Image_1_Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis.jpeg מאת Selma Olsson Åkefeldt (11982299)

"...Finally, these preclinical data support that targeting both Mcl-1 and BCL2A1 with low-dose vinblastine and anti-IL-17A biotherapy may represent a synergistic combination for managing recurrent or severe forms of LCH.</p>..."

Amyloid Fibrillation of a Ninjurin-1-Derived α‑Helical Peptide: Structural Insights into Conformational Transition מאת Meijiao Wang (3406706)

"...We further resolved the twisted fibril structures of HE30 by cryo-EM, revealing two distinct fibril polymorphs stabilized by both hydrophobic and electrostatic interactions. ..."

DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopath... מאת Benjamin Cathcart (21247019)

"...<p> An intrinsic feature of gene transcription is the formation of DNA superhelices near the transcription bubble, which are resolved upon induction of transient double-stranded breaks (DSBs) by topoisomerases. ..."

Image_2_Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis.jpeg מאת Selma Olsson Åkefeldt (11982299)

"...Finally, these preclinical data support that targeting both Mcl-1 and BCL2A1 with low-dose vinblastine and anti-IL-17A biotherapy may represent a synergistic combination for managing recurrent or severe forms of LCH.</p>..."

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots מאת Marianna Colasuonno (5982593)

"...In murine mesentery venules, the intravenous administration of 2.5 mg/kg of tPA-DPNs resolves almost 90% of the blood clots, whereas a similar dose of free tPA successfully recanalizes only about 40% of the treated vessels. ..."

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots מאת Marianna Colasuonno (5982593)

"...In murine mesentery venules, the intravenous administration of 2.5 mg/kg of tPA-DPNs resolves almost 90% of the blood clots, whereas a similar dose of free tPA successfully recanalizes only about 40% of the treated vessels. ..."

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots מאת Marianna Colasuonno (5982593)

"...In murine mesentery venules, the intravenous administration of 2.5 mg/kg of tPA-DPNs resolves almost 90% of the blood clots, whereas a similar dose of free tPA successfully recanalizes only about 40% of the treated vessels. ..."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Reactions of Diamidonaphthalene-Bridged Diiridium Tetrahydrides with Alkynes:  Hydrogenation, Vinylidene Formation, and Catalytic C−C Coupling מאת M. Victoria Jiménez (2457487)

"...A similar reaction with bis(trimethylsilyl)acetylene forms the bis-vinylidene complex [Ir₂{μ-1,8-(NH)₂C₁₀H₆){CC(SiMe₃)₂}₂(P<i>i</i>Pr₃)₂] (<b>11</b>) together with 2 equiv of H₂CC(SiMe₃)₂. ..."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Facile E−E and E−C Bond Activation of PhEEPh (E = Te, Se, S) by Ruthenium Carbonyl Clusters: Formation of Di- and Triruthenium Complexes Bearing Bridging dppm and Phenylchalcogenid... מאת Noorjahan Begum (2388037)

"...Compounds <b>3</b>, <b>6</b>, <b>7</b>, and <b>10</b> exhibit restricted fluxional behavior involving the μ-EPh moieties...."

Systematic Heterodinuclear Complexes with MM′(μ-meppp) Centers That Tune the Properties of a Nesting Hydride (M = Ni, Pd, Pt; M′ = Rh, Ir; H₂meppp = <i>meso</i>-1,3-Bis[... מאת Bunsho Kure (1536136)

"...The reaction is assumed to involve an alkenyl complex, [Ni­(μ-meppp)­RhCp*­(CHCHPh)]­NO₃ (<b>9a</b>), formed through an insertion of phenylacetylene into the metal–hydride bond. ..."

Systematic Heterodinuclear Complexes with MM′(μ-meppp) Centers That Tune the Properties of a Nesting Hydride (M = Ni, Pd, Pt; M′ = Rh, Ir; H₂meppp = <i>meso</i>-1,3-Bis[... מאת Bunsho Kure (1536136)

"...The reaction is assumed to involve an alkenyl complex, [Ni­(μ-meppp)­RhCp*­(CHCHPh)]­NO₃ (<b>9a</b>), formed through an insertion of phenylacetylene into the metal–hydride bond. ..."

[Mn₁₂O₁₂(OMe)₂(O₂CPh)₁₆(H₂O)₂]^2- Single-Molecule Magnets and Other Manganese Compounds from... מאת Anastasios J. Tasiopoulos (1397299)

"...A new synthetic procedure has been developed in Mn cluster chemistry involving reductive aggregation of permanganate (MnO₄^-) ions in MeOH in the presence of benzoic acid, and the first products from its use are described. ..."

NSs acts as E3 ubiquitin ligase on RIG-I CARDs. מאת Gianni Gori Savellini (8103134)

"...The specificity of the E3 ubiquitin ligase activity of wt-NSs was evaluated in the <i>in vitro</i> ubiquitination assay using UbcH5b/c as E2 and recombinant p53 protein as acceptor target for ubiquitination (right panel). Poly-ubiquitinated forms were detected by anti-6xHis tag and anti-ubiquitin antibodies. ..."

Genetic analysis of Ghanaian G1P[8] and G9P[8] rotavirus A strains reveals the impact of P[8] VP4 gene polymorphism on P-genotyping מאת Susan Afua Damanka (6786065)

"...The G1 VP7 sequences of the study strains formed a monophyletic cluster with African G1P[8] strains, previously detected in Ghana and Mali during the RotaTeq vaccine trial as well as Togo. ..."

Consumption and the Industry (Panel 8) מאת Elke Weissmann (18176218)

"...The paper proposes that classic television forms will merge with digital developments in the future. ..."