Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition de réir Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Biochemical validation of NSC124205. de réir Anjelika Gasilina (8566296)

“…Lysates (30 μg) were resolved on 12% SDS-PAGE, transferred, and blotted for pAKT and pERK1/2. …”

Formation of a circular chromosome in MD741-18. de réir Lei Qi (173882)

“…<p><b>(A)</b> By genomic sequence analysis, the strain MD741-18 had T-DELs on both the left and right arms of chromosome XV, but no T-DUPs on other chromosomes. …”

Analysis of Time to Event Outcomes in Randomized Controlled Trials by Generalized Additive Models de réir Christos Argyropoulos (60264)

“…These in turn were used to calculate relative and absolute risks or even differences in restricted mean survival time between treatment arms. We illustrate our approach with extensive simulations and in two trials: IPASS (in which the proportionality of hazards was violated) and HEMO a long duration study conducted under evolving standards of care on a heterogeneous patient population.…”

Image_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.TIFF de réir Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Table_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.DOCX de réir Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Working with communities to mobilise evidence and knowledge webinar de réir Naeema Ahmed (19865434)

“…In this webinar we will hear from our community partners, AFRUCA, who lead our focus on community involvement and health inequalities, ensuring our work contributes to reducing disparities.…”

Table_1_Case report: Identification of facioscapulohumeral muscular dystrophy 1 in two siblings with normal phenotypic parents using optical genome mapping.xlsx de réir Jieni Jiang (17881814)

“…Both the proband and her younger brother were found to display asymmetric weakness predominantly involving the facial, shoulder girdle, and upper arm muscles, whereas the younger brother had more severe clinical symptoms. …”