Image_1_Notch1 and Galectin-3 Modulate Cortical Reactive Astrocyte Response After Brain Injury.TIF od Tais Novaki Ribeiro (10977453)

“…In this context, we addressed the role of Notch1 signaling and the effect of Galectin-3 (Gal3) as underlying molecular candidates involved in cortical astrocyte response to injury. …”

Serum after Autologous Transplantation Stimulates Proliferation and Expansion of Human Hematopoietic Progenitor Cells od Thomas Walenda (227183)

“…In this study, we have addressed the question if systemically released factors are involved in activation of hematopoietic stem and progenitor cells (HPC) after autologous HSCT. …”

DataSheet1_Genome-wide Identification and Analysis of Splicing QTLs in Multiple Sclerosis by RNA-Seq Data.docx od Yijie He (6882242)

“…The retained intron AS events are more susceptible to influence of genome variants, and their functions are involved in protein kinase and phosphorylation modification. …”

Table_3_Comparative Genomics of Potato Common Scab-Causing Streptomyces spp. Displaying Varying Virulence.xlsx od figshare admin frontiersin (4545187)

“…Their phylogenomic affiliation was determined, their pan-genome was characterized, and pathogenic determinants involved in their virulence, ranging from weak to aggressive, were compared. 13 out of 14 strains clustered with Streptomyces scabiei, while the last strain clustered with Streptomyces acidiscabies. …”

Transcriptomic insights into essential oil biosynthesis in coriander (<i>Coriandrum sativum</i> L.) od Sharda Choudhary (20792954)

“…Myrcene synthase was specifically found in Pant Haritma seeds. Furthermore, genes involved in the metabolism of vitamins such as thiamine, riboflavin, and vitamin B6 have been identified, along with medicinally and nutritionally significant metabolites. …”

DataSheet_1_Harnessing monocrop breeding strategies for intercrops.zip od Reena Dubey (17778594)

“…We show that the optimal stage for switching from monocrop to intercrop testing should be adapted to the specificity of the crop and the heritability of the traits involved. However, the genetic correlation between the monocrop and intercrop trait performance is the primary driver of the intercrop breeding scheme optimization process.…”

Efficient Construction of Homozygous Diploid Strains Identifies Genes Required for the Hyper-Filamentous Phenotype in <em>Saccharomyces cerevisiae</em> od Kentaro Furukawa (199753)

“…Those include well-known positive regulator genes for filamentous growth signaling pathways, genes involved in mitochondrial function, DNA damage checkpoint, chromatin remodeling, and cell cycle, and also previously uncharacterized genes. …”

The Effects of Extra-Somatic Weapons on the Evolution of Human Cooperation towards Non-Kin od Tim Phillips (559406)

“…Widespread weapons use could have made disputes within hominin groups far more lethal and also equalized power between individuals. …”

Table 3_Assessment of the effects of cannabidiol and a CBD-rich hemp extract in Caenorhabditis elegans.docx od Jessica A. Camacho (19769295)

“…Multiple pathways and signaling cascades involved in organismal development and neuronal function, including endocannabinoid synthesis and signaling systems, are well conserved across phyla, suggesting that Caenorhabditis elegans can model the in vivo effects of exogenous cannabinoids. …”

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia od Nagore I. Marín-Ramos (1600555)

“…In this work we report a potent ICMT inhibitor, compound <b>3</b> [UCM-1336, IC₅₀ = 2 μM], which is selective against the other enzymes involved in the post-translational modifications of Ras. …”

Table4_Functional analysis of differently expressed ferroptosis-related genes in patients with mitral valve prolapse.XLSX od Hui Xie (195238)

“…Notably, these genes are primarily involved in the extracellular region and p53 signaling pathway.…”

Table_2_Integrated Microbiome and Metabolome Analysis Reveals a Positive Change in the Intestinal Environment of Myostatin Edited Large White Pigs.pdf od Yangli Pei (727447)

“…While both genotype and microbial composition are known to affect the host phenotype, so far there has been no systematic study to detect the changes in the intestinal microbial composition and metabolome of MSTN single copy mutant pigs. …”

Table_1_Comparative Genomics of Potato Common Scab-Causing Streptomyces spp. Displaying Varying Virulence.DOCX od Cindy Hudec (5527016)

“…Their phylogenomic affiliation was determined, their pan-genome was characterized, and pathogenic determinants involved in their virulence, ranging from weak to aggressive, were compared. 13 out of 14 strains clustered with Streptomyces scabiei, while the last strain clustered with Streptomyces acidiscabies. …”

Image_6_A Chinese White Pear (Pyrus bretschneideri) BZR Gene PbBZR1 Act as a Transcriptional Repressor of Lignin Biosynthetic Genes in Fruits.tif od Yunpeng Cao (3609377)

“…Our study traces the evolution of BZR gene family members in Rosaceae genomes and illustrates that the rates of gene loss and gain are far from equilibrium in different species. At the same time, our results suggest that PbBZR1 may be involved in the negative regulation of lignin biosynthesis.…”

Image_1_A Chinese White Pear (Pyrus bretschneideri) BZR Gene PbBZR1 Act as a Transcriptional Repressor of Lignin Biosynthetic Genes in Fruits.tif od Yunpeng Cao (3609377)

“…Our study traces the evolution of BZR gene family members in Rosaceae genomes and illustrates that the rates of gene loss and gain are far from equilibrium in different species. At the same time, our results suggest that PbBZR1 may be involved in the negative regulation of lignin biosynthesis.…”

Functional autoantibodies in patients with different forms of dementia od Gerd Wallukat (252625)

“…<div><p>Dementia in general and Alzheimer’s disease in particular is increasingly seen in association with autoimmunity being causatively or supportively involved in the pathogenesis. Besides classic autoantibodies (AABs) present in dementia patients, there is the new autoantibody class called functional autoantibodies, which is directed against G-protein coupled receptors (GPCRs; GPCR-AABs) and are seen as pathogenic players. …”

The Effect of Temperature on the Proteome of Recombinant <i>Pichia pastoris</i> od Martin Dragosits (2388358)

“…The impact of environmental factors on the productivity of yeast cells is poorly investigated so far. Therefore, it is a major concern to improve the understanding of cellular physiology of microbial protein production hosts, including the methylotrophic yeast <i>Pichia pastoris.…”

Video_1_Reconstruction of Intratelencephalic Neurons in the Mouse Secondary Motor Cortex Reveals the Diverse Projection Patterns of Single Neurons.MPG od Hui-Min Lin (3455366)

“…We obtained a neuron with an axonal length of 318.43 mm, which is by far the longest reported axonal length. Our results show that all individual neurons in the MOs, regardless of whether they are located in layer 2/3 or layer 5, display diverse projection patterns and projection strengths, implying that these neurons might be involved in different brain circuits at different intensities. …”

Myosin Vb Mediated Plasma Membrane Homeostasis Regulates Peridermal Cell Size and Maintains Tissue Homeostasis in the Zebrafish Epidermis od Sonal (631310)

“…We have used genetic analysis in combination with cellular imaging to show that zebrafish <i>goosepimples/myosin Vb</i> regulates plasma membrane homeostasis and is involved in maintenance of cell size in the periderm, the outermost epidermal layer. …”

Hydrogen Tunneling above Room Temperature Evidenced by Infrared Ion Spectroscopy od Mathias Schäfer (1694968)

“…While hydrogen tunneling at elevated temperatures has, for instance, often been postulated in biochemical processes, spectroscopic proof is thus far limited to cryogenic conditions, under which thermal reactivity is negligible. …”