and the vertical jumping velocity first decreases and then increases. …”

Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis by Maria Camprubi Robles (826043)

“…Therefore, more trials that include larger populations are warranted to elucidate whether gestational diabetes mellitus (GDM) has a negative impact on offspring central nervous system (CNS).…”

A Systematic Review of Studies Comparing Diagnostic Clinical Prediction Rules with Clinical Judgment by Sharon Sanders (748932)

“…In 2 comparisons (4%), CPRs reduced the proportion of missed diagnoses, but this was offset by classifying a larger proportion of study participants as having disease (more false positives). …”

Table1_Cariprazine augmentation of clozapine in schizophrenia—a retrospective chart review.DOCX by Marcin Siwek (9967193)

“…One patient discontinued the treatment due to side effects (akathisia), and two patients halted the therapy due to the exacerbation of psychotic symptoms. Our study presents a thorough clinical description of the largest number of treatment-resistant schizophrenia patients medicated using cariprazine augmentation of clozapine in a “real-world” setting. …”

Reported Radiation Overexposure Accidents Worldwide, 1980-2013: A Systematic Review by Karen Coeytaux (705595)

“…Although underreporting can be an issue, some extensive literature reviews of reported radiation overexposures have been performed and constitute a sound basis for conclusions on general trends. …”

SMO inhibits PKA substrate phosphorylation in a G protein–independent manner. by Corvin D. Arveseth (10688311)

“…Alternatively, SMO may inhibit PKA-C via a G protein–independent mechanism (route “2”). …”

Bicarbonate concentration and pH value in the PF in a canine AP model. by Yuepeng Jin (635725)

“…<p>AP was induced by a retrograde injection of 5% sodium taurocholate (0.5 ml/kg) via the main pancreatic duct. …”