Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1 por Dorota Niedzialek (1974655)

“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”

Data_Sheet_1_Co-infection of two eukaryotic pathogens within clam populations in Arcachon Bay.DOCX por Sarah Itoïz (8446872)

“…This ecological study demonstrates that the detection and quantification of both parasitic species, P. olseni and P. chesapeaki, is essential and timely in resolving cryptic infections and their consequences on individual hosts and clam populations.…”

Data from: Quantifying seed rain patterns in a remnant and a chronosequence of restored tallgrass prairies in north central Missouri por Katherine Wynne (22078346)

“…However, knowledge of seed rain patterns is limited to those observed in forests and late-assembling grasslands, which might not reflect early-assembling communities such as newly restored grasslands. Resolving this gap in our understanding provides further insight into the role of seed dispersal.…”

Data_Sheet_1_Prenatal Genetic Counseling in a Chinese Pregnant Woman With Rare Thalassemia: A Case Report.PDF por Liangying Zhong (5642819)

“…An intronic variant located far from obvious regulatory sequences in the HBB gene could be very difficult to evaluate as it may affect the mRNA processing or cause β-thalassemia (β-thal). …”

<i>D</i>₂-Symmetric Dimer of 1,1‘-Binaphthyl and Its Chiral π-Conjugated Carbodianion por Andrzej Rajca (1339899)

“…However, CD and UV spectra, and cyclic voltammetric data of (<i>R</i>)(+)-<b>3 </b>are consistent with small, but far from negligible, conjugation (or homoconjugation) between the naphthalene moieties. …”

Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1 por Dorota Niedzialek (1974655)

“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”

Data_Sheet_2_Co-infection of two eukaryotic pathogens within clam populations in Arcachon Bay.DOCX por Sarah Itoïz (8446872)

“…This ecological study demonstrates that the detection and quantification of both parasitic species, P. olseni and P. chesapeaki, is essential and timely in resolving cryptic infections and their consequences on individual hosts and clam populations.…”

<i>Superstesaster promissor</i> gen. et sp. nov., a new starfish (Echinodermata, Asteroidea) from the Early Triassic of Utah, USA, filling a major gap in the phylogeny of asteroids por Loïc Villier (3933644)

“…Including 30 species and 70 morphological characters, it is the most comprehensive phylogeny produced for fossil starfishes so far. Relationships among Palaeozoic forms remain poorly resolved, but their position in the tree is grossly consistent with stratigraphy. …”

Plk2 interacts with NPM/B23 <i>in vivo</i> and <i>in vitro</i>. por Annekatrin Krause (365995)

“…IgG, random antibody control. <b>D</b> Far Western blot analysis. Recombinant His-tagged NPM/B23 was resolved by SDS-PAGE, blotted onto nitrocellulose and incubated with GST-Plk2 PBD, -PBD mutant or GST (control) to allow interaction. …”

Large Ground-State and Excited-State Crystal Field Splitting of 8-fold-Coordinate Cm³⁺ in [Y(H₂O)₈]Cl₃·15-crown-5 por Patric Lindqvist-Reis (2132083)

“…The transitions between the ground state and the respective lowest crystal-field levels of the excited states exhibit narrow fluorescence lines, resolving the four crystal-field levels of the ground state as sharp, well-resolved lines at about 0, 10, 19, and 35 cm^-1. …”

How I joined the Intelligence Corps por Their Finest Hour Project Team (18604667)

“…</p><p>I was made a Guard Runner, which involved me standing at the main entrance gate with a large stick held behind my back and when a visitor came to the gate I would be assigned to take the visitor to the required destination and another Guard Runner would take my place. …”

Data_Sheet_1_The Effect of Magnesium on Reperfusion Arrhythmias in STEMI Patients, Treated With PPCI. A Systematic Review With a Meta-Analysis and Trial Sequential Analysis.PDF por Laszlo B. Szapary (9966656)

“…A statistical analysis was performed on three randomized-controlled trials using three common parameters, involving 336 patients Trial sequential analysis (TSA) was applied to assess the risk of random error associated with sparse data and multiple testing which can affect cumulative meta-analysis. …”

Table_1_The Synaptic Gene Study: Design and Methodology to Identify Neurocognitive Markers in Phelan-McDermid Syndrome and NRXN1 Deletions.DOCX por Jennifer Cooke (2523625)

“…<p>Synaptic gene conditions, i.e., “synaptopathies,” involve disruption to genes expressed at the synapse and account for between 0.5 and 2% of autism cases. …”

Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson’s Disease: A Short-Term Regional Homogeneity fMRI Study por Zhi Wen (458994)

“…The neural basis underlying thalamotomy is complex; cerebellum involvement is far beyond cerebello-thalamic tract breakage.…”

Structural and Photoluminescence Studies of a Europium(III) Tetrakis(β-diketonate) Complex with Tetrabutylammonium, Imidazolium, Pyridinium and Silica-Supported Imidazolium Counter... por Sofia M. Bruno (2166229)

“…Besides electrostatic interactions, the crystal packing in all three structures is stabilized by offset π−π interactions involving the naphthyl rings of neighboring complexes (and, for [C₄mim][Eu(NTA)₄] and [C₄mpyr][Gd(NTA)₄], neighboring naphthyl/imidazolium and naphthyl/pyridinium rings) and C−H···π contacts. …”

Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study por Jose Xavier-Neto (3775303)

“…The model utilizes immunocompetent animals from wild-type FVB/NJ and C57BL/6J strains, providing a better analogy to the human condition than approaches involving immunodeficient, genetically modified animals, or direct ZIKV injection into the brain. …”

Mechanistic Studies on the Catalytic Synthesis of BN Heterocycles (1<i>H</i>‑2,1-Benzazaboroles) at Ruthenium por Marion Beguerie (4735842)

“…Prospects on reactions involving at least two different intramolecular reactive functions should be encouraged for future development in catalysis.…”

Image_1_Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease.TIF por Yu Ding (54012)

“…</p><p>Methods: An unbiased approach using far western ligand blots has identified three synaptic proteins to which AβOs specifically attach. …”

DataSheet_1_Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis.pdf por Michał Rudnik (11322828)

“…Animal studies pointed to bone marrow-derived cells as a potential source of pathological ECM-producing cells in immunofibrotic disorders. So far, involvement of monocytes and macrophages in the fibrogenesis of SSc remains poorly understood.…”

Datasheet1_Use of implementation science to advance family planning programs in low- and middle-income countries: A systematic review.pdf por Colin Baynes (7527287)

“…Fourteen percent of studies described measures to involve stakeholders in the research process. Only 7 percent of studies reported that implementation was led by LMIC delivery systems or implementation partners.…”