X-Linked Tumor Suppressor Genes Act as Presumed Contributors in the Sex Chromosome-Autosome Crosstalk in Cancers nork Bhanupriya Dhabhai (11053816)

“...<p>Since the human genome contains about 6% of tumor suppressor genes (TSGs) and the X chromosome alone holds a substantial share (2%), herein, we have discussed exclusively the relative contribution of X-linked human TSGs that appear to be primarily involved in 32 different cancer types. Our analysis showed that, (a) the majority of X-linked TSGs are primarily involved in the dysregulation of breast cancer, followed by prostate cancer, (b) Despite being escaped from X chromosome inactivation (XCI), a clear pattern of altered promoter methylation linked to the mutational burden was observed among them. ...”

Mechanisms of Chromosome Number Evolution in Yeast nork Jonathan L. Gordon (212846)

“...The other mechanism, seen once, involves the breakage of a chromosome at its centromere, followed by the fusion of the two arms to the telomeres of two other chromosomes. ...”

Supplemental Material for Vicars et al., 2024 nork Hannah Vicars (19861128)

“...<p>  </p> <p>Chromosome congression and alignment on the metaphase plate involves lateral and microtubule plus-end interactions with the kinetochore. ...”

May et al_PBIOLOGY-D-24-01652R2_FACS nork Katja Roeper (20902517)

“...Cells were expressing a fluorescently tagged protein localising to the plasma membrane in either the salivary gland primordium only (SrcGFP) or in all of the embryonic epithelium (ArmYFP). The isolated fluorescent cells were sent for single cell RNA sequencing to investigate the genetic programmes involved in early salivary gland tubulogenesis....”

Adaptive Informational Design of Confirmatory Phase III Trials With an Uncertain Biomarker Effect to Improve the Probability of Success nork Cong Chen (325493)

“...<p>Oncology drug developers sometimes decide to initiate Phase III randomized confirmatory trials at risk after significant preliminary anti-tumor activities are observed in small Phase I/II single arm studies. There are two clear challenges. First, these investigational drugs may have a greater benefit in a biomarker enriched population. ...”

Stimuli and protocols. nork Siobhan C. Dongés (3772564)

“...<p>In Studies 1 and 2, 20 min of real or sham cervical transcutaneous spinal direct current stimulation (tsDCS) was applied through saline soaked sponge electrodes placed anteriorly below the cervicomental angle, and posteriorly over the spinous process of C7. Real tsDCS involved an initial ramping-up of intensity over 30 s, followed by stimulation at 3 mA for the remainder of the 20 min, whereas sham tsDCS involved an initial ramping-up of intensity over 30 s, 1 min of stimulation at 3 mA, then no stimulation for the remainder of the 20 min. ...”

Predictions of Domains with Confident SCOP Superfamily Assignment Scores That Were Subsequently Solved nork Lars Malmström (5812)

“...</p> <p>(C) KAP104/YBR017C is involved in nuclear localization sequence binding and was predicted to belong to the ARM repeat (a.118.1) superfamily with <i>P</i>(SF|D,GO) = 0.99 (<i>P</i>_MCM = 0.8; MAMMOTH <i>Z</i>-score to homologous structure [31% sequence identity] was 4.41)....”

Data_Sheet_1_Proprioceptive Augmentation With Illusory Kinaesthetic Sensation in Stroke Patients Improves Movement Quality in an Active Upper Limb Reach-and-Point Task.pdf nork Francesca Ferrari (5018804)

“...To assess the impact of augmented kinaesthetic feedback on motor function we compared the results of vibrating the biceps or triceps during arm extension in the affected arm of stroke patients and able-bodied participants. ...”

Video_1_Proprioceptive Augmentation With Illusory Kinaesthetic Sensation in Stroke Patients Improves Movement Quality in an Active Upper Limb Reach-and-Point Task.MP4 nork Francesca Ferrari (5018804)

“...To assess the impact of augmented kinaesthetic feedback on motor function we compared the results of vibrating the biceps or triceps during arm extension in the affected arm of stroke patients and able-bodied participants. ...”

