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141
Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1
Vydáno 2025“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”
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142
Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1
Vydáno 2025“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”
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143
Public opinions of Biodiversity Net Gain in England
Vydáno 2025“…</li><li>To what extent do the public trust the organisations involved in BNG?</li><li>What is the public’s opinion of BNG as an approach? …”
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144
Supplementary Material for: Plant Extracts in Acne Management: a narrative review
Vydáno 2025“…Acne pathophysiology is complex, involving altered sebum production and composition, abnormal keratinization, microbiome dysbiosis, and skin inflammation. …”
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145
A Method for Rapid and Precise Triple Oxygen Isotope Measurements via High-Temperature Conversion to CO Followed by Nickel-Catalyzed CO to CO<sub>2</sub> Conversion and Laser Spect...
Vydáno 2025“…We present a new method for high-precision Δ′<sup>17</sup>O analysis of CO<sub>2</sub> via tunable infrared laser direct absorption spectroscopy that is compatible with a wider range of geochemically important materials. This approach involves converting sample oxygen to CO<sub>2</sub> in two steps. …”
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146
A Method for Rapid and Precise Triple Oxygen Isotope Measurements via High-Temperature Conversion to CO Followed by Nickel-Catalyzed CO to CO<sub>2</sub> Conversion and Laser Spect...
Vydáno 2025“…We present a new method for high-precision Δ′<sup>17</sup>O analysis of CO<sub>2</sub> via tunable infrared laser direct absorption spectroscopy that is compatible with a wider range of geochemically important materials. This approach involves converting sample oxygen to CO<sub>2</sub> in two steps. …”
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147
Data Sheet 1_An fMRI study of crossmodal emotional congruency and the role of semantic content in the aesthetic appreciation of naturalistic art.pdf
Vydáno 2025“…<p>Numerous studies have explored crossmodal correspondences, yet have so far lacked insight into how crossmodal correspondences influence audiovisual emotional integration and aesthetic beauty. …”
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148
Supplementary Material for: Functional divergence between the Z and W alleles of the UBAP2 gene revealed by differences in their expression patterns in Japanese quail
Vydáno 2025“…We propose that UBAP2W contributes to ovarian development and oogenesis through the ubiquitin–proteasome pathway, while UBAP2Z is involved in general cellular regulation across sexes. …”
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149
DNA methylation-predicted protein differences between Yakutian and Central Russian populations
Vydáno 2025“…We found differences in 25 estimated protein levels between the two groups. These proteins are involved in important processes like managing energy use. …”
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150
Data Sheet 1_Food environment with high plant-based fat supply is associated with Attention-Deficit/Hyperactivity Disorder (ADHD) protection: a global study with more than 150 coun...
Vydáno 2025“…While its aetiology is unclear, it appears to involve a combination of genetic and environmental factors, particularly food environments including diets and nutrients. …”
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151
Data Sheet 1_Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with extracorporeal photopheresis.docx
Vydáno 2025“…It is characterized by a complex and heterogeneous profile of genetic alteration ns that has so far precluded the development of a specific and definitive therapeutic intervention.…”
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152
Evolution in the granularity of regulatory control networks in a subset of 100 competing models describing protein abundance profiles in subjects representative of low and high exa...
Vydáno 2025“…The least consistent predictions involve possible reciprocal co-regulation of TGM3 (Q08188) and TGOLN2 (Q43493)(relationship 35), so far undocumented.…”
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153
RAPID DETECTION OF HUMAN PAPILLOMAVIRUS (HPV) USING GOLD-SILVER NANOPARTICLE
Vydáno 2025“…<p dir="ltr">EP 3 510 410 B1</p><p><br></p><p dir="ltr">Description</p><p><br></p><p dir="ltr">FIELD OF THE INVENTION</p><p><br></p><p dir="ltr">[0001] The human papillomavirus (HPV) is one of the major factors involved in the development of various types of cancers, particularly cervical cancer. …”
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154
The Gut Microbiome's Influence on Extra- Intestinal Diseases: A Cross-Sectional Analysis of Neurological and Autoimmune Disorders
Vydáno 2025“…<p dir="ltr">The human gut microbiome, composed of trillions of microorganisms, plays a pivotal role in maintaining health and influencing disease processes far beyond the gastrointestinal tract. Disruptions in microbial balance, known as dysbiosis, have been increasingly associated with neurological and autoimmune conditions through complex interactions involving microbial metabolites, immune modulation, and neural pathways. …”
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155
DATA SET ICOBAR 2025.docx
Vydáno 2025“…A qualitative descriptive method was used, involving semi-structured interviews with key informants from the Ministry of Energy and Mineral Resources. …”
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156
Jerome’s Sources in His Translation of the Hebrew Bible (PDF)
Vydáno 2025“…In this volume, Paul Rodrigue investigates the sources that Jerome may have drawn upon in the process of translation. Far from being just a rendering of the Hebrew-Aramaic Bible, the Vulgate emerges as a layered and multifaceted translation, shaped not only by the Hebrew-Aramaic text but also by a broad array of additional sources. …”
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157
Demographics.
Vydáno 2025“…<div><p>Research on moral injury has thus far paid little attention to social factors and cultural elements. …”
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158
Themes qualitative interviews.
Vydáno 2025“…<div><p>Research on moral injury has thus far paid little attention to social factors and cultural elements. …”
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159
Scenario 2: firefight.
Vydáno 2025“…<div><p>Research on moral injury has thus far paid little attention to social factors and cultural elements. …”
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160
Video 1_Downbeat nystagmus in association with the dorsal midbrain syndrome: proposed mechanisms, literature review, and case series.mov
Vydáno 2025“…Introduction<p>Downbeat nystagmus (DBN) is classically attributed to cerebellar pathology. Far less often, DBN arises from brainstem disease, with midbrain etiologies being exceptionally rare and poorly characterized. …”