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PICS: A Sequential Approach to Obtain Optimal Designs for Nonlinear Models Leveraging Closed-Form Solutions for Faster Convergence
Foilsithe / Cruthaithe 2025“…On the other hand, there are many nonlinear models for which closed-form results for D-optimal designs are available, but because such solutions involve the parameters to be estimated, they can only be used by substituting “guesstimates” of parameters. …”
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List of organisms used as a negative control in our σ<sup>54</sup>-specific EBP search.
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Isolation of EVs shed by trypomastigotes of <i>T. cruzi</i> Pan4 strain.
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BNP serum levels obtained after inoculation of animals with EVs (green) and ICs (blue) when compared to the negative control (red).
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Analysis of connexin 43 expression in mice inoculated intravenously with EVs (green) or ICs (blue).
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Computational Insights into Glucose Tolerance and Stimulation in a Family 1 β‑glucosidase
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Heart morphological alterations induced by EVs (green) and ICs (blue).
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Humoral immune response observed in mice after the inoculation with EVs (green) or ICs (blue).
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Decreased synthesis of VCAM-1, tubulin and dynein proteins in the heart of mice stimulated with EVs (green) or ICs (blue).
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Effects of EVs (green) or immune complexes (blue) on mice cardiac activity.
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Graphical abstract of the experimental design, indicating the moments of the interventions and experiments carried out.
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Antigenic recognition of a trypomastigote lysate by the sera of the different experimental mouse groups was assessed by indirect ELISA.
Foilsithe / Cruthaithe 2025Ábhair: