DDX6 interacts with PATL1. ‌ Donald B. Bloch (12423021)

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Interpreting persistent health problems: The chronic Lyme disease diagnosis. ‌ C. Puppo (14593159)

Խորագրեր: “…diagnostic procedure involved…”

The N-terminus of EDC4 is not required for interaction with DCP1a. ‌ Donald B. Bloch (12423021)

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Interaction between PATL1 and EDC4 requires the presence of the C-terminus of PATL1 and the N-terminus of EDC4. ‌ Donald B. Bloch (12423021)

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NLS-EDC4 localizes to Cajal bodies, and adjacent to PML-nuclear bodies. ‌ Donald B. Bloch (12423021)

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When expressed in HEp-2 cells, GFP-NLS-EDC4 (panel a) localized to Cajal bodies (panels b, c). ‌ Donald B. Bloch (12423021)

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Model of the mammalian mRNA P-body. ‌ Donald B. Bloch (12423021)

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The representations of chronic Lyme disease diagnosis. ‌ C. Puppo (14593159)

Խորագրեր: “…diagnostic procedure involved…”

Schematic of P-body proteins and fragments of proteins that were used in this study. ‌ Donald B. Bloch (12423021)

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Study’s main results. ‌ C. Puppo (14593159)

Խորագրեր: “…diagnostic procedure involved…”

EDC4 interacts with XRN1. ‌ Donald B. Bloch (12423021)

Խորագրեր:

After depletion of DDX6 and loss of endogenous P bodies, EDC4(630–1437), but not full-length EDC4, was able to localize to cytoplasmic dots. ‌ Donald B. Bloch (12423021)

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After depletion of LSm14a and loss of endogenous P-bodies, GFP-EDC4(630–1437), but not GFP-EDC4, localizes to cytoplasmic dots. ‌ Donald B. Bloch (12423021)

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Endogenous LSm14a and DDX6 did not co-localize with NLS-EDC4 in nuclear dots. ‌ Donald B. Bloch (12423021)

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Co-immunoprecipitation was used to show that the N-terminus of EDC4 is required for interaction with XRN1(1232–1706). ‌ Donald B. Bloch (12423021)

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Characteristics of the study population (n = 24). ‌ C. Puppo (14593159)

Խորագրեր: “…diagnostic procedure involved…”

The experience of uncertainty. ‌ C. Puppo (14593159)

Խորագրեր: “…diagnostic procedure involved…”

Effect of an exogenous nuclear localization sequence (NLS) on the cellular location of P-body components. ‌ Donald B. Bloch (12423021)

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Full-length PATL1 interacts with EDC4. ‌ Donald B. Bloch (12423021)

Խորագրեր:

EDC4(630–1437) can recruit DCP1a, EDC3 or CCHCR1 to cytoplasmic dots despite depletion of LSm14a and loss of endogenous P-bodes. ‌ Donald B. Bloch (12423021)

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