Schematic representation of 3- and 4-way junction families. nork Christian Laing (450238)

“...<p>(A) Three major family types – A, B, and C – are found in 3-way junctions where the helical arm, not involved in coaxial stacking, has different helical arrangements with respect to the coaxially stacked helices. ...”

Crystal structure of Mal-TIR. nork Zhijie Lin (173992)

“...<p>(<b>A</b>) Schematic illustration of five TIR-domain-containing adaptors involved in TLR signaling. Mal: MyD88 adaptor-like protein; MyD88: myeloid differentiation factor 88; TRIF: TIR-domain-containing adaptor-inducing interferon-β; TRAM: TRIF-related adaptor molecule; SARM: sterile and HEAT/armadillo (ARM) motif protein; DD: death domain; ID: intermediate domain; SAM: sterile α-motif. ...”

Antiviral defense systems drive persistence but limit the transfer of antimicrobial resistance genes in anaerobic digestion nork Junya Zhang (22228321)

“...Our findings elucidate the dual nature of ADS caused by phage-bacteria arm race in AMR dynamics, and offer a framework to harness phage lysis and ADS for global AMR mitigation across environmental systems....”

DataSheet1_Hypogravity modeling of upper extremities: an investigation of manual handling in the workplace.docx nork Tatiana Maillard (17078167)

“...Twenty-four healthy participants aged 33.6 ± 8.2 years were involved in the trial. Joint angles were examined using vision-based 3D motion analysis. ...”

Schematic representation of the domain assignments to hypothetical protein kinases encoded in the human genome nork A Krupa (55137)

“...The other domains are labeled as follows: ARMB, ARM repeats of β-catenin-like proteins; ARMH, HEAT-related ARM-repeats; eH, homologous regions found in proteins of eukaryotes (, , ); HH, homologous region found in human proteins; MH, homologous regions found in proteins of mammals (mouse and human); PDZ, a conserved domain in PSD95, DLG and ZO-1; PrH, homologous regions found in proteins of primates ( species and human); TM, transmembrane region. function unknown (ENSP207880); function unknown (ENSP252105); function unknown (gi13652558; homologs have been found only in eukaryotes); function unknown (ENSP250481; homologs have been found only in mouse); function unknown (ENSP234334); function unknown (ENSP232788); function unknown (ENSP188359); predicted BMP2-inducible kinase (ENSP251485); protein kinase involved in embryonic development (ENSP250887); protein kinase associated with the dystrophy complex (ENSP251197); protein kinase similar to mouse apoptosis-associated kinase (ENSP251707); protein kinase of unknown function (ENSP244847)....”

tRNAs Promote Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes nork Lyubov Zaitseva (274639)

“...Mutational analyses indicated that the anticodon loop mediated binding to the viral complex whereas the T-arm may interact with cellular factors involved in nuclear import. ...”

Selection strategies for identifying RNA-cleaving deoxyribozymes nork Scott K. Silverman (9710)

“...In strategy 2, the single ribonucleotide cleavage site was placed between two Watson–Crick binding arms, as first reported by Breaker and Joyce () and used in several subsequent experiments (,,,,). ...”

The Weak Shall Inherit: Bacteriocin-Mediated Interactions in Bacterial Populations nork Hadeel Majeed (413951)

“...<div><p>Background</p><p>Evolutionary arms race plays a major role in shaping biological diversity. ...”

Table_2_Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial.XLSX nork Christina Balle (3609722)

“...An integrated multivariate analysis demonstrated that networks of microbial dysbiosis and inflammation best discriminated the CCVR arm from the other contraceptive groups, while genes involved in epithelial cell differentiation were predictive of the Net-En and COC arms. ...”

Table_11_Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial.XLSX nork Christina Balle (3609722)

“...An integrated multivariate analysis demonstrated that networks of microbial dysbiosis and inflammation best discriminated the CCVR arm from the other contraceptive groups, while genes involved in epithelial cell differentiation were predictive of the Net-En and COC arms. ...”

Table_9_Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial.XLSX nork Christina Balle (3609722)

“...An integrated multivariate analysis demonstrated that networks of microbial dysbiosis and inflammation best discriminated the CCVR arm from the other contraceptive groups, while genes involved in epithelial cell differentiation were predictive of the Net-En and COC arms. ...”