Image4_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff por Michela Lisjak (12228038)

“…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …”

Image2_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.tiff por Michela Lisjak (12228038)

“…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …”

Table1_Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice.pdf por Michela Lisjak (12228038)

“…<p>Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. …”

DataSheet_1_PTCH1 and CTNNB1 emerge as pivotal predictors of resistance to neoadjuvant chemotherapy in ER+/HER2- breast cancer.docx por Gulnihal Ozcan (9673713)

“…The dual function of PTCH1 as a multidrug efflux pump and a hedgehog receptor, and the active involvement of CTNNB1 in breast cancer strongly indicate that PTCH1 and CTNNB1 can be potential drug targets to overcome chemoresistance in ER +/HER2- breast cancer patients.…”

Chromosome synteny between <i>C. elegans</i> and <i>C. briggsae</i>. por Joseph A. Ross (213788)

“…Extensive synteny is evident in the low-recombining central domains of all chromosomes; synteny is not apparent when comparing the chromosome arms between species.</p>…”

Clamshell Approach for Growing Teratoma Syndrome por Sara Parini (10189308)

“…The left superior pulmonary vein was encircled to ensure its control in case of lung involvement. The underlying left lung was freed of the compressing mass, which was a 2500 g tumor measuring 23 x 16 x 15 cm. …”

Structural imaging mode. por Matthieu Palayret (725929)

Recombination Is Initiated by Double-Strand Breaks por Rhona H Borts (583501)

“…This pathway results in the exchange of chromosome arms as illustrated in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000106#pbio-1000106-g001" target="_blank">Figure 1</a>. …”

Table_1_Source localized infraslow neurofeedback training in people with chronic painful knee osteoarthritis: A randomized, double-blind, sham-controlled feasibility clinical trial... por Jerin Mathew (12220631)

“…Eligible participants attended nine 30-min ISF-NF training sessions involving three cortical regions linked to pain. Feasibility measures were monitored during the trial period. …”

DataSheet_2_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery: A Multi-Center Randomized Controlled Trial and Meta-Analysis por Chuan Zhang (187157)

“…</p><p>Methods</p><p>We conducted a randomized open-label controlled trial with two parallel arms at three hospitals in western China. Participants meeting the inclusion criteria received antibiotics 30-60 minutes before skin incision while others received antibiotics after umbilical cords clamping. …”

Table1_Effectiveness and safety of pelareorep plus chemotherapy versus chemotherapy alone for advanced solid tumors: a meta-analysis.docx por Renxian Xie (17044863)

“…</p><p>Results: There were five studies involving 492 patients included in the study. Combination therapy did not significantly improve clinical outcomes in terms of 1-year OS [RR = 1.02, 95%CI = (0.82–1.25)], 2-year OS [RR = 1.00, 95%CI = (0.67–1.49)], 4-month PFS [RR = 1.00, 95%CI = (0.67–1.49)], 1-year PFS [RR = 0.79, 95%CI = (0.44–1.42)], and ORR [OR = 0.79, 95%CI = (0.49–1.27)] compared to chemotherapy alone, and the subgroup analysis of 2-year OS, 1-year PFS, and ORR based on countries and tumor sites showed similar results. …”

Early Sitting in Ischemic Stroke Patients (SEVEL): A Randomized Controlled Trial por Fanny Herisson (685067)

“…Taking these limitations into account, our results may help guide the development of more effective acute stroke rehabilitation strategies, and the design of future acute stroke trials involving out of bed activities and other mobilization regimens.…”

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.docx por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

Transposition Is Targeted to Structures, Not Sequences por Jennifer E Posey (21929)

“…One plasmid stably maintains a linear inverted repeat; the other forms a stable cruciform, with two extruded hairpin arms.</p> <p>(B) Transposition is stimulated by cruciform structures. …”

Robotic-Assisted Middle Lobe Sleeve Lobectomy for Carcinoid Tumor por Kenji Kawamukai (13863640)

“…</p> <p>Preoperative bronchoscopy confirmed the involvement of the insertion of middle lobe bronchus. …”

Modulated Preparation and Structural Diversification of Zn^II and Cd^II Metal−Organic Frameworks with a Versatile Building Block 5-(4-Pyridyl)-1,3,4-oxadiazole-... por Miao Du (1399054)

“…Four types of binding modes involving monodentate (η-<i>N</i>_oxa), bidentate (μ-<i>N</i>_py,<i>N</i>_oxa, or μ-<i>N</i>_py,<i>S</i>,<i>S</i>) and tridentate (μ-<i>N</i>_py,<i>N</i>_oxa,<i>S</i>) are observed. …”

Data_Sheet_1_The efficacy and safety of different endovascular modalities for infrapopliteal arteries lesions: A network meta-analysis of randomized controlled trials.docx por Julong Guo (12986249)

“…In total, 22 eligible RCTs (44 study arms; 1,348 patients) involving nine endovascular modalities or combinations [balloon angioplasty (BA), drug-coated balloon (DCB), drug-eluting stent (DES), atherectomy device + BA (AD + BA), AD + DCB, balloon-expandable bare metal stent (BMS), self-expanding stent (SES), absorbable metal stents (AMS), and inorganics-coated stent (ICS)] were included. …”

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs por Lin Zhu (192179)

“…During this evolutionary arms race between human and virus, SARS-CoV-2 tries to improve its <i>cis</i> elements to compete with host RNAs for rapid translation.…”