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2061
Rinderine suppresses African swine fever virus replication in porcine alveolar macrophages by dual targeting of membrane-associated profilin 1 and phosphatidylethanolamine
Published 2025“…<p>African swine fever (ASF) is a highly contagious disease caused by African swine fever virus (ASFV), posing a serious threat to the global pig industry. Natural small molecules have been reported to exhibit anti-ASFV potential. …”
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2062
Data Sheet 1_The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disea...
Published 2025“…In high SDI regions, the disease burden gradually decreases after reaching its peak, while in low SDI regions, the reduction or increase in the disease burden is relatively small. …”
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2063
Data Sheet 1_Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease.pdf
Published 2025“…Specifically, we found significant decreases in insulin receptor-α (IR-α) and insulin receptor-β (IR-β) expression, along with increased levels of phospho-insulin receptor substrate 1 at Ser307 [p-IRS-1 (Ser307)] and decreased levels of p-IRS-1 (Tyr895), compared to wild-type (WT) mice. …”
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2064
Data Sheet 1_Succinic acid improves crop chemical components by regulating soil chemical properties, microbes and metabolites.docx
Published 2025“…Introduction<p>Small molecule metabolites can act as soil conditioners to improve the soil environment and thereby promote crop growth. …”
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2065
Data Sheet 1_Application of compost amended with biochar on the distribution of antibiotic resistance genes in a soil–cucumber system—from the perspective of high-dose fertilizatio...
Published 2025“…Compared with those in the control treatment group, the absolute abundance of ermB, ermT, gyrA, qnrS, tetC, and intI1 decreased by 6–100% in the soil of the SBTC group. …”
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2066
Global incidence of female birdsong is predicted by territoriality and biparental care in songbirds
Published 2025“…Daily nest predation rates decrease with body size in passerine birds. The American Naturalist, 196, 743-754. (2) life- and natural history traits from Dale et al. 2015: Dale, J., Dey, C. …”
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2067
Data from The impact of human disturbances on the regeneration layer of tropical rainforests
Published 2024“…The Hedges’ g index estimates the standardized mean difference and variance between a control and treatment sites and can be used in studies with a small sample size (Gurevitch & Hedges, 1999). In particular, negative values of Hedges’ g indicate a decrease in the response variable (e.g., richness or abundance) in disturbed sites, whereas positive values indicate the opposite. …”
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2068
Benzofuranyl-pyrazole as a Novel Scaffold for <i>In Vitro</i> and <i>In Vivo</i> Potent Anticancer Therapeutics That Directly Disrupt the ‘Undruggable’ MYC Oncogene and Potentiate...
Published 2025“…Meanwhile, it synergized with a small-molecule immune checkpoint inhibitor <i>in vivo</i>, highlighting its potential application in immunotherapy.…”
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2069
Image 4_Unraveling impact and potential mechanisms of baseline pain on efficacy of immunotherapy in lung cancer patients: a retrospective and bioinformatic analysis.jpg
Published 2024“…ELISA assay results indicated that the level of CXCL12 significantly decreased compared to baseline after pain was relieved.…”
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2070
Data Sheet 1_Biorefinery—inspired, two-step valorization strategy to manage plant-based recalcitrant organic waste, involving solvent extraction, and fermentation with Bacillus cla...
Published 2025“…This novel two-step valorization workflow involves the extraction of small molecules using organic solvents, and fermentation of resulting denatured residues (increased biodegradability or decreased recalcitrance) of reduced microbial load. …”
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2071
Table 5_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.docx
Published 2025“…</p>Conclusion<p>In the last ten years, registered pediatric drug trials have either stayed stable or slightly decreased, often featuring small sample sizes and rarely using age-specific formulations. …”
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2072
Reconciliation services product value analysis.
Published 2025“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”
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2073
Data Sheet 2_UrbanAgri: a transfer learning-based plant stress identification framework for sustainable smart urban growth.pdf
Published 2025“…<p>The speed of urbanization around the world is decreasing the arable land endangering food security since the population is estimated to reach 9.7 billion by the year 2050. …”
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2074
Table 1_Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity.docx
Published 2025“…</p>Results and discussion<p>At 17 years, mean INSL3 is not yet maximal, with high variance due to both longitudinal (timing of pubertal trajectory) and cross-sectional influences, whereas at 24 years, circulating INSL3 concentration has stabilized to its final adult status, even showing a small decreasing trend with age. Maximal INSL3 (i.e., peak puberty) was calculated to be at approximately 22 years in this cohort. …”
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2075
Means of sampling data in the Shibing study area.
Published 2025“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”
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2076
Technology roadmap.
Published 2025“…Rational selection and breeding of economic forest species aid in creating ecolabel brands. This small - watershed - scale analysis improves the accuracy of assessing ecological and economic development in karst areas, providing a scientific basis for decision - making to strengthen ecological restoration and enhance people’s well - being.…”
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2077
Image 3_The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.tif
Published 2025“…C-terminal telopeptide (CTX) showed a small, statistically significant reduction (MD −0.09, 95% CI −0.14 to −0.05) with uncertain clinical relevance. …”
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2078
Astrocyte morphology is altered by stretch-induced downregulation of S100B expression.
Published 2025“…On occasion, cells were small in shape and poorly extended (c). Scale bar: 100 μm. …”
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2079
Table 1_Relevance of biochar metabolization—evidence from a long-term biochar field experiment.docx
Published 2025“…Considering the total amounts of biochar added to the soil, BC<sub>m</sub> represents a very small fraction which, for the ecological evaluation of biochar’s dissipation, is negligible.…”
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2080
Table 3_Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity.docx
Published 2025“…</p>Results and discussion<p>At 17 years, mean INSL3 is not yet maximal, with high variance due to both longitudinal (timing of pubertal trajectory) and cross-sectional influences, whereas at 24 years, circulating INSL3 concentration has stabilized to its final adult status, even showing a small decreasing trend with age. Maximal INSL3 (i.e., peak puberty) was calculated to be at approximately 22 years in this cohort. …”