Image_2_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Image_2_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt by Frank A. Suprynowicz (4237495)

“…Here we show that β-catenin-dependent transcription is necessary for the induction of epithelial stem cell markers, and that β-catenin is activated via a non-canonical pathway that is independent of Wnt and Akt/GSK-3. …”

<i>Tripneustes gratilla</i> larvae reared for 5 days in 3 pH and 2 temperature treatments. by Hannah Sheppard Brennand (363698)

“…With increased acidity/<i>P</i>_CO2 larval size decreased and there was an increase in abnormal development.…”

Analysing mHealth usage logs in RCTs: Explaining participants’ interactions with type 2 diabetes self-management tools by Meghan Bradway (5703473)

“…We use the logs collected by persons with type 2 diabetes during a randomized controlled trial (RCT) as a use-case.…”

Image_1_Reduction of HIV-1 Reservoir Size and Diversity After 1 Year of cART Among Brazilian Individuals Starting Treatment During Early Stages of Acute Infection.tif by Thaysse Ferreira Leite (6320159)

“…Compared to PRE_ART, M12_ART saw an immunological recovery with a gain of ∼200 CD4⁺ T cells (P = 0.008) and a normalization of the CD4/CD8 ratio [1.0 (IQR: 0.88–1.18), P = 0.016], as well as a significant decrease in HIV-1 RNA (∼4 log, P = 0.004) and DNA (∼1 log, P = 0.002) levels. …”

Characterization of the Bis(azido)(<i>meso</i>-tetraphenylporphinato)ferrate(III) Anion. An Unusual Spin-Equilibrium System by Mary K. Ellison (2117293)

“…A fit of the powder EPR spectrum at 4.2 K with a crystal field model that allows quartet and sextet admixtures suggests that the first sextet state is ∼655 cm^-1 above the ground doublet. Single-crystal EPR data indicate that the largest <i>g</i> value occurs at an angle of 56° from the porphyrin normal and at 35 and 81° from the Fe−N_p vectors. …”

Knock-down of IGFN1 isoforms by shRNAs does not prevent expression of differentiation markers. by Xiang Li (114679)

“…Note depletion of the largest IGFN1 protein variants. B) Two knock down clones, obtained with sh-2-IGFN1 targeting a different sequence of IGFN1 3’ UTR, showing decreased complexity of IGFN1 products compared to the C2C12 cell line, as labelled.…”

Average internal state of the colony for various colony sizes (<i>N</i> = 20–200 at increments of 20 workers). by Simeon Adejumo (14838827)

“…At smaller colony sizes (<i>N</i> = 20, 40, and 60), the average internal state of workers decreases as a function of time and stabilises at a point which is lower than the initial value. …”

table_2_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…To understand the diverse effects of AIRE, it is crucial to elucidate the molecular mechanisms underlying the process of AIRE-regulated gene expression. In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

image_2_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…To understand the diverse effects of AIRE, it is crucial to elucidate the molecular mechanisms underlying the process of AIRE-regulated gene expression. In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

table_1_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…To understand the diverse effects of AIRE, it is crucial to elucidate the molecular mechanisms underlying the process of AIRE-regulated gene expression. In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

table_3_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…To understand the diverse effects of AIRE, it is crucial to elucidate the molecular mechanisms underlying the process of AIRE-regulated gene expression. In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

image_1_Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating ST... by Thomas R. J. Lovewell (739674)

“…To understand the diverse effects of AIRE, it is crucial to elucidate the molecular mechanisms underlying the process of AIRE-regulated gene expression. In this study, we generated a recombinant AIRE expression variant of the TEC 1A3 human cell line, TEC 1A3 AIRE^hi, to determine genes targeted by AIRE, and using microarray analysis, we identified 482 genes showing significant differential expression (P < 0.05; false discovery rate <5%), with 353 upregulated and 129 downregulated by AIRE expression. …”

Systemic administration of rAAV6-μDys enhances the structural properties of EDL muscles in dystrophic mice. by Joshua Park (719780)

Data_Sheet_1_A System Integration Analysis of a Molten Carbonate Electrolysis Cell as an Off-Gas Recovery System in a Steam-Reforming Process of an Oil Refinery.docx by Andrea Monforti Ferrario (10679244)

“…The results have shown that it is possible to obtain an electrochemical Specific Energy Consumption for the production of H₂ of 3.24 kWh/NmH23 using the MCEC, whereby the possible integration of a 1-MW_e module with a reformer of the proposed plant not only increases the hydrogen yield but also decreases the amount of fuel needed to assist the reforming reaction and separates a CO₂ stream after additional purification via an oxy-fuel combustor, consequently determining lower greenhouse gases emissions.…”

Systemic colonization of potato plants resulting from potato haulm inoculation with <i>Dickeya solani</i> or <i>Pectobacterium parmentieri</i> by P. Kastelein (9287217)

“…In a glasshouse experiment, populations of the pathogens increased in haulms in the first week after chemical or mechanical destruction, but decreased in the second week. …”

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala by Brendan J. Tunstall (6593357)

“…<div><p>Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-seeking associated with several drugs of abuse and thus represents a promising pharmacological approach to treat drug addiction. …”

Table_2_Rest-Phase Hypothermia Reveals a Link Between Aging and Oxidative Stress: A Novel Hypothesis.XLSX by Elisavet Zagkle (9747269)

“…We found age-related differences in night-time body temperature following a day-long food deprivation while all three age groups remained normothermic in the night following a day with access to food. …”

Table_1_Rest-Phase Hypothermia Reveals a Link Between Aging and Oxidative Stress: A Novel Hypothesis.docx by Elisavet Zagkle (9747269)

“…We found age-related differences in night-time body temperature following a day-long food deprivation while all three age groups remained normothermic in the night following a day with access to food. …”