Viral inclusions are biomolecular condensates containing single- and double-membranes inside. 由 Sílvia Vale-Costa (282115)

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ATG9A depletion affects viral genome assembly but not viral genome packaging. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low) were infected with PR8 virus for 12 h at an MOI of 3. 由 Sílvia Vale-Costa (282115)

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ATG9A impacts viral inclusions independently of Rab11a–vRNP interaction. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low) were infected with PR8 virus for 12 h at an MOI of 3. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low, magenta) were treated with siRNA targeting ATG9A (siATG9A) for 48 h. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low, magenta) were treated with siRNA non-targeting (siNT) for 48 h. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low) were mock-infected with PR8 virus for 12 h at an MOI of 3. 由 Sílvia Vale-Costa (282115)

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ATG9A distribution is altered during IAV infection. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low, magenta) were treated with siRNA non-targeting (siNT) for 48 h. 由 Sílvia Vale-Costa (282115)

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Functionally active Rab11a is critical for montage of viral inclusions and for viral production. 由 Sílvia Vale-Costa (282115)

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Cells (A549) were infected with PR8 virus for 12 h, at an MOI of 3. 由 Sílvia Vale-Costa (282115)

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ATG9A depletion elongates viral inclusions. 由 Sílvia Vale-Costa (282115)

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Effect of depleting autophagy factors on mock-infected cells. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low, magenta) were treated with siRNA targeting ATG9A (siATG9A) for 48 h. 由 Sílvia Vale-Costa (282115)

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IAV infection impairs Rab11a-regulated recycling and sustains the dynamics of viral inclusions. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a DN^low) were infected with PR8 virus for 12 h, at an MOI of 3. 由 Sílvia Vale-Costa (282115)

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ATG9A affects viral inclusion movement on microtubules, but not on the actin cytoskeleton. 由 Sílvia Vale-Costa (282115)

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Proposed model for ATG9A role in the establishment of liquid IAV inclusions. 由 Sílvia Vale-Costa (282115)

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Cells (GFP-Rab11a WT^low, green) were simultaneously transfected with a plasmid encoding mCherry tagged to the ER (magenta) and infected with PR8 virus for 12 h at an MOI... 由 Sílvia Vale-Costa (282115)

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