Sinking towards destiny: High throughput measurement of phytoplankton sinking rates through time-resolved fluorescence plate spectroscopy by Catherine C. Bannon (4487728)

“…We verified the method through experimental analysis of known factors that influence sinking rates, including exponential versus stationary growth phase in species of different cell sizes; <i>Thalassiosira pseudonana</i> CCMP1335, chain-forming <i>Skeletonema marinoi</i> RO5A and <i>Coscinodiscus radiatus</i> CCMP312. We fit decay curves to an algebraic transform of the decrease in fluorescence signal as cells sank away from the fluorometer detector, and then used minimal mechanistic assumptions to extract a sinking rate (m d^-1) using an RStudio script, SinkWORX. …”

A Humanized Mouse Model of HPV-Associated Pathology Driven by E7 Expression by Águeda Buitrago-Pérez (149456)

“…Finally, our findings indicate a decrease of the <em>in vitro</em> capacity of HPV5 E7 to reduce pRb levels <em>in vivo</em>, possibly explaining the phenotypical differences when compared with 16E7-grafts. …”

A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells by Cristina Martin-Granados (151101)

“…In addition, we identify PP1/NIPP1 as a novel molecular compass that controls directed cell migration via upregulation of Cdc42 signalling and suggest a way by which PP1/NIPP1 may contribute to the migratory properties of cancer cells.…”

Supplementary Material for: Protective effects of Xanthohumol against diabetic nephropathy in a mouse model by Li F. (3206265)

“…Discussion/Conclusion: Xanthohumol could ameliorate DN-related impairments via Nrf2 signaling pathway, which might serve as a promising drug candidate for treatment of DN.…”

Data_Sheet_1_A Novel Role for the Periaqueductal Gray in Consummatory Behavior.PDF by Valerie Lee Tryon (5689283)

“…To address this, PAG was pharmacologically inactivated during a spatial working memory task with muscimol (0.1–0.3 μg), a GABA_A agonist via intracranial infusion. …”

Design and Synthesis of EZH2-Based PROTACs to Degrade the PRC2 Complex for Targeting the Noncatalytic Activity of EZH2 by Zhihao Liu (419349)

“…EZH2 mediates both PRC2-dependent gene silencing via catalyzing H3K27me3 and PRC2-independent transcriptional activation in various cancers. …”

(a)–(d) depict the time derivation of the average investing strategies for different time-horizons. by Jan Jurczyk (3162819)

“…<p>In (a) with <i>ω</i> = 1 year the three major crisis in the time from 2003 until 2016 exhibit the three largest drops. …”

Data Sheet 1_Feasibility and acceptability of a single-session perioperative acceptance and commitment therapy workshop for preventing chronic postsurgical pain: a single-arm, non-... by Jolin B. Yamin (8544489)

“…Exploratory analyses examining health outcome changes following ACT during the post-surgery period revealed that pain severity and interference, depression and anxiety all decreased over time.</p>Discussion<p>These findings suggest that a single-session ACT intervention is feasible and acceptable for patients undergoing SS and may enhance both pain-related functioning and improve psychological outcomes following surgery. …”

The interaction between tonic GABA_AR signaling and glutamatergic activity. by Michelle Day (11617621)

“…In the absence of NMDARs, a combination of onsite shunt and reduced AMPAR driving force arising from depolarization presumably underlies the GABA conductance density-dependent decrease in response. …”

Data_Sheet_1_Antiepileptic Effects of a Novel Non-invasive Neuromodulation Treatment in a Subject With Early-Onset Epileptic Encephalopathy: Case Report With 20 Sessions of HD-tDCS... by Oded Meiron (6746969)

“…Myoclonic seizure (M-S) frequency was significantly reduced [t(4) = 3.83, p = 0.019] by 68.42%, compared to baseline, and indicated a significant clinical change as well. A 73% decrease in interictal epileptic discharges (IEDs) frequency was also observed immediately after the intervention period, compared to IED frequency at 3 days prior to intervention. …”

Data_Sheet_1_A Computational Model for the Cold Response Pathway in Plants.pdf by Ruqiang Zhang (9603896)

“…Sometimes, instead of a single Ca²⁺ spike the decrease in temperature brings about a train of high-frequency Ca²⁺ oscillations. …”

Restoration of bladder neck activity and levator hiatus dimensions in Asian primipara: a prospective study by Zexuan Yang (14585926)

“…We found that bladder neck descent (BND) increased significantly from 2 weeks onwards until 6 weeks postpartum; the levator hiatus area at rest and contraction both showed the largest value at 2 weeks postpartum, followed by a continuous decrease; the hiatus area during Valsalva manoeuvre, and the levator hiatus distensibility and contractility showed the lowest value at 2 weeks postpartum, followed by a continuous increase; the changes in BND showed no correlation with the changes in distensibility or hiatus area during Valsalva manoeuvre.…”

Behavioral results from young adults in the three emotional cognitive tasks. by Sang-Eon Park (2178200)

Biological characteristics of a conditional c-Myc mouse liver tumor cell line. by Kyu Yun Jang (134932)

“…E) Morphologically, MYC-OFF cells are larger than MYC-ON cells and have larger nuclei, increased cytoplasm, inconspicuous nucleoli, decreased nuclear-cytoplasmic ratio and more cytoplasmic processes. …”

Number of retinue workers attending queens at different seasonal time points. by Mark J. Carroll (3605582)

An Essential Nuclear Protein in Trypanosomes Is a Component of mRNA Transcription/Export Pathway by Mariana Serpeloni (218260)

“…<div><p>In eukaryotic cells, different RNA species are exported from the nucleus via specialized pathways. The mRNA export machinery is highly integrated with mRNA processing, and includes a different set of nuclear transport adaptors as well as other mRNA binding proteins, RNA helicases, and NPC-associated proteins. …”

Temperature-Induced Phase Transitions of Vivianite: In Situ Analysis of a Redox-Driven Crystallization by Alice Paskin (10017280)

“…Rietveld refinements of the two crystalline endmembers (vivianite and graftonite) revealed a unit cell volume decrease of ∼3.1% during the transformation, which was observed by in situ electron microscopic observations as an overall shrinking of the initial vivianite crystals. …”

Flame Propagation and Combustion Phenomena in a Confined Space with the Perforated Plate at Different Positions by Lei Zhou (19808)

“…Subsequently, a large hole size results in a turbulent eddy with a larger eddy structure, and consequently the turbulent flame acceleration behavior becomes more obvious for the hole size of 5 mm. …”

An idealized view of the opportunity provided by a comparative and integrated oncology drug development path. by Ira Gordon (369869)

“…Data for transition rates and costs of Phase I, II, and III trials are based on published cost estimates <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000161#pmed.1000161-DiMasi2" target="_blank">[3]</a> and reported clinical phase transition probabilities for investigational oncology compounds from the 20 largest firms (by pharmaceutical sales in 2005) from 1993 to 2002 <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000161#pmed.1000161-DiMasi1" target="_blank">[2]</a>,<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000161#pmed.1000161-Roberts1" target="_blank">[4]</a>. …”

Histograms of clonal sizes for the individual simulation with parameters as described in Fig 8. by John M. Murray (150672)