An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition حسب Angus J. Robertson (11535072)

"…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …"

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition حسب Angus J. Robertson (11535072)

"…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …"

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition حسب Angus J. Robertson (11535072)

"…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …"

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition حسب Angus J. Robertson (11535072)

"…Here, we use β-phosphoglucomutase (βPGM) to investigate the relationship between binding a phosphodianion group in a distal site, the adoption of a closed enzyme form, and catalytic proficiency. βPGM catalyzes the isomerization of β-glucose 1-phosphate to glucose 6-phosphate via phosphoryl transfer reactions in the proximal site, while coordinating a phosphodianion group of the substrate(s) in a distal site. βPGM has one of the largest catalytic proficiencies measured and undergoes significant domain closure during its catalytic cycle. …"

Fig 1 - حسب Seraphine Zeitouny (16954499)

Fig 2 - حسب Seraphine Zeitouny (16954499)

Prevalence^a of obesity^b among public school youth in grades K-8 by school year and selected characteristics, New York City, 2011–12 to 2019–20. حسب Kira L. Argenio (18563302)

Prevalence^a of severe obesity^b among public school youth in grades K-8 by school year and selected characteristics, New York City, 2011–12 to 2019–20. حسب Kira L. Argenio (18563302)

Predictions from the <i>allometric heat-dissipation model</i> for realised travel speed as a function of body mass with the allometric scaling exponent <i>c</i> fitted independentl... حسب Alexander Dyer (15314519)

Histograms of (A) distance measured in meters to nearest neighboring tree given bin widths of 2 m (<i>n</i> = 44), and (B) basal areas of all sampled trees (<i>n</i> = 58; bin widt... حسب Alexandra M. Campbell (3284094)

The distribution of water footprint levels in China. a, 2005. b, 2010. c, 2015. d, 2022. حسب Jianqin Ma (20328414)

Cesarean section rates from January 2017 to December 2019 (pre-policy period: January-December 2017; post-policy period: January 2018-December 2019). حسب Ingvild Hersoug Nedberg (11384048)

Perinatal outcomes from January 2017 to December 2019 (pre-policy period: January-December 2017; post-policy period: January 2018-December 2019). حسب Ingvild Hersoug Nedberg (11384048)

Model showing the intergenerational inheritance of starvation memory from the mothers to the progeny via the RpL10Ab negative feedback loop. حسب Kelly Voo (11767979)

Distribution of <i>L</i>(<i>p</i>) with an absolute error when a single observation is randomly sampled at each time point, with the smallest observation (blue) and the largest obs... حسب Hyeontae Jo (20469463)

Predictions from the constant heat-dissipation model for realised travel speed as a function of body mass with the heat-dissipation time constant <i>k</i>₀ fitted indepe... حسب Alexander Dyer (15314519)

AMPs are increased in lesional HS, but DCD and other sweat-gland associated proteins are decreased. حسب Margaret Coates (6058580)

"…<p>(A) Volcano plot showing increased or decreased genes in HS. …"

Innovation and night light in large and small cities. حسب Saul Estrin (8629173)

Summary statistics of key variables. حسب Saul Estrin (8629173)

"…We find that in developing countries, as urban economic density increases, innovation first increases and then begins to decrease beyond a certain point, with the decline being most prominent in the largest cities. …"

Nightlight densities in the lowest, around the median and the highest ranked cities in the sample and the distribution of firms in each city. حسب Saul Estrin (8629173)