Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition per Yingxin Zhao (49232)

“…Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. …”

Biochemical validation of NSC124205. per Anjelika Gasilina (8566296)

“…Lysates (30 μg) were resolved on 12% SDS-PAGE, transferred, and blotted for pAKT and pERK1/2. …”

Formation of a circular chromosome in MD741-18. per Lei Qi (173882)

“…<p><b>(A)</b> By genomic sequence analysis, the strain MD741-18 had T-DELs on both the left and right arms of chromosome XV, but no T-DUPs on other chromosomes. …”

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals per Ana Lemos de Matos (469331)

“…Host innate sentinel proteins involved in pathogen recognition must rapidly evolve in a dynamic arms race with pathogens, and thus are subjected to long-term positive selection pressures to avoid potential infections. …”

Analysis of Time to Event Outcomes in Randomized Controlled Trials by Generalized Additive Models per Christos Argyropoulos (60264)

“…These in turn were used to calculate relative and absolute risks or even differences in restricted mean survival time between treatment arms. We illustrate our approach with extensive simulations and in two trials: IPASS (in which the proportionality of hazards was violated) and HEMO a long duration study conducted under evolving standards of care on a heterogeneous patient population.…”

Image_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.TIFF per Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Table_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.DOCX per Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Working with communities to mobilise evidence and knowledge webinar per Naeema Ahmed (19865434)

“…In this webinar we will hear from our community partners, AFRUCA, who lead our focus on community involvement and health inequalities, ensuring our work contributes to reducing disparities.…”

Table_1_Case report: Identification of facioscapulohumeral muscular dystrophy 1 in two siblings with normal phenotypic parents using optical genome mapping.xlsx per Jieni Jiang (17881814)

“…Both the proband and her younger brother were found to display asymmetric weakness predominantly involving the facial, shoulder girdle, and upper arm muscles, whereas the younger brother had more severe clinical symptoms. …”

Table_2_Effect of Tai Chi Chuan in Breast Cancer Patients: A Systematic Review and Meta-Analysis.docx per Xiao-Chao Luo (8750853)

“…</p><p>Results: Fifteen articles involving a total of 885 breast cancer participants were included in this review. …”

Table_1_A study of the risk factors for phlebitis in patients stratified using the acute physiology and chronic health evaluation II score and admitted to the intensive care unit:... per Yuki Kishihara (9950347)

“…</p>Materials and methods<p>This study was a post hoc analysis of the AMOR-VENUS study involving 23 ICUs in Japan. We included patients with age ≥ 18 years and consecutive admissions to the ICU with PIVCs inserted during ICU admission. …”

Hydrogenation of Dimethyl Carbonate to Methanol by <i>trans</i>-[Ru(H)₂(PNN)(CO)] Catalysts: DFT Evidence for Ion-Pair-Mediated Metathesis Paths for C–OMe Bond Cleavage... per Faraj Hasanayn (1712818)

“…A mechanism for this reaction was proposed on the basis of (i) carbonyl group insertion into one of the Ru–H bonds to produce the six-coordinate <i>trans</i>-[Ru­(OCH­(OMe)₂)­(H)­(PNN)­(CO)] intermediate and (ii) a metal–ligand cooperative transformation, involving proton transfer from the phosphine arm of the PNN ligand to a methoxy group of the Ru-coordinated [OCH­(OMe)₂]⁻ anion along with cleavage of a C–OMe bond, to produce methanol and an O-bound methyl formate complex of the dearomatized square-pyramidal form of the catalyst, [Ru­(H)­(PNN)­(CO)]. …”

Image_3_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.tiff per Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Table_3_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.DOCX per Lin Liu (74495)

“…Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. …”

Data_Sheet_1_“We want more”: perspectives of sarcopenic older women on the feasibility of high-intensity progressive resistance exercises and a whey-protein nutrition intervention.... per Reena K. Vijayakumaran (16945773)

“…<p>This qualitative study is nested within a 12-week pilot randomized-controlled, two-arm trial involving high-intensity progressive resistance training (PRT) or PRT with a multi-nutrient, whey-protein supplementation (PRT+WP) in sarcopenic older adults (trial registration no: TCTR20230703001). …”