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different gene » differential gene (Expand Search)
gene algorithm » genetic algorithm (Expand Search), deer algorithm (Expand Search), cosine algorithm (Expand Search)
different gene » differential gene (Expand Search)
gene algorithm » genetic algorithm (Expand Search), deer algorithm (Expand Search), cosine algorithm (Expand Search)
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Parallel genetic algorithm for disease-gene association
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A fast exact sequential algorithm for the partial digest problem
Published 2016“…Two types of simulated data, random and Zhang, are used to measure the efficiency of the algorithm. We also apply the algorithm to real data for the Luciferase gene and the <i>E. coli</i> K12 genome.…”
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Leveraging Machine and Deep Learning Algorithms for hERG Blocker Prediction
Published 2025“…<p dir="ltr">The human ether-a-go-go-related (hERG) gene is crucial in enabling the regulation of repolarisation process in the heart. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…<h3>Background</h3><p dir="ltr">Biological networks contribute effectively to unveil the complex structure of molecular interactions and to discover driver genes especially in cancer context. It can happen that due to gene mutations, as for example when cancer progresses, the gene expression network undergoes some amount of localized re-wiring. …”
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Assessment of network module identification across complex diseases
Published 2019“…<p dir="ltr">Many bioinformatics methods have been proposed for reducing the complexity of large gene or protein networks into relevant subnetworks or modules. …”
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Network-based identification of key master regulators associated with an immune-silent cancer phenotype
Published 2021“…We use a consensus of four different pipelines consisting of two state-of-the-art gene regulatory network inference techniques, regularized gradient boosting machines and ARACNE to determine TR regulons, and three separate enrichment techniques, including fast gene set enrichment analysis, gene set variation analysis and virtual inference of protein activity by enriched regulon analysis to identify the most important TRs affecting immunologic antitumor activity. …”
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Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19
Published 2020“…Interestingly, although macrophages were also present in healthy subjects and patients with mild COVID-19, they had different gene signatures, indicative of interstitial and cluster-0 macrophage (i.e., FABP4, APOC1, APOE, C1QB, and NURP1). …”
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Optimizing clopidogrel dose response
Published 2016“…The aim of the study is to investigate the cumulative effect of CYP2C19 gene polymorphisms and drug interactions that affects clopidogrel dosing, and apply it into a new clinical-pharmacogenetic algorithm that can be used by clinicians in optimizing clopidogrel-based treatment. …”
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Copy number variations in the genome of the Qatari population
Published 2015“…Up to 40 % of all CNVs affected genes, including novel CNVs affecting Mendelian disease genes, segregating at different frequencies in the 3 major Qatari subpopulations, including those with Bedouin, Persian/South Asian, and African ancestry. …”
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Comprehensive whole genome sequence analyses yields novel genetic and structural insights for Intellectual Disability
Published 2017“…We report results from a large secondary control study of 2081 exomes probing the pathogenicity of the above genes. We analyzed structural variation by four different algorithms including <i>de novo</i> genome assembly. …”
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Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics
Published 2024“…Hence, the current study focuses on the screening of clinically reported substitutions in the <i>RAF1</i> and <i>RAP1A</i> genes using predictive algorithms integrated with all‐atoms simulation, essential dynamics, and binding free energy methods. …”
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Enhanced climate change resilience on wheat anther morphology using optimized deep learning techniques
Published 2024“…The investigation also enhances our comprehension of the distinct roles played by various genes in abiotic stress tolerance among diverse wheat varieties. …”