Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI: Randomized, Placebo-Controlled Phase II Clinical Trial in Patients with Latent Tuberculosis Infe... по Andre S. Nell (527702)

“...Two subjects had serious adverse events one had a retinal detachment while taking INH and was not randomized and the other had a severe local injection site abscess on each arm and was hospitalized; causality was assessed as very likely and by the end of the study the outcome had resolved. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Crosstalk of the IκB Kinase with Spliced X‑Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial–Mesenchymal Transition по Yingxin Zhao (49232)

“...Interestingly, we found that IKKβ directly complexes with and phosphorylates the spliced X-box-binding protein 1 (XBP1s). XBP1s is an arm of the unfolded protein response (UPR) that activates the hexosamine biosynthetic pathway (HBP), a pathway that mediates protein N-glycosylation and survival from ER stress-induced apoptosis in EMT. ...”

Biochemical validation of NSC124205. по Anjelika Gasilina (8566296)

“...Lysates (30 μg) were resolved on 12% SDS-PAGE, transferred, and blotted for pAKT and pERK1/2. ...”

Formation of a circular chromosome in MD741-18. по Lei Qi (173882)

“...<p><b>(A)</b> By genomic sequence analysis, the strain MD741-18 had T-DELs on both the left and right arms of chromosome XV, but no T-DUPs on other chromosomes. ...”

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals по Ana Lemos de Matos (469331)

“...Host innate sentinel proteins involved in pathogen recognition must rapidly evolve in a dynamic arms race with pathogens, and thus are subjected to long-term positive selection pressures to avoid potential infections. ...”

Analysis of Time to Event Outcomes in Randomized Controlled Trials by Generalized Additive Models по Christos Argyropoulos (60264)

“...These in turn were used to calculate relative and absolute risks or even differences in restricted mean survival time between treatment arms. We illustrate our approach with extensive simulations and in two trials: IPASS (in which the proportionality of hazards was violated) and HEMO a long duration study conducted under evolving standards of care on a heterogeneous patient population....”

Image_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.TIFF по Lin Liu (74495)

“...Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. ...”

Table_1_Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.DOCX по Lin Liu (74495)

“...Highly differentiated genes included gpi, mphG, armA, msrE, adec, catB8, aadA, sul1, bla_OXA–₄₃₅, aph3i, and bla_TEM–₁, which may represent gene markers for TgcR A. baumannii sub-types. ...”