A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in <i>Onchocerca volvulus</i> Infection od Kwablah Awadzi (169148)

“…Statistically significantly higher percentages of participants treated with 8 mg moxidectin than participants treated with ivermectin experienced pruritus (87% vs. 56%), rash (63% vs. 42%), increased pulse rate (61% vs. 36%) and decreased mean arterial pressure upon 2 minutes standing still after ≥5 minutes supine relative to pre-treatment (61% vs. 27%). These reactions resolved without treatment. In the 8 mg moxidectin and ivermectin arms, the mean±SD number of microfilariae/mg skin were 22.9±21.1 and 21.2±16.4 pre-treatment and 0.0±0.0 and 1.1±4.2 at nadir reached 1 and 3 months after treatment, respectively. …”

Demographic data and baseline characteristics. od Shyam Sundar (58354)

“…</p><p>Methodology/Principal findings</p><p>An open-label, phase II, randomized, parallel-arm, non-comparative trial was conducted in patients with parasitologically confirmed PKDL, 6 to ≤60 years. …”

Participant flow chart. od Shyam Sundar (58354)

“…</p><p>Methodology/Principal findings</p><p>An open-label, phase II, randomized, parallel-arm, non-comparative trial was conducted in patients with parasitologically confirmed PKDL, 6 to ≤60 years. …”

Supplementary Material for: Comparative Cytogenetic Analysis of Three Eumeninae Species (Hymenoptera, Vespidae) od Tavares M.G. (10788123)

“…Based on the cytogenetic data obtained here, we discuss the possible numerical/structural rearrangements that may be involved in the karyotypic evolution of the 3 studied species. …”

Image_1_The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease.pdf od Gonzalo R. Acevedo (4050676)

“…<p>Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune response in a very complex and flowery manner. …”

Efficacy and Safety of ‘Fixed Dose’ versus ‘Loose’ Drug Regimens for Treatment of Pulmonary Tuberculosis in Two High TB-Burden African Countries: A Randomized Controlled Trial... od Abraham Aseffa (108981)

“…</p><p>Methods</p><p>A two-arm, single-blind, randomized clinical trial comparing FDCs with separate LFs involving 1000 adults newly diagnosed with culture positive PTB was conducted at five sites in two African countries between 2007 and 2011. …”

DataSheet_1_Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring... od Thomas Powles (3502598)

“…Current methods often involve germline sampling, which is not always feasible or practical. …”

DataSheet_1_A Prospective Investigation of Bispecific CD19/22 CAR T Cell Therapy in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma.zip od Ying Zhang (40767)

“…</p>Methods<p>We performed a prospective, single-arm study of bispecific CD19/22 CAR T cells in R/R B-NHL. …”

Text S1 - Considering Usual Medical Care in Clinical Trial Design od Liza Dawson (259048)

“…The meeting was informed by a background paper outlining types of challenges involved in selecting usual care arms, prepared by a working group with expertise in clinical trial design, ethics, evidence-based medicine, statistics, and science policy. …”

Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes od Julia Eckl (4541044)

“…<div><p>Hsp90 is a molecular chaperone involved in the regulation and maturation of kinases and transcription factors. …”

Data_Sheet_1_Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain.zip od Coraline Mercier (16999581)

“…We identify one of two S-layer proteins as primary receptor for HRTV-DL1 and conclude that the presence of two different S-layer proteins in one strain provides a strong advantage in the arms race with viruses. Additionally, we identify archaeal homologs to eukaryotic proteins potentially being involved in the defense against virus infection.…”

Image_6_PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia.TIF od Tansi Khodai (5906126)

“…</p><p>Conclusion: These findings are important as they identify, for the first time, a specific VMH neuronal population involved in glucose homeostasis. Identifying the different glucose-sensing populations in the VMH will help piece together the different arms of glucose regulation providing vital information regarding central responses to glucose metabolic disorders including hypoglycaemia.…”

Image_3_PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia.TIF od Tansi Khodai (5906126)

“…</p><p>Conclusion: These findings are important as they identify, for the first time, a specific VMH neuronal population involved in glucose homeostasis. Identifying the different glucose-sensing populations in the VMH will help piece together the different arms of glucose regulation providing vital information regarding central responses to glucose metabolic disorders including hypoglycaemia.…”

The <i>DFR</i> locus: A smart landing pad for targeted transgene insertion in tomato od Benoit Danilo (6057626)

“…In the present study, we chose the tomato <i>DFR</i> gene involved in anthocyanin biosynthesis as a landing pad for targeted transgene insertion using CRISPR-Cas9 in a two-step strategy. …”

Table_1_Predictable Molecular Adaptation of Coevolving Enterococcus faecium and Lytic Phage EfV12-phi1.DOCX od Stephen Wandro (5016434)

“…Genome sequencing revealed that E. faecium evolved resistance to phage through mutations in the yqwD2 gene involved in exopolysaccharide biogenesis and export, and the rpoC gene which encodes the RNA polymerase β’ subunit. …”

Video_2_Exploratory Analysis of Treading Water Coordination and the Influence of Task and Environmental Constraints.wmv od Chris Button (618933)

“…The four TW patterns used represent a hierarchy of expertise in terms of the capacity to generate continuous lift forces, where pattern 1 (the lowest skill level) involved predominantly pushing and kicking limb movements (N = 1); pattern 2 was a movement pattern consisting of legs pushing/kicking and arms sculling (N = 7); pattern 3 was synchronous sculling of all four limbs (N = 6); and pattern 4 was the “eggbeater kick” (the highest skill level), with asynchronous sculling movements of the legs (N = 9). …”

Image2_Four-Dimensional Printing of Alternate-Actuated Composite Structures for Reversible Deformation under Continuous Reciprocation Loading.JPEG od Guanghao Chu (10818159)

“…These actuators are suitable for non-persistent loads, such as is involved in grabbing action by a 4D printed claw. However, reduced stiffness cannot support continuous external loads during actuation. …”

The Mexican bean beetle (<i>Epilachna varivestis</i>) regurgitome and insights into beetle-borne virus specificity od Cassidy R. Gedling (4804404)

“…<div><p>For nearly 400 million years, insects and plants have been embattled in an evolutionary arms race. Insects have developed diverse feeding strategies and behaviors in an effort to circumvent and overcome an extensive collection of plant defense tactics. …”

Image_2_PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia.TIF od Tansi Khodai (5906126)

“…</p><p>Conclusion: These findings are important as they identify, for the first time, a specific VMH neuronal population involved in glucose homeostasis. Identifying the different glucose-sensing populations in the VMH will help piece together the different arms of glucose regulation providing vital information regarding central responses to glucose metabolic disorders including hypoglycaemia.…”

<i>ZMYND10</i> - Mutation Analysis in Slavic Patients with Primary Ciliary Dyskinesia od Małgorzata Kurkowiak (2177252)

“…While identification of new genes involved in PCD pathogenesis remains crucial, the search for new, population-specific mutations causative for PCD is equally important. …”