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larger decrease » marked decrease (Expand Search)
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10861
Image_2_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom...
Published 2018“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C<sub>max</sub>, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC<sub>0-Inf</sub>, 222.1 ng/mL h), markedly decreased distribution volume (V<sub>z</sub>, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C<sub>max</sub> (26.6 ng/mL) and AUC<sub>0-Inf</sub> (95.1 ng/mL h), larger V<sub>z</sub> (688.8 L) and CL (22.1 L/h) for VSI. …”
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10862
Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom...
Published 2018“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C<sub>max</sub>, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC<sub>0-Inf</sub>, 222.1 ng/mL h), markedly decreased distribution volume (V<sub>z</sub>, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C<sub>max</sub> (26.6 ng/mL) and AUC<sub>0-Inf</sub> (95.1 ng/mL h), larger V<sub>z</sub> (688.8 L) and CL (22.1 L/h) for VSI. …”
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10863
Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
Published 2017“…However, further research is needed with larger numbers of animals for a more robust statistical power to fully characterize the early and late effects of simulated microgravity combined with exposure to low-dose rate ionizing radiation on the heart.…”
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10864
Equilibrium model predictions for the pattern formation time and readout error.
Published 2018“…<p>(A) The early nuclear cycles have a short interphase <i>T</i><sub>full</sub> and even shorter steady state periods <i>T</i> when the average transcription rate is neither increasing after, nor decreasing before, transcription shut-off during mitosis. …”
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10865
Data_Sheet_1_PET image enhancement using artificial intelligence for better characterization of epilepsy lesions.docx
Published 2022“…We trained a ResNet on 80% of this dataset (10% used for validation) to learn the mapping between S-SQ and GT-HQ PET, outputting a predicted HQ (P-HQ) PET. …”
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10866
Table_2_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.DOCX
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10867
Image_4_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10868
Image_7_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10869
Table_3_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.DOCX
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10870
Image_1_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10871
Image_5_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10872
Table_1_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.DOCX
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10873
Table_4_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.DOCX
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10874
Image_6_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10875
Image_2_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10876
Image_8_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10877
Image_3_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10878
Image_9_Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas.jpg
Published 2019“…</p><p>Objective: To establish the replicative frequency and transcriptional identity of CPHN cells, extending our observation on CPHN cell frequency to a larger cohort of fetal and infant pancreas.</p><p>Design, Setting, and Participants: 8 fetal, 19 infant autopsy pancreata were evaluated for CPHN cell frequency; 12 fetal, 24 infant/child pancreata were evaluated for CPHN replication and identity.…”
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10879
Influence of the bulk viscosity on the convergence and extension of GB.
Published 2017“…While the posterior-wards flow at the GB posterior end is similar, the lateral flow is strongly affected with a much larger ventral-wards convergent flow along DV when the bulk viscosity is reduced to 10 (whereas no qualitative change is seen between 10<sup>3</sup> and 10<sup>2</sup>). …”
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10880
Image_1_Natural Vascular Scaffolding Treatment Promotes Outward Remodeling During Arteriovenous Fistula Development in Rats.tiff
Published 2021“…Natural Vascular Scaffolding (NVS) Therapy is a new technology that interlinks collagen and elastin via photoactivation of a locally delivered small molecule (4-amino-1,8-naphtalamide). …”