Image5_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff حسب Michela Lisjak (12228038)

"…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …"

Image1_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff حسب Michela Lisjak (12228038)

"…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …"

Image4_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff حسب Michela Lisjak (12228038)

"…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …"

Image2_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff حسب Michela Lisjak (12228038)

"…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …"

Table1_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.pdf حسب Michela Lisjak (12228038)

"…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …"

DataSheet_1_PTCH1 and CTNNB1 emerge as pivotal predictors of resistance to neoadjuvant chemotherapy in ER+/HER2- breast cancer.docx حسب Gulnihal Ozcan (9673713)

"…The dual function of PTCH1 as a multidrug efflux pump and a hedgehog receptor, and the active involvement of CTNNB1 in breast cancer strongly indicate that PTCH1 and CTNNB1 can be potential drug targets to overcome chemoresistance in ER +/HER2- breast cancer patients.…"

From Town Assemblies to Representative Democracy: The Building of Electoral Institutions in Nineteenth-Century Chile حسب J.Samuel Valenzuela (18888124)

"…The paper then explores in a final section how the system evolved until the crucial electoral reform of 1890 that allowed the Chilean regime to transition from a proto-democracy to a democratic regime, albeit one with an incomplete extension of the suffrage given the absence of voting rights for women and for the dwindling half of the population that then was illiterate. …"

Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures حسب Antonio Augusto Velasco e Cruz (5761643)

"…Methods: Surgical description: The main steps of the procedure consisted of exposure of the entire tarsal plate up to the eyelashes followed by tarsotomy through the conjunctiva. A double-armed 6.0 polyglactin suture was then passed through the distal tarsal fragment to the marginal section of the orbicularis oculi muscle. …"

(A) Creation of a genetic rescue construct encoding fused with an N-terminal FLAG-tetracysteine tag (4C), حسب Jaroslaw Kasprowicz (90262)

"…(b) PCR product containing left (L) and right (R) homology arms, the 4C tag, and LoxP site (gray triangles) flanked marker. …"

A gene expression signature of spontaneous metastasis in a K-ras/p53 mutant mouse model. حسب Don L. Gibbons (171057)

"…Log rank test evaluates whether there are significant differences between the two arms. Univariate Cox test evaluates the association of the met signature t-score with patient outcome, treating the coefficient as a continuous variable. …"

Background Selection as Baseline for Nucleotide Variation across the <i>Drosophila</i> Genome حسب Josep M. Comeron (128554)

"…<div><p>The constant removal of deleterious mutations by natural selection causes a reduction in neutral diversity and efficacy of selection at genetically linked sites (a process called Background Selection, BGS). …"

Emergency Anterior Bilateral Thoracotomy حسب Claudia Villanueva (13584616)

"…</p><p dir="ltr">Blood clots were removed to release the tamponade and the heart was inspected for any lacerations. …"

Table_1_Source localized infraslow neurofeedback training in people with chronic painful knee osteoarthritis: A randomized, double-blind, sham-controlled feasibility clinical trial... حسب Jerin Mathew (12220631)

"…Eligible participants attended nine 30-min ISF-NF training sessions involving three cortical regions linked to pain. Feasibility measures were monitored during the trial period. …"

DataSheet_2_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv حسب Katharine Yu (5688425)

"…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…"

Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery: A Multi-Center Randomized Controlled Trial and Meta-Analysis حسب Chuan Zhang (187157)

"…</p><p>Methods</p><p>We conducted a randomized open-label controlled trial with two parallel arms at three hospitals in western China. Participants meeting the inclusion criteria received antibiotics 30-60 minutes before skin incision while others received antibiotics after umbilical cords clamping. …"

Table1_Effectiveness and safety of pelareorep plus chemotherapy versus chemotherapy alone for advanced solid tumors: a meta-analysis.docx حسب Renxian Xie (17044863)

"…</p><p>Results: There were five studies involving 492 patients included in the study. Combination therapy did not significantly improve clinical outcomes in terms of 1-year OS [RR = 1.02, 95%CI = (0.82–1.25)], 2-year OS [RR = 1.00, 95%CI = (0.67–1.49)], 4-month PFS [RR = 1.00, 95%CI = (0.67–1.49)], 1-year PFS [RR = 0.79, 95%CI = (0.44–1.42)], and ORR [OR = 0.79, 95%CI = (0.49–1.27)] compared to chemotherapy alone, and the subgroup analysis of 2-year OS, 1-year PFS, and ORR based on countries and tumor sites showed similar results. …"

Early Sitting in Ischemic Stroke Patients (SEVEL): A Randomized Controlled Trial حسب Fanny Herisson (685067)

"…Taking these limitations into account, our results may help guide the development of more effective acute stroke rehabilitation strategies, and the design of future acute stroke trials involving out of bed activities and other mobilization regimens.…"

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv حسب Katharine Yu (5688425)

"…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…"

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.docx حسب Katharine Yu (5688425)

"…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…"

Conditional Chr 13 <i>PRELI</i> gene Targeting. حسب Wenbin Ma (320902)

"…Also indicated are 5′ and 3′ arms of homology, LoxP sites, Flip recombination (Frt) sequences, and PGK-Neo and HSV-Tk selection cassettes; <b>III</b>: Floxed <i>PRELI</i> allele, after Frt-mediated removal of selection cassettes; <b>IV</b>: <i>PRELI</i> deficient allele after CD19-driven Cre recombinase (Cre) cleavage of <i>PRELI</i> exon II. …"