Different Niemann-Pick C1 Genotypes Generate Protein Phenotypes that Vary in their Intracellular Processing, Trafficking and Localization حسب Shammas, Hadeel

"…In 95% of patients the gene encoding NPC1 is affected. The correlation of the genetic background in NP-C with the clinical phenotype such as, severity and onset of liver dysfunction, ataxia, dystonia and vertical gaze palsy, has not been elucidated at the molecular level. …"
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SOAP processing performance and enhancement حسب Tekli, Joe M.

"…Similarity evaluation and differential encoding have thus emerged as SOAP performance enhancement techniques. …"
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Genome sequencing and comparative analysis of an NDM-1-producing Klebsiella pneumoniae ST15 isolated from a refugee patient حسب Tokajian, S.

"…Resistome analysis revealed the presence of several β-lactamases including NDM-1, SHV-28, CTX-M-15 and OXA-1 in addition to 18 other genes encoding for resistance, among which are aph(3')-Ia, aac(6')Ib-cr, armA, strB, strA and aadA2 genes. …"
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Origin and evolution of European community-acquired methicillin-resistant staphylococcus aureus حسب Tokajian, Sima

"…Moreover, the tree topology suggests a single acquisition of both the SCCmec element and a plasmid encoding the fusidic acid resistance determinant. Four canonical SNPs distinguish the derived CA-MRSA lineage and include a nonsynonymous mutation in accessory gene regulator C (agrC). …"
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Bioexploration and Phylogenetic Placement of Entomopathogenic Fungi of the Genus Beauveria in Soils of Lebanon Cedar Forests حسب Charbel Al Khoury (13167975)

"…Morphological features and multilocus phylogeny—based on Sanger sequencing of the transcripts encoding the translation elongation factor 1-alpha (TEF-α), RNA polymerase II second largest subunit (RBP2), and the nuclear intergenic region (Bloc) were used for species identification. …"

Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents حسب Maria K. Smatti (4675852)

"…Specifically, genetic variants in genes encoding virus receptors, antigen presentation, cytokine production, or related to immune cells activation and differentiation could influence how an individual responds to vaccination. …"

Molecular characterization of carbapenem resistant klebsiella pneumoniae and klebsiella quasipneumoniae isolated from Lebanon. (c2018) حسب Arabaghian, Harout K.

"…Resistance was assessed by performing antibiotic susceptibility testing (AST) and PCRs for the most common extended-spectrum β-lactamase and carbapenemase encoding genes. Virulence was studied by sequencing the wzi gene and determinants confirmed in silico. …"
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Comparative genomic analysis of Staphylococcus aureus CC80 strains. (c2015) حسب Bilen, Melhem E.

"…The detection of rare SCCmec cassettes along with rare combination of toxin encoding genes, resistance factors and other virulence determinants could be indicative of MRSA clones being imported and warrants further studies to better understand and deal with such strains.…"
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Subsarcolemmal cAMP signals monitored by cyclic nucleotide gated channels in hypertrophied cardiac myocytes حسب Abi-Gerges, Aniella

"…Isolated left ventricular myocytes from both groups were infected with an adenovirus encoding a mutant of the olfactory cyclic nucleotide-gated (CNG) channels D subunit (E583M C460W CNGA2). …"
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Autologous Transplantation of Amniotic Fluid-Derived Mesenchymal Stem Cells Into Sheep Fetuses حسب Abi Nader, Khalil

"…Those cells were transduced using an HIV vector encoding enhanced green fluorescent protein (GFP) with 63.2% (range 38.3‐96.2%) transduction efficiency rate. …"
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WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon حسب Zallloua, Pierre A.

"…Of the 38 patients identified with homozygous or compound heterozygous WFS1 mutations, 11 (29%) had non-syndromic DM, all of whom carried a particular WFS1 mutation, WFS1LIB, encoding a protein with an extended C-terminal domain. …"
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Exploring the Fecal miRNA Profile in FMF Patients and the Role of miR-21-5p in Inflammatory Pathways Associated with FMF Pathogenesis حسب Chaaban, Ahlam

"…Introduction: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease caused by mutations in the MEFV gene encoding pyrin, a key inflammatory regulator. In addition to genetic factors, epigenetics seems to play an important role in the manifestation of FMF. …"
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Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice حسب Leroy, Jerome

"…Multiple cyclic nucleotide phosphodiesterases (PDEs) regulate local cAMP concentration in cardiomyocytes, with PDE4 being predominant for the control of β-AR–dependent cAMP signals. Three genes encoding PDE4 are expressed in mouse heart: Pde4a, Pde4b, and Pde4d. …"
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Diversity of Bacillus thuringiensis Strains From Qatar as Shown by Crystal Morphology, δ-Endotoxins and Cry Gene Content حسب Kavita Nair (17151127)

"…In addition to strains harboring genes encoding common endotoxins, the majority are different and very promising for the search of novel insecticidal endotoxins.…"

Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System حسب Karim E. Shalaby (12267224)

"…CRISPR components are typically delivered to cells as either a Cas9/sgRNA ribonucleoprotein (RNP) complex or a plasmid encoding a Cas9 protein along with a sequence-specific sgRNA. …"

The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer حسب Ettaib El Marabti (23276158)

"…These isoforms and their encoded proteins are not insignificant byproducts of the abnormal physiology of cancer cells, but either drivers of cancer progression or small but significant contributors to specific cancer hallmarks. …"

Hereditary disease widespread in Syria حسب Nature Research (16552612)

"…Congenital adrenal hyperplasia (CAH) is an inherited metabolic disorder in which mutations in genes encoding enzymes lead to dysregulation in production of the sex hormone androgen. …"

DPI_CDF: druggable protein identifier using cascade deep forest حسب Muhammad Arif (769250)

"…Then a hierarchical deep forest model fuses these three encoding schemes to build the proposed model DPI_CDF.…"

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression حسب Reem Saleh (3513056)

"…Reports showed that the promoter regions of genes encoding ICs/IC ligands can undergo inherent epigenetic alterations, such as DNA methylation and histone modifications (acetylation and methylation). …"

Development and evaluation of real-time polymerase chain reaction assays on whole blood and paraffin-embedded tissues for rapid diagnosis of human brucellosis حسب Zalloua, Pierre A.

"…Three assays with hybridization probe detection on the LightCycler™ instrument were developed and compared targeting the 16S–23S internal transcribed spacer region (ITS) and the genes encoding for omp25 and omp31. All assays showed 100% analytical sensitivity and 100% specificity when tested on 28 consecutive clinical isolates of Brucella sp. and 19 clinical isolates of common Gram-negative and Gram-positive bacterial pathogens, respectively. …"
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