<i>LSM12</i> posttranscriptionally up-regulates <i>EPAC1</i> expression to sustain the RAN gradient for NCT. by Jongbo Lee (9914603)

“…(D) LSM12 depletion posttranscriptionally decreases <i>EPAC1</i> expression via the 5′ UTR. <i>EPAC1</i> reporter plasmids encoding NLUC were generated as depicted in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001002#pbio.3001002.s007" target="_blank">S7B Fig</a>. …”

Emulsion Solvent Evaporation-Induced Self-Assembly of Block Copolymers Containing pH-Sensitive Block by Yuqing Wu (628490)

“…Furthermore, homopolymer with different molecular weights and addition ratio are employed to adjust the interactions among copolymer blocks. By this means, particles with hierarchical structures can be obtained. …”

(A) Longitudinal sections of soleus immunostained using antiserum 46 to plectin by Patryk Konieczny (47697)

“…Data, relative to WT samples (100%), represent the means ± SEM of three experiments.<p><b>Copyright information:</b></p><p>Taken from "Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms"</p><p></p><p>The Journal of Cell Biology 2008;181(4):667-681.…”

Image 1_Caffeine on the mind: EEG and cardiovascular signatures of cortical arousal revealed by wearable sensors and machine learning—a pilot study on a male group.jpeg by Shabbir Chowdhury (22246345)

“…EEG was recorded from seven central electrodes (C3, Cz, C4, CP1, CP2, CP5, CP6) using the EMOTIV EPOC Flex system, and heart rate (HR) and blood pressure (BP) were continuously monitored via the Huawei Watch D. Data analysis included power spectral density (PSD) estimation, FOOOF decomposition, and unsupervised k-means clustering.…”

Image_3_CD300b regulates intestinal inflammation and promotes repair in colitis.jpeg by Shmuel Avlas (14825695)

“…Subsequently, current therapeutic approaches target immune-mediated pathways as means for therapeutic intervention and promotion of mucosal healing and repair. …”

Image_1_CD300b regulates intestinal inflammation and promotes repair in colitis.jpeg by Shmuel Avlas (14825695)

“…Subsequently, current therapeutic approaches target immune-mediated pathways as means for therapeutic intervention and promotion of mucosal healing and repair. …”

DataSheet_3_mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.docx by Siawosh K. Eskandari (12858206)

“…Here, we assessed the role of inhibiting mechanistic target of rapamycin complex 1 (mTORC1), a recently favored drug target in the transplant field, in regulating human T_reg apoptosis via GrB. Using ex vivo models of human T_reg culture and a humanized mouse model of human skin allotransplantation, we found that by inhibiting mTORC1 using rapamycin, intracytoplasmic expression and functionality of GrB diminished in host T_regs; lowering human T_reg apoptosis by in part decreasing the phosphorylation of S6K and c-Jun. …”

Image_4_CD300b regulates intestinal inflammation and promotes repair in colitis.jpeg by Shmuel Avlas (14825695)

“…Subsequently, current therapeutic approaches target immune-mediated pathways as means for therapeutic intervention and promotion of mucosal healing and repair. …”

Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson's Leukocytes Identified by RNA Sequencing by Lilach Soreq (89966)

“…Analyzing blood cell transcripts by RNA-Seq is a robust means to identify novel biomarkers that rapidly becomes a commonplace. …”

Table_1_Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and The... by Cameron S. Metcalf (1997293)

“…<p>Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. …”

DataSheet_2_mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.docx by Siawosh K. Eskandari (12858206)

“…Here, we assessed the role of inhibiting mechanistic target of rapamycin complex 1 (mTORC1), a recently favored drug target in the transplant field, in regulating human T_reg apoptosis via GrB. Using ex vivo models of human T_reg culture and a humanized mouse model of human skin allotransplantation, we found that by inhibiting mTORC1 using rapamycin, intracytoplasmic expression and functionality of GrB diminished in host T_regs; lowering human T_reg apoptosis by in part decreasing the phosphorylation of S6K and c-Jun. …”

Image_2_CD300b regulates intestinal inflammation and promotes repair in colitis.jpeg by Shmuel Avlas (14825695)

“…Subsequently, current therapeutic approaches target immune-mediated pathways as means for therapeutic intervention and promotion of mucosal healing and repair. …”

DataSheet_1_mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.xlsx by Siawosh K. Eskandari (12858206)

“…Here, we assessed the role of inhibiting mechanistic target of rapamycin complex 1 (mTORC1), a recently favored drug target in the transplant field, in regulating human T_reg apoptosis via GrB. Using ex vivo models of human T_reg culture and a humanized mouse model of human skin allotransplantation, we found that by inhibiting mTORC1 using rapamycin, intracytoplasmic expression and functionality of GrB diminished in host T_regs; lowering human T_reg apoptosis by in part decreasing the phosphorylation of S6K and c-Jun. …”

Data_Sheet_1_Dry Season Transpiration and Soil Water Dynamics in the Central Amazon.docx by Gustavo C. Spanner (6893450)

“…Tree water use was assessed via radial patterns of sap flow in eight dominant canopy trees, each a different species with a range in diameter, height, and wood density. …”

Evidence for home advantage in the time intervals between scores. by Haroldo V. Ribeiro (277883)

“…Notice that the plots are in log-lin scale and thus the exponential decay is linearized. The values of <i>τ</i>_home and <i>τ</i>_away were estimated via maximum likelihood method and are shown in the plots. …”

Table_1_Toward a Hybrid Passive BCI for the Modulation of Sustained Attention Using EEG and fNIRS.XLSX by Alexander J. Karran (7824854)

“…The results suggest that providing a means to self-regulate sustained attention has the potential to keep operators engaged over long periods, and moderately increase on-task performance while decreasing on-task error.…”

Reversal of Obesity and Insulin Resistance by a Non-Peptidic Glucagon-Like Peptide-1 Receptor Agonist in Diet-Induced Obese Mice by Min He (44052)

“…</p><h3>Conclusions/Significance</h3><p>Boc5 may produce metabolic benefits via multiple synergistic mechanisms and may represent an attractive tool for therapeutic intervention of obesity and diabetes, by means of non-peptidic GLP-1R agonism.…”

Analysing mHealth usage logs in RCTs: Explaining participants’ interactions with type 2 diabetes self-management tools by Meghan Bradway (5703473)

“…Long-term users significantly decreased their usage over the year (<i>P</i> < .001). …”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…The RT‒PCR data are presented as the means ± SDs (n = 3). Statistical significance: ns, p ≥ 0.05. …”

Datasheet1_Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience.pdf by David Edward Youssef (14501636)

“…The suspension formulation was necessary for 103 (66.9%) patients due to an inability to take enteral tablets and for 49 (31.8%) due to a need for feeding via gastric or jejunal tubes. We observed a statistically significant increase in tricuspid annular plane systolic excursion as well as significant decreases in right-ventricular systolic pressure and NT-proBNP. …”