Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α) de réir Armin Thalhammer (233088)

“…Some of these processes are centrally involved in regulation of cellular responses to hypoxia. …”

Video_6_Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.MP4 de réir Milvia Alata (8925635)

“…These white matter changes are progressive and can be involved in the clinical deterioration. Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) gives rise to a spectrum of clinical signs whose pathophysiology still needs to be understood.…”

DataSheet1_A new model for fatty acid hydroxylase-associated neurodegeneration reveals mitochondrial and autophagy abnormalities.docx de réir Frida Mandik (14255618)

“…The condition is caused by a homozygous or compound heterozygous mutation in fatty acid 2 hydroxylase (FA2H), whose encoded protein synthesizes 2-hydroxysphingolipids and 2-hydroxyglycosphingolipids and is therefore involved in sphingolipid metabolism. A few FAHN model organisms have already been established and give the first insight into symptomatic effects. …”

Data_Sheet_13_Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides.PDF de réir Ângela Brito (9090569)

“…This genome is the largest of the thirteen baeocyte-forming cyanobacterial genomes sequenced so far, and diverges from the most closely related strains. …”

Video_1_Longitudinal Evaluation of Cerebellar Signs of H-ABC Tubulinopathy in a Patient and in the taiep Model.MP4 de réir Milvia Alata (8925635)

“…These white matter changes are progressive and can be involved in the clinical deterioration. Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) gives rise to a spectrum of clinical signs whose pathophysiology still needs to be understood.…”

Data_Sheet_8_Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides.FASTA de réir Ângela Brito (9090569)

“…This genome is the largest of the thirteen baeocyte-forming cyanobacterial genomes sequenced so far, and diverges from the most closely related strains. …”

Table_2_Genetic Prioritization, Therapeutic Repositioning and Cross-Disease Comparisons Reveal Inflammatory Targets Tractable for Kidney Stone Disease.xlsx de réir Hai Fang (160549)

“…</p>Results<p>We generated an atlas of genetic target prioritization, with the top targets highly enriched for genes involved in the NF-kB regulation, including interaction neighbors of inflammasome genes. …”

Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity de réir Vibha Singh (3937961)

“…<p>The Tousled Like kinases (TLKs) are involved in numerous cellular functions, including the DNA Damage Response (DDR), but only a handful of substrates have been identified thus far. …”

Image_6_Phytochrome A Regulates Carbon Flux in Dark Grown Tomato Seedlings.JPEG de réir Keisha D. Carlson (298516)

“…Most phytochromes are activated by red light and de-activated by far-red light, but phytochrome A (phyA) is responsive to both and plays an important role during the well-studied transition of seedlings from dark to light growth. …”

Table_1_Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides.XLSX de réir Ângela Brito (9090569)

“…This genome is the largest of the thirteen baeocyte-forming cyanobacterial genomes sequenced so far, and diverges from the most closely related strains. …”

Table_6_Genetic Prioritization, Therapeutic Repositioning and Cross-Disease Comparisons Reveal Inflammatory Targets Tractable for Kidney Stone Disease.xlsx de réir Hai Fang (160549)

“…</p>Results<p>We generated an atlas of genetic target prioritization, with the top targets highly enriched for genes involved in the NF-kB regulation, including interaction neighbors of inflammasome genes. …”

Table_12_Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides.XLSX de réir Ângela Brito (9090569)

“…This genome is the largest of the thirteen baeocyte-forming cyanobacterial genomes sequenced so far, and diverges from the most closely related strains. …”

Receptor Tyrosine Kinase (RTK) Mediated Tyrosine Phosphor-Proteome from Drosophila S2 (ErbB1) Cells Reveals Novel Signaling Networks de réir Srinivasan Krishnamoorthy (52404)

“…Tyrosine phosphorylation events mediated by aberrant activation of Receptor Tyrosine Kinase (RTK) pathways have been proven to be involved in the development of several diseases including cancer. …”

Design and Pharmacological Characterization of α₄β₁ Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Anta... de réir Michele Anselmi (14852037)

“…α₄β₁ integrin is a cell adhesion receptor deeply involved in the migration and accumulation of leukocytes. …”

DataSheet1_Virtual Screening of Drug-Like Compounds as Potential Inhibitors of the Dengue Virus NS5 Protein.pdf de réir Leidy L. García-Ariza (12069737)

“…Annually, there are about 400 million new cases of dengue worldwide, and so far there is no specific treatment against this disease. …”

Prevalence of major virulence factors and resistance determinants in 317 SAB isolates. de réir Siegbert Rieg (445802)

“…Fusidic acid resistance (<i>far1</i>), surface protein involved in biofilm formation (<i>bap</i>) genes and capsule type 1 genes (capH1/I1/J1/K1) were not detected.…”

Table_3_Comparative Genomics Discloses the Uniqueness and the Biosynthetic Potential of the Marine Cyanobacterium Hyella patelloides.XLSX de réir Ângela Brito (9090569)

“…This genome is the largest of the thirteen baeocyte-forming cyanobacterial genomes sequenced so far, and diverges from the most closely related strains. …”

Design and Pharmacological Characterization of α₄β₁ Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Anta... de réir Michele Anselmi (14852037)

“…α₄β₁ integrin is a cell adhesion receptor deeply involved in the migration and accumulation of leukocytes. …”

Image_1_Complete Genome Assemblies of All Xanthomonas translucens Pathotype Strains Reveal Three Genetically Distinct Clades.PNG de réir Florian Goettelmann (12177245)

“…Further investigation of these genes could help to identify genes that are critically involved in pathogenicity and/or host adaptation, setting the grounds for the development of new resistant cultivars.…”

Data_Sheet_1_Complete Genome Assemblies of All Xanthomonas translucens Pathotype Strains Reveal Three Genetically Distinct Clades.FASTA de réir Florian Goettelmann (12177245)

“…Further investigation of these genes could help to identify genes that are critically involved in pathogenicity and/or host adaptation, setting the grounds for the development of new resistant cultivars.…”