Metal–Organic–Inorganic Nanocomposite Thermal Interface Materials with Ultralow Thermal Resistances по Cengiz Yegin (3820723)

“...Herein, we report a new class of TIMs involving the chemical integration of boron nitride nanosheets (BNNS), soft organic linkers, and a copper matrixwhich are prepared by the chemisorption-coupled electrodeposition approach. ...”

Surfactant Lipidomics in Healthy Children and Childhood Interstitial Lung Disease по Matthias Griese (46185)

“...In other alveolar disorders lipidomic profiles may be of less diagnostic value, but nevertheless may substantiate lack of significant involvement of mechanisms related to surfactant lipid metabolism....”

Effect of Water on the Local Structure and Phase Behavior of Imidazolium-Based Protic Ionic Liquids по Negin Yaghini (1681561)

“...Supported by the appearance of some additional features in the 800–1000 cm^–1 frequency range where ring out-of-plane bending (γ) modes are found, we hypothesize that in C₂HImTFSI water interacts only with the cation coordinating to the ring C²H and the N³H sites, while it interacts with both cation and anion in C₂HImTfO forming hydrogen bonds that involve the cationic N–H site as well as the anionic −SO₃ group. ...”

2<i>H</i>‑Azirine-2-carbonyl Azides: Preparation and Use as N‑Heterocyclic Building Blocks по Liya D. Funt (3227979)

“...Heating of 2-(azidocarbonyl)-1<i>H</i>-pyrroles for a short time in inert solvents leads to the high-yield formation of benzo- and hetero-fused 1<i>H</i>-pyrrolo­[2,3-<i>b</i>]­pyridin-6­(7<i>H</i>)-ones, which are formed via a 6π electrocyclization involving the vicinal aryl or hetaryl substituent and the NC bond of isocyanate, generated by the Curtius rearrangement of the azidocarbonyl group. ...”

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor по Elton Zeqiraj (279501)

“...The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. ...”

Enterohemorrhagic <i>Escherichia coli</i> Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis по Martina Bielaszewska (79970)

“...The ability of OMV-associated EHEC-Hly to trigger the mitochondrial apoptotic pathway in human microvascular endothelial and intestinal epithelial cells indicates a novel mechanism of EHEC-Hly involvement in the pathogenesis of EHEC diseases. The OMV-mediated intracellular delivery represents a newly recognized mechanism for a bacterial toxin to enter host cells in order to target mitochondria....”

Redirection of platelet miR-140-3p targeting upon a 1-nt shift of the 5′ cleavage site. по Hélène Plé (114528)

“...Base pairing complementarity between miR-140-3p microRNAs and their binding sites is shown in the upper panel. Base pairing involving the microRNA seed region is highlighted in color. ...”

Mechanistic dissection of macro- and micronucleophagy по Florian B. Otto (8440416)

“...Our study thus details the involvement of Atg8 in both macronucleophagy and PMN and identifies Atg39 as the general cargo receptor for nucleophagic processes....”

Drafting the CLN3 Protein Interactome in SH-SY5Y Human Neuroblastoma Cells: A Label-free Quantitative Proteomics Approach по Enzo Scifo (1930765)

“...One of the most prevalent forms of NCL, Juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3 disease (OMIM: 204200), is caused by mutations in the <i>CLN3</i> gene on chromosome 16p12.1. ...”

Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition по Verena Boschert (408004)

“...To further examine the structural requirements for Wnt inhibition, we performed an extensive mutational study within all three loops of the Sclerostin core domain involving single and multiple mutations as well as truncation of important regions. ...”

An investigation of the effects of transition metal compounds on the heat stabilisation of polyorganosiloxanes по William David Brown (12518395)

“...<p>The heat stabilising effects of ferric oxide and ferric octoate in polyorganosiloxanes have been examined by measurement of weight loss, hardness change, compression stress relaxation, reduced viscosity and cross-link density along with infra-red and differential thermal analysis. Systems involving gum stock both with and without stabiliser and in the vulcanised and unvulcanised states have been examined over a temperature range 150-300°C in air. ...”

Drafting the CLN3 Protein Interactome in SH-SY5Y Human Neuroblastoma Cells: A Label-free Quantitative Proteomics Approach по Enzo Scifo (1930765)

“...One of the most prevalent forms of NCL, Juvenile neuronal ceroid lipofuscinosis (JNCL) or CLN3 disease (OMIM: 204200), is caused by mutations in the <i>CLN3</i> gene on chromosome 16p12.1. ...”

Conformational Polymorphism: The Missing Phase of 1,1,2,2-Tetrachloroethane (Cl₂HC–CHCl₂) по Ph. Negrier (1964737)

“...Halogenoethane derivatives are known to exhibit different polymorphs involving a different translational, orientational, and conformational order. ...”

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents по Jürgen Brojatsch (11776)

“...The cathepsin B-selective inhibitor CA-074-Me blocks all forms of programmed necrosis by an unknown mechanism. ...”

Regulating Factors of PrP^res Glycosylation in Creutzfeldt-Jakob Disease - Implications for the Dissemination and the Diagnosis of Human Prion Strains по Etienne Levavasseur (94459)

“...</p><h3>Interpretation</h3><p>Regulations leading to variations of PrP^res pattern between brain regions in sCJD patients, involving host genotype and Western blot type of PrP^res may contribute to the specific brain targeting of prion strains and have direct implications for the diagnosis of the different forms of CJD....”

Mechanistic Insight into Fragmentation Reactions of Titanapinacolate Complexes по Jesudoss V. Kingston (2314027)

“...Because metallapinacolate intermediates have been implicated in important C−C bond-forming reactions, such as pinacol coupling and McMurry chemistry, the mechanism of the fragmentation reactions was studied. ...”

Data Sheet 3_Integrated analysis of fecal microbiota and metabolomics reveals unique characteristics of asymptomatic and classic celiac disease.csv по Shanxia Yao (21676265)

“...Introduction<p>Celiac Disease (CeD) is an autoimmune small intestinal disorder triggered by gluten, with clinical subtypes including typical, atypical, and asymptomatic forms.While classic CeD development is linked to microbes/metabolites, their relationships with other subtypes remain unclear....”

Inter- and Intramolecular Interactions in Some Bromo- and Tricyanovinyl-Substituted Thiophenes and Ethylenedioxythiophenes по Phuong-Truc T. Pham (1838419)

“...On the other hand, new dimeric motifs are formed in Br-EDOT-TCV as strong S···N (3.03 Å) intermolecular interactions in TCV-EDOT are replaced by competing N···Br (2.99 Å) interactions. ...”

Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes по Subbiah Jeeva (4442956)

“...Although the role of dual RNA binding modes in the virus replication cycle is unknown, their involvement in the packaging of viral genome and regulation of CCHFV replication in conjunction with RdRp and host derived RNA regulators is highly likely....”

Table_5_The Selection of a Hepatocyte Cell Line Susceptible to Plasmodium falciparum Sporozoite Invasion That Is Associated With Expression of Glypican-3.XLSX по Rebecca E. Tweedell (6408542)

“...We identified and investigated a hepatocyte cell surface heparan sulfate proteoglycan, glypican-3, as a putative mediator of sporozoite invasion. We also noted the involvement of pathways that implicate the importance of the metabolic state of the hepatocyte in supporting LS development. ...”