Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction od Patrick S. Mitchell (264819)

“…The myxovirus resistance (<i>Mx</i>) genes encode interferon-inducible GTPases that constitute a major arm of the cell-autonomous defense against viral infection. …”

Table 1_Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree.docx od Wiktor Olszewski (22679396)

“…Regardless of treatment arm, there was substantial increase in NWU during the first 24 h and 1 week post-stroke. …”

Quantifying Adaptive Evolution in the <em>Drosophila</em> Immune System od Darren J. Obbard (204318)

“…To quantify the effect, and to identify which genes and pathways are most likely to be involved in the host–parasite arms race, we have re-sequenced population samples of 136 immunity and 287 position-matched non-immunity genes in two species of <em>Drosophila</em>. …”

Table_1_Sexual Selection and the Evolution of Male Reproductive Traits in Benthic Octopuses.DOCX od Christian M. Ibáñez (7062065)

“…We combined data on hectocotylized arm length (HAL), ligula length (LL), spermatophore length (SL) with a Bayesian molecular phylogeny of 87 species, to analyze how reproductive traits have diverged across lineages and covary with body size (mantle length; ML). …”

Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI: Randomized, Placebo-Controlled Phase II Clinical Trial in Patients with Latent Tuberculosis Infe... od Andre S. Nell (527702)

“…Two subjects had serious adverse events one had a retinal detachment while taking INH and was not randomized and the other had a severe local injection site abscess on each arm and was hospitalized; causality was assessed as very likely and by the end of the study the outcome had resolved. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition od Yingxin Zhao (49232)

“…However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoproteome changes in response to TGFβ and a specific IKK inhibitor, BMS-345541, revealed that IKK regulates cascades of 23 signaling pathways essential in EMT, including TGFβ signaling, p38 mitogen associate protein kinase (MAPK), Toll receptor signaling, and integrin pathways. …”

Table_1_Predictable Molecular Adaptation of Coevolving Enterococcus faecium and Lytic Phage EfV12-phi1.DOCX od Stephen Wandro (5016434)

“…Genome sequencing revealed that E. faecium evolved resistance to phage through mutations in the yqwD2 gene involved in exopolysaccharide biogenesis and export, and the rpoC gene which encodes the RNA polymerase β’ subunit. …”

Image_1_Predictable Molecular Adaptation of Coevolving Enterococcus faecium and Lytic Phage EfV12-phi1.pdf od Stephen Wandro (5016434)

“…Genome sequencing revealed that E. faecium evolved resistance to phage through mutations in the yqwD2 gene involved in exopolysaccharide biogenesis and export, and the rpoC gene which encodes the RNA polymerase β’ subunit. …”