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Showing 281 - 300 results of 487 for search '((dramatic decrease) OR (somatic decrease))', query time: 0.15s Refine Results
  1. 281

    Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx by Fumiya Ito (14833366)

    Published 2025
    “…The resulting ER cells exhibited a dramatic increase in erlotinib resistance, a decreased EGFR protein level, and enhanced tumor growth, suggesting a robust mechanism bypassing EGFR inhibition. …”
  2. 282

    Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf by Fumiya Ito (14833366)

    Published 2025
    “…The resulting ER cells exhibited a dramatic increase in erlotinib resistance, a decreased EGFR protein level, and enhanced tumor growth, suggesting a robust mechanism bypassing EGFR inhibition. …”
  3. 283

    Supplementary data.xlsx by Danjun Li (21443051)

    Published 2025
    “…However, recent studies have indicated that the telomere length of somatic cells can be drastically decreased in the offspring receiving in vitrofertilization (IVF) therapy, however, the underlying molecular mechanism remains unknown. …”
  4. 284

    Data Sheet 1_Large, but short-term, increase in fecal indicator bacteria following extreme flooding from Hurricane Harvey in Houston, TX.docx by Maitreyee Mukherjee (10860393)

    Published 2024
    “…After 1 week, E. coli levels decreased to <100 MPN 100 ml<sup>−1</sup>. Total Bacteroidales numbers were elevated immediately following the hurricane and remained high for 12 days. …”
  5. 285

    Joest et al. - Incomplete Milking during peak to mid Lactation - Supplemental.pdf by Robin Joest (20540378)

    Published 2025
    “…Using software for controlled automated earlier cluster removal, gradual IM led to short-term reductions in milk yield and high variation in milk fat content whereas udder health and stable somatic cell counts were preserved. Blood analysis revealed shifts in energy metabolism, including decreased serum fatty acids and increased insulin-like growth factor 1 (IGF-1). …”
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  10. 290

    Identification of narciclasine as a novel NRF2 inhibitor by Hoang Hai Ngo (20564072)

    Published 2025
    “…<p>Cancer genome sequencing studies have identified somatic mutations in the KEAP1/NRF2 pathway. In an effort to identify novel NRF2 small molecule inhibitor(s), we have screened a natural compound library comprising 1330 chemicals in A549-ARE-GFP-luciferase cells and identified that narciclasine significantly inhibits NRF2-dependent luciferase activity. …”
  11. 291

    Data Sheet 1_Dose-dependent effects of biochar amendment on early rice seedling growth and nursery substrate properties in Southern China.pdf by Liming Chen (113761)

    Published 2025
    “…Conversely, the 40% and 50% treatments had inhibitory effects, resulting in significant reductions in seedling leaf length, stem base width (decreased by 24.9%), dry weight, and leaf area. Root fresh weight also decreased by 11.9%–17.1%. …”
  12. 292

    Table 1_Cannabidiol reduces synaptic strength and neuronal firing in layer V pyramidal neurons of the human cortex with drug-resistant epilepsy.docx by Vladimir A. Martinez-Rojas (21758372)

    Published 2025
    “…At the cellular level, whole-cell patch-clamp recordings showed that CBD decreased the excitability of layer V pyramidal neurons, as evidenced by changes in the somatic input resistance, the membrane time constant, the hyperpolarization-induced “sag” conductance, the rheobase current needed to elicit an action potential, and the firing discharge in response to depolarizing current steps. …”
  13. 293

    JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

    Published 2025
    “…(C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”
  14. 294

    Supplementary file 1_Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.zip by Bistra B. Nankova (21576839)

    Published 2025
    “…Maternal antibiotics during nursing caused: (1) microbial dysbiosis in the offspring as evident by markedly enlarged ceca, no detectable by-products of bacterial fermentation (sp. SCFA) and dramatic changes in microbial composition, diversity (reduced - alpha Chao1and beta Bray-Curtis, as compared to their respective controls) and predictive metabolic activity; (2) alteration in the transcriptional signature of the adrenal medullae and attenuated peripheral stress responses in male offspring, associated with gap junction signaling pathways; (3) increased anxiety-like testing metrics, and decreased locomotor activity; all in a sexually dimorphic manner.…”
  15. 295

    Scale and environmental data for the analysis of year class growth of coregonids from Lake Starnberg by Maxim Teichert (20796416)

    Published 2025
    “…During the observed period, phosphorus concentrations decreased, indicating reduced nutrient availability, whereas spring temperatures showed no significant long-term trend. …”
  16. 296

    Table 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.docx by Nourhen Agrebi (14151222)

    Published 2025
    “…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”
  17. 297

    Data Sheet 1_Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management.pdf by Nourhen Agrebi (14151222)

    Published 2025
    “…Background<p>Hyper-IgM syndrome (HIGM) is a genetic immunodeficiency characterized by elevated to normal IgM levels and decreased IgG, IgA, and IgE. The overlapping clinical presentations of different gene mutations complicate diagnosis and management.…”
  18. 298

    Supplementary file 1_Haptic feedback as affective amplifier: enhanced fear perception affects cognitive performance and avoidance actions in VR height exposure.docx by Lin Cong (191862)

    Published 2025
    “…The integration of physiological, behavioral, and subjective measures provides a mechanistic model for affective-motor competition, demonstrating how somatic threat cues translate into altered actions.…”
  19. 299

    Supplemental Tables for "Hypoxia-inducible factor 1alpha is required to establish the larval glycolytic program in <i>Drosophila melanogaster</i>" by Jason Tennessen (18762937)

    Published 2025
    “…<p dir="ltr"><b>Objectives:</b> The rapid growth that occurs during <i>Drosophila</i> larval development requires a dramatic rewiring of central carbon metabolism to support biosynthesis. …”
  20. 300

    Data Sheet 1_Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism.pdf by Anna Bogusławska (20293545)

    Published 2025
    “…<p>McCune–Albright syndrome (MAS) is a rare genetic disorder caused by somatic activating variants of the GNAS gene. Due to the mosaic state of the variants, the clinical presentation of MAS varies widely depending on the tissues involved. …”