Unveiling Current Guanaco Distribution in Chile Based upon Niche Structure of Phylogeographic Lineages: Andean Puna to Subpolar Forests por Benito A. González (393011)

“…Here we model the environmental niche structure and distribution of the recently resolved phylogeography of guanaco (<i>Lama guanicoe</i>) lineages on the western slope of the southern Andes. …”

Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1 por Dorota Niedzialek (1974655)

“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”

Image_2_Allocation of Interferon Gamma mRNA Positive Cells in Caecum Hallmarks a Protective Trait Against Histomonosis.JPEG por Fana Alem Kidane (5296946)

“…The protective mechanisms that underpin the vaccine-induced immune response are not resolved so far. Therefore, the actual study aimed to evaluate the location and quantitative distribution patterns of signature cytokines of type 1 [interferon gamma (IFN-γ)] or type 2 [interleukin (IL)-13] immune responses in vaccinated or infected hosts. …”

Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1 por Dorota Niedzialek (1974655)

“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”

Data_Sheet_1_Co-infection of two eukaryotic pathogens within clam populations in Arcachon Bay.DOCX por Sarah Itoïz (8446872)

“…This ecological study demonstrates that the detection and quantification of both parasitic species, P. olseni and P. chesapeaki, is essential and timely in resolving cryptic infections and their consequences on individual hosts and clam populations.…”

Data from: Quantifying seed rain patterns in a remnant and a chronosequence of restored tallgrass prairies in north central Missouri por Katherine Wynne (22078346)

“…However, knowledge of seed rain patterns is limited to those observed in forests and late-assembling grasslands, which might not reflect early-assembling communities such as newly restored grasslands. Resolving this gap in our understanding provides further insight into the role of seed dispersal.…”

Data_Sheet_1_Prenatal Genetic Counseling in a Chinese Pregnant Woman With Rare Thalassemia: A Case Report.PDF por Liangying Zhong (5642819)

“…An intronic variant located far from obvious regulatory sequences in the HBB gene could be very difficult to evaluate as it may affect the mRNA processing or cause β-thalassemia (β-thal). …”

<i>D</i>₂-Symmetric Dimer of 1,1‘-Binaphthyl and Its Chiral π-Conjugated Carbodianion por Andrzej Rajca (1339899)

“…However, CD and UV spectra, and cyclic voltammetric data of (<i>R</i>)(+)-<b>3 </b>are consistent with small, but far from negligible, conjugation (or homoconjugation) between the naphthalene moieties. …”

Elucidation of the Catalytic Apparatus and Mechanism of Human Chitotriosidase‑1 por Dorota Niedzialek (1974655)

“…Finally, we demonstrated that binding of the first-in-class inhibitor OATD-01 induces subtle yet far-reaching dynamical changes within the active site, leading to dissociation of the immunoglobulin-like heterodimer and disruption of interactions with biological partners implicated in disease pathogenesis. …”

Data_Sheet_2_Co-infection of two eukaryotic pathogens within clam populations in Arcachon Bay.DOCX por Sarah Itoïz (8446872)

“…This ecological study demonstrates that the detection and quantification of both parasitic species, P. olseni and P. chesapeaki, is essential and timely in resolving cryptic infections and their consequences on individual hosts and clam populations.…”

<i>Superstesaster promissor</i> gen. et sp. nov., a new starfish (Echinodermata, Asteroidea) from the Early Triassic of Utah, USA, filling a major gap in the phylogeny of asteroids por Loïc Villier (3933644)

“…Including 30 species and 70 morphological characters, it is the most comprehensive phylogeny produced for fossil starfishes so far. Relationships among Palaeozoic forms remain poorly resolved, but their position in the tree is grossly consistent with stratigraphy. …”

Plk2 interacts with NPM/B23 <i>in vivo</i> and <i>in vitro</i>. por Annekatrin Krause (365995)

“…IgG, random antibody control. <b>D</b> Far Western blot analysis. Recombinant His-tagged NPM/B23 was resolved by SDS-PAGE, blotted onto nitrocellulose and incubated with GST-Plk2 PBD, -PBD mutant or GST (control) to allow interaction. …”

Large Ground-State and Excited-State Crystal Field Splitting of 8-fold-Coordinate Cm³⁺ in [Y(H₂O)₈]Cl₃·15-crown-5 por Patric Lindqvist-Reis (2132083)

“…The transitions between the ground state and the respective lowest crystal-field levels of the excited states exhibit narrow fluorescence lines, resolving the four crystal-field levels of the ground state as sharp, well-resolved lines at about 0, 10, 19, and 35 cm^-1. …”

Understanding Activity Trends in Electrochemical Dinitrogen Oxidation over Transition Metal Oxides por Samuel A. Olusegun (20022836)

“…Using density functional theory (DFT) calculations, we explore three possible N2OR mechanisms: direct adsorption and dissociative adsorption of N₂, and a Mars-van Krevelen (MvK)-type mechanism involving the adsorption of N₂ on a surface-bound atomic oxygen. …”

Table_1_Identification of a cytokine profile in serum and cerebrospinal fluid of pediatric and adult spinal muscular atrophy patients and its modulation upon nusinersen treatment.d... por Silvia Bonanno (3079938)

“…Defective immune organs have been found in preclinical models of SMA, suggesting an involvement of the immune system in the disease. However, the immune state in SMA patients has not been investigated so far. …”

Table_3_Mitochondrial Adaptations in Elderly and Young Men Skeletal Muscle Following 2 Weeks of Bed Rest and Rehabilitation.XLSX por Alessia Buso (6653861)

“…Based on quantitative immunoblot analyses, in both groups a reduction of two key regulators of mitochondrial biogenesis/remodeling and activity, namely PGC-1α and Sirt3, was revealed during bed-rest, with a subsequent up-regulation after rehabilitation, indicating an involvement of PGC-1α-Sirt3 axis in response to the treatments. …”

Table_1_CYP17A1–ATP2B1 SNPs and Gene–Gene and Gene–Environment Interactions on Essential Hypertension.xlsx por Bi-Liu Wei (7538519)

“…Two best significant two-locus models were screened out by GMDR software involving SNP–environment (rs11191548 and BMI ≥ 24 kg/m²) and haplotype–environment (CYP17A1 rs1004467G-rs11191548C and BMI ≥ 24 kg/m²) interactions (p ≤ 0.01). …”

Table_1_Mitochondrial Adaptations in Elderly and Young Men Skeletal Muscle Following 2 Weeks of Bed Rest and Rehabilitation.XLSX por Alessia Buso (6653861)

“…Based on quantitative immunoblot analyses, in both groups a reduction of two key regulators of mitochondrial biogenesis/remodeling and activity, namely PGC-1α and Sirt3, was revealed during bed-rest, with a subsequent up-regulation after rehabilitation, indicating an involvement of PGC-1α-Sirt3 axis in response to the treatments. …”

Image1_Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors.PDF por Dun Liu (674970)

“…Objective<p>Complex chromosome rearrangements (CCR) are rare structural abnormalities involving at least three breakpoints, categorized into three types based on their structure: type A (three-way rearrangements), type B (double two-way translocations), and type C (exceptional CCR). …”

Table_1_Assessing Collaboration in a National Research Partnership in Quality Improvement in Indigenous Primary Health Care: A Network Approach.DOCX por Frances C. Cunningham (5445470)

“…Partners' contribution of resources reflected their active involvement. There was a high level of agreement on the achievement of the key goals of the Partnership, showing shared sense-making amongst partners. …”