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marked decrease » marked increase (Expand Search)
nf decrease » _ decrease (Expand Search), a decrease (Expand Search), we decrease (Expand Search)
nn decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
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Data Sheet 1_The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway.docx
Published 2025“…</p>Discussion<p>Our findings reveal that R-2HG specifically inhibits microglial inflammatory activation by suppressing the FTO/NF-κB signaling pathway, leading to decreased IL-6 production. …”
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Polysaccharides from Black Mulberry Attenuate Colitis through Gut Microbiota Mediated TNF-α/pNF-κB/ICAM‑1 Signaling Pathway
Published 2025“…., which correlated with elevated short-chain fatty acids (SCFAs) and decreased pro-inflammatory markers. Colonic RNA sequencing revealed the role of PBM in attenuating colitis via the TNF-α/NF-κB/ICAM-1 signaling pathway. …”
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Data Sheet 1_Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.docx
Published 2025“…</p>Discussion<p>In summary, our data suggested that LD<sub>4</sub>-PDT could inhibit DSS-induced UC in rats via the NF-κB signaling pathway, indicating its potential as a novel photosensitizer for the treatment of UC.…”
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Image 1_Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis.jpeg
Published 2025“…</p>Results<p>ZQG treatment dose-dependently (1) ameliorated colonic mucosal damage, reducing histological scores by 52% compared to that in the model group, (2) modulated macrophage polarization by increasing the M2 phenotype (CD206<sup>+</sup> cells, 3.25-fold increase) while decreasing M1 macrophages (CD86<sup>+</sup> cells, 70% reduction), (3) upregulated PPAR-γ expression (2.0-fold increase) while suppressing NF-κB activation (43% decrease in p-NF-κB) and STAT1 signaling (48% and 40% reductions in protein and mRNA levels, respectively), and (4) rebalanced inflammatory cytokines, with 55%–62% reductions in TNF-α, IL-6, and IL-1β and 185%–210% increases in IL-10 and IL-4. …”
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MiR-15a-5p Knockdown up-Regulated ABCB1 Expression and Abated HNSCC Progression via the NF-κB Signaling Pathway
Published 2024“…Furthermore, the miR-15a-5p knockdown significantly suppressed HNSCC cell proliferation, migration, and invasion <i>in vitro</i>, and reduced the HNSCC tumor growth and migration capabilities <i>in vivo</i>, possibly through NF-κB signaling pathway.</p> <p>Collectively, miR-15a-5p knockdown increased the ABCB1 level and abated the HNSCC progression <i>via</i> the NF-κB signaling pathway. …”
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