Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response حسب Radhakrishnan Vishnubalaji (3563306)

"…Several interferon (IFN) responsive gene targets (IRF9, IFIT1, IFIT2, IFIT3, IFITM1, MX1, OAS2, OAS3, IFI44 and IFI44L) were highly upregulated in SARS-CoV-2 infected NBHE cell, implying activation of antiviral IFN innate response. Gene ontology and functional annotation of differently expressed genes in patient lung tissues with COVID-19 revealed activation of antiviral response as the hallmark. …"

Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice حسب Zhang, Lei

احصل على النص الكامل

Transcriptomic Analyses of Myeloid-Derived Suppressor Cell Subsets in the Circulation of Colorectal Cancer Patients حسب Varun Sasidharan Nair (5396393)

"…The sorted subsets included polymorphonuclear/granulocytic MDSCs (PMN-MDSCs), immature MDSCs (I-MDSCs), and monocytic MDSCs (M-MDSCs). Our functional annotation analyses revealed that multiple pathways including DNA damage-, chemotaxis-, apoptosis-, mitogen-activated protein kinase-, transforming growth factor β-, and myeloid differentiation–related transcripts were higher in PMN-MDSCs, compared with monocytic antigen-presenting cells (APCs) or I-MDSCs. …"

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer حسب Varun Sasidharan Nair (5396393)

"…</p><h3>Results</h3><p dir="ltr">We found that the levels of I-MDSCs and PMN-MDSCs were increased in tumor tissues (TT), compared with normal tissues (NT) in colorectal cancer. Our functional annotation analyses showed that genes associated with histone deacetylase (HDAC) activation- and DNA methylation-mediated transcriptional silencing were upregulated, and histone acetyl transferase (HAT)-related genes were downregulated in tumor-infiltrating I-MDSCs. …"

Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer حسب Hibah Shaath (5599658)

"…Computational analyses using Ingenuity Pathway Analysis (IPA) identified multiple activated signaling networks in CRC, including ERBB2, RABL6, FOXM1, and NFKB networks, while functional annotation highlighted activation of cell proliferation and migration as the hallmark of CRC. …"

Channelpedia حسب Khazen, Georges

"…Ion channels are membrane proteins that selectively conduct ions across the cell membrane. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Predictive Engineering the Membrane Composition of Neocortical Neurons حسب Khazen, Georges

"…In the second study, I present a physical constrain checker that mines different publicly available data resources regarding all known membrane proteins such as channels and receptors, and extracts available information relating to their specific location on different parts of the neuronal morphologies, their 3D morphological structures as well as their genetic and proteomic annotations. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

A Systems-level Characterization of the Differentiation of Human Embryonic Stem Cells into Mesenchymal Stem Cells*[S] حسب Anja M. Billing (1297773)

"…Exploring the kinetic of noncoding ORFs during differentiation, we mapped new functions to well annotated long noncoding RNAs (CARMN, MALAT, NEAT1, LINC00152) as well as new candidates which we identified to be important to the differentiation process. …"