Plasmid map. 由 Jeremy Garb (18405156)

“...<div><p>Sterile alpha and TIR motif-containing 1 (SARM1) is a protein involved in programmed death of injured axons. Following axon injury or a drug-induced insult, the TIR domain of SARM1 degrades the essential molecule nicotinamide adenine dinucleotide (NAD⁺), leading to a form of axonal death called Wallerian degeneration. ...”

Plasmid map. 由 Jeremy Garb (18405156)

“...<div><p>Sterile alpha and TIR motif-containing 1 (SARM1) is a protein involved in programmed death of injured axons. Following axon injury or a drug-induced insult, the TIR domain of SARM1 degrades the essential molecule nicotinamide adenine dinucleotide (NAD⁺), leading to a form of axonal death called Wallerian degeneration. ...”

STROBE flow diagram of the included patients. 由 Michaela Krivošová (19507823)

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Characteristics of the patients. 由 Michaela Krivošová (19507823)

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ppat.1012111.t001 - Impaired upper respiratory tract barrier function during postnatal development predisposes to invasive pneumococcal disease 由 Kristen L. Lokken-Toyli (9455263)

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S3 Fig - 由 Kristen L. Lokken-Toyli (9455263)

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Neutrophil-mediated inflammation does not correlate with <i>Spn</i> dissemination. 由 Kristen L. Lokken-Toyli (9455263)

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Source data for supplemental figure graphs in this study. 由 Kristen L. Lokken-Toyli (9455263)

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Susceptibility to IPD is independent of pneumolysin. 由 Kristen L. Lokken-Toyli (9455263)

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Age-associated disruption in URT barrier function. 由 Kristen L. Lokken-Toyli (9455263)

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Factors contributing to invasive infection during early life. 由 Kristen L. Lokken-Toyli (9455263)

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Significant correlation between cytokine levels and BMI of patients in Day 1. 由 Michaela Krivošová (19507823)

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Decreased <i>Spn</i> proximity to the nasal epithelium with age. 由 Kristen L. Lokken-Toyli (9455263)

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S4 Fig - 由 Kristen L. Lokken-Toyli (9455263)

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Source data for main figure graphs in this study. 由 Kristen L. Lokken-Toyli (9455263)

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Cytokine levels in patients with active pulmonary TB at admission (Day 1) compared to healthy controls. 由 Michaela Krivošová (19507823)

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S1 Fig - 由 Kristen L. Lokken-Toyli (9455263)

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S1 Dataset - 由 Michaela Krivošová (19507823)

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Population bottleneck limits <i>Spn</i> translocation from the URT in infant mice. 由 Kristen L. Lokken-Toyli (9455263)

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Increased rate of IPD during early life is independent of systemic control and dependent on <i>Spn</i> translocation across the URT barrier. 由 Kristen L. Lokken-Toyli (9455263)

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