Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition מאת Antonio Macchiarulo (182335)

"...MDM2 and MDMX are oncogenic homologue proteins that regulate the activity and stability of p53, a tumor suppressor protein involved in more than 50% of human cancers. While the large body of experiments so far accumulated has validated MDM2 as a therapeutically important target for the development of anticancer drugs, it is only recently that MDMX has also become an attractive target for the treatment of tumor cells expressing wild type p53. ..."

The secretin-pilotin complex. מאת Shuang Gu (184317)

"...(E) Close up showing the hydrophobic nature of the complementary side chains involved in forming the complex.</p>..."

Table_1_Epilithic Microbial Community Functionality in Deep Oligotrophic Continental Bedrock.XLSX מאת Maija Nuppunen-Puputti (12162836)

"...<p>The deep terrestrial biosphere hosts vast sessile rock surface communities and biofilms, but thus far, mostly planktic communities have been studied. ..."

Table_2_Quorum Sensing-Mediated and Growth Phase-Dependent Regulation of Metabolic Pathways in Hafnia alvei H4.XLS מאת Congyang Yan (10215572)

"...<p>Quorum sensing (QS) is a widespread regulatory mechanism in bacteria used to coordinate target gene expression with cell density. Thus far, little is known about the regulatory relationship between QS and cell density in terms of metabolic pathways in Hafnia alvei H4. ..."

Therapeutic Assessment of Vulvar Squamous Intraepithelial Lesions with CO2 Laser Vaporization in Immunosuppressed Patients מאת Julisa Chamorro Lascasas Ribalta (5313029)

"...Results Patients bearing vulvar high-grade squamous intraepithelial lesion and immunosuppressed (serumpositive forhumanimmunodeficiency virus [HIV] or with solid organs transplantation) have shown a higher level of persistence of lesions and a higher chance of having other areas of the female lower genital tract involved. Conclusion While the CO2 laser vaporization is the most conservative method for the treatment of vulvar high-grade intraepithelial lesions, it is far frombeing the ideal method, dueto the intrinsic infection features considered. ..."

Data_Sheet_1_BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo.docx מאת Wibke Singer (306957)

"...<p>Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. ..."

Table1.XLSX מאת Jing Hou (18672)

"...<p>Galaxea fascicularis, a stony coral belonging to family Oculinidae, is widely distributed in Red Sea, the Gulf of Aden and large areas of the Indo-Pacific oceans. So far there is a lack of gene expression knowledge concerning this massive coral. ..."

Image_4_An ex vivo Approach to Study Hormonal Control of Spermatogenesis in the Teleost Oreochromis niloticus.TIF מאת Michelle Thönnes (9109367)

"...The pituitary gonadotropins, luteinizing hormone, and follicle stimulating hormone, are indispensable for vertebrate spermatogenesis, but we are still far from fully understanding the complex regulatory networks involved in this process. ..."

<i>Meioc</i> maintains an extended meiotic prophase I in mice מאת Y. Q. Shirleen Soh (611074)

"...Mouse germ cells lacking <i>Meioc</i> initiate meiosis: they undergo pre-meiotic DNA replication, they express proteins involved in synapsis and recombination, and a subset of cells progress as far as the zygotene stage of prophase I. ..."

Image_1_Proteomic Identification of Pathways Responsible for the Estradiol Therapeutic Window in AD Animal Models.TIFF מאת Jie Cui (198388)

"...Our results showed that different signaling pathways were involved in the regulatory effects of estradiol on MAP1A and hemoglobin α. ..."

Identification of New Mechanisms of Cellular Response to Chemotherapy by Tracking Changes in Post-Translational Modifications by Ubiquitin and Ubiquitin-Like Proteins מאת Thomas Bonacci (514801)

"...Gemcitabine treatment altered the PTM profile of proteins involved in various biological functions, some known cancer associated genes, many potentially cancer-associated genes, and several cancer-signaling networks, including canonical and noncanonical WNT and PI3K/Akt/MTOR pathways. ..."

Image_8_An ex vivo Approach to Study Hormonal Control of Spermatogenesis in the Teleost Oreochromis niloticus.TIF מאת Michelle Thönnes (9109367)

"...The pituitary gonadotropins, luteinizing hormone, and follicle stimulating hormone, are indispensable for vertebrate spermatogenesis, but we are still far from fully understanding the complex regulatory networks involved in this process. ..."

Supplementary Material for: Primary ovarian failure in addition to classical clinical features of Coats Plus Syndrome in a female carrying two truncating variants of CTC1 מאת Riquelme J. (11612020)

"...Coats plus syndrome is an autosomal recessive multisystemic and pleiotropic disorder affecting the eyes, brain, bone, and gastrointestinal tract, usually caused by compound heterozygous variants of the Conserved Telomere maintenance Component 1 gene (CTC1), involved in telomere homeostasis and replication. So far, most reported patients are compound heterozygous for a truncating mutation and a missense variant. ..."

Taking Root: Enduring Effect of Rhizosphere Bacterial Colonization in Mangroves מאת Newton C. M. Gomes (188736)

"...Due to the sheer abundance of roots in mangrove habitat, such an effect can have an important impact on the maintenance of bacterial guilds involved in nutrient cycling and other key ecosystem functions. ..."

Cell Surface Proteome Analysis of Human-Hosted <i>Trypanosoma cruzi</i> Life Stages מאת Rayner M. L. Queiroz (570219)

"...</i> It remains a challenging health issue in Latin America, where it is endemic, and so far there is no immunoprophylatic vaccine or satisfactory chemotherapic treatment for its chronic stage. ..."

Table_2_An ex vivo Approach to Study Hormonal Control of Spermatogenesis in the Teleost Oreochromis niloticus.docx מאת Michelle Thönnes (9109367)

"...The pituitary gonadotropins, luteinizing hormone, and follicle stimulating hormone, are indispensable for vertebrate spermatogenesis, but we are still far from fully understanding the complex regulatory networks involved in this process. ..."

Public opinions of Biodiversity Net Gain in England מאת Alice Stuart (13046145)

"...</li><li>To what extent do the public trust the organisations involved in BNG?</li><li>What is the public’s opinion of BNG as an approach? ..."

Table_3_A Chinese White Pear (Pyrus bretschneideri) BZR Gene PbBZR1 Act as a Transcriptional Repressor of Lignin Biosynthetic Genes in Fruits.xlsx מאת Yunpeng Cao (3609377)

"...Our study traces the evolution of BZR gene family members in Rosaceae genomes and illustrates that the rates of gene loss and gain are far from equilibrium in different species. At the same time, our results suggest that PbBZR1 may be involved in the negative regulation of lignin biosynthesis...."

Table_1_Altered cerebellar functional connectivity in chronic subcortical stroke patients.DOCX מאת Wenjun Hong (14103528)

"...Background<p>Previous studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. ..."

Table_5_Comparative Genomics of Potato Common Scab-Causing Streptomyces spp. Displaying Varying Virulence.DOCX מאת Cindy Hudec (5527016)

"...Their phylogenomic affiliation was determined, their pan-genome was characterized, and pathogenic determinants involved in their virulence, ranging from weak to aggressive, were compared. 13 out of 14 strains clustered with Streptomyces scabiei, while the last strain clustered with Streptomyces acidiscabies. ..."