DataSheet_1_PTCH1 and CTNNB1 emerge as pivotal predictors of resistance to neoadjuvant chemotherapy in ER+/HER2- breast cancer.docx por Gulnihal Ozcan (9673713)

“…The dual function of PTCH1 as a multidrug efflux pump and a hedgehog receptor, and the active involvement of CTNNB1 in breast cancer strongly indicate that PTCH1 and CTNNB1 can be potential drug targets to overcome chemoresistance in ER +/HER2- breast cancer patients.…”

Chromosome synteny between <i>C. elegans</i> and <i>C. briggsae</i>. por Joseph A. Ross (213788)

“…Extensive synteny is evident in the low-recombining central domains of all chromosomes; synteny is not apparent when comparing the chromosome arms between species.</p>…”

Analysis of México’s Narco-War Network (2007–2011) por Jesús Espinal-Enríquez (622164)

“…<div><p>Since December 2006, more than a thousand cities in México have suffered the effects of the war between several drug cartels, amongst themselves, as well as with Mexican armed forces. Sources are not in agreement about the number of casualties of this war, with reports varying from 30 to 100 thousand dead; the economic and social ravages are impossible to quantify. …”

Plant DNA destruction by a secreted fungal effector of bacterial origin modulates host immunity por Chunmei Yin (9587744)

“…Small secreted effector proteins are deployed by parasitic fungi to target plant defense machinery and suppress host innate immunity mechanisms, but plants can evolve counter-measures. In the ensuing evolutionary arms race, the pathogen is under strong selective pressure to assemble novel effectors, but whether and where reservoirs of genetic material might exist for such purposes, and how they might furnish novel effector function, is not known, impeding comprehensive understanding of these important mediators of disease. …”

Clamshell Approach for Growing Teratoma Syndrome por Sara Parini (10189308)

“…The left superior pulmonary vein was encircled to ensure its control in case of lung involvement. The underlying left lung was freed of the compressing mass, which was a 2500 g tumor measuring 23 x 16 x 15 cm. …”

Structural imaging mode. por Matthieu Palayret (725929)

Recombination Is Initiated by Double-Strand Breaks por Rhona H Borts (583501)

“…This pathway results in the exchange of chromosome arms as illustrated in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000106#pbio-1000106-g001" target="_blank">Figure 1</a>. …”

Table_1_Source localized infraslow neurofeedback training in people with chronic painful knee osteoarthritis: A randomized, double-blind, sham-controlled feasibility clinical trial... por Jerin Mathew (12220631)

“…Eligible participants attended nine 30-min ISF-NF training sessions involving three cortical regions linked to pain. Feasibility measures were monitored during the trial period. …”

DataSheet_2_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery: A Multi-Center Randomized Controlled Trial and Meta-Analysis por Chuan Zhang (187157)

“…</p><p>Methods</p><p>We conducted a randomized open-label controlled trial with two parallel arms at three hospitals in western China. Participants meeting the inclusion criteria received antibiotics 30-60 minutes before skin incision while others received antibiotics after umbilical cords clamping. …”

Table1_Effectiveness and safety of pelareorep plus chemotherapy versus chemotherapy alone for advanced solid tumors: a meta-analysis.docx por Renxian Xie (17044863)

“…</p><p>Results: There were five studies involving 492 patients included in the study. Combination therapy did not significantly improve clinical outcomes in terms of 1-year OS [RR = 1.02, 95%CI = (0.82–1.25)], 2-year OS [RR = 1.00, 95%CI = (0.67–1.49)], 4-month PFS [RR = 1.00, 95%CI = (0.67–1.49)], 1-year PFS [RR = 0.79, 95%CI = (0.44–1.42)], and ORR [OR = 0.79, 95%CI = (0.49–1.27)] compared to chemotherapy alone, and the subgroup analysis of 2-year OS, 1-year PFS, and ORR based on countries and tumor sites showed similar results. …”

Early Sitting in Ischemic Stroke Patients (SEVEL): A Randomized Controlled Trial por Fanny Herisson (685067)

“…Taking these limitations into account, our results may help guide the development of more effective acute stroke rehabilitation strategies, and the design of future acute stroke trials involving out of bed activities and other mobilization regimens.…”

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.csv por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

DataSheet_1_Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes.docx por Katharine Yu (5688425)

“…Introduction<p>Drug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.…”

Transposition Is Targeted to Structures, Not Sequences por Jennifer E Posey (21929)

“…One plasmid stably maintains a linear inverted repeat; the other forms a stable cruciform, with two extruded hairpin arms.</p> <p>(B) Transposition is stimulated by cruciform structures. …”

Dosage compensation and neo-sex chromosomes in <i>Drosophila</i>. por Christopher Ellison (87115)

“…The ancestral karyotype of <i>Drosophila</i> consists of five large rods (the ancestral X, which is conserved across <i>Drosophila</i>, and the autosomal arms Muller element B, C, D, and E) and the small dot chromosome (Muller element F). …”

Image_2_The Formation of Sex Chromosomes in Silene latifolia and S. dioica Was Accompanied by Multiple Chromosomal Rearrangements.tif por Václav Bačovský (8505372)

“…Although it is generally assumed that the sex chromosomes evolved from a single pair of autosomes, it is difficult to distinguish the ancestral pair of chromosomes in related gynodioecious and hermaphroditic plants. …”

Image_3_The Formation of Sex Chromosomes in Silene latifolia and S. dioica Was Accompanied by Multiple Chromosomal Rearrangements.TIF por Václav Bačovský (8505372)

“…Although it is generally assumed that the sex chromosomes evolved from a single pair of autosomes, it is difficult to distinguish the ancestral pair of chromosomes in related gynodioecious and hermaphroditic plants. …”

Image_4_The Formation of Sex Chromosomes in Silene latifolia and S. dioica Was Accompanied by Multiple Chromosomal Rearrangements.tif por Václav Bačovský (8505372)

“…Although it is generally assumed that the sex chromosomes evolved from a single pair of autosomes, it is difficult to distinguish the ancestral pair of chromosomes in related gynodioecious and hermaphroditic plants. …”

Table_2_The Formation of Sex Chromosomes in Silene latifolia and S. dioica Was Accompanied by Multiple Chromosomal Rearrangements.XLS por Václav Bačovský (8505372)

“…Although it is generally assumed that the sex chromosomes evolved from a single pair of autosomes, it is difficult to distinguish the ancestral pair of chromosomes in related gynodioecious and hermaphroditic plants. …”