Can a Butadiene-Based Architecture Compete with its Biaryl Counterpart in Asymmetric Catalysis? Enantiopure Me-CATPHOS, a Remarkably Efficient Ligand for Asymmetric Hydrogenation per Simon Doherty (1737616)

“…<i>rac</i>-Me-CATPHOS can be resolved by fractional crystallization of the diastereoisomeric complexes formed with (2<i>R</i>,3<i>R</i>)-(−)-2,3-<i>O</i>-dibenzoyltartaric acid and reduction of the resulting enantiopure oxide, accomplished by silane reduction in xylene at 130 °C, to afford an operationally straightforward, three-step synthesis of an entirely new class of atropos buta-1,3-diene-based diphosphine. …”

Screening for chaperone mutant cells with elevated levels of heat stress-associated transcription. per Aleksandar Vjestica (262087)

“…An additional sample of wild type cells was shifted to 36°C for 45 min before being transferred to 50°C for 15 min (purple line). Number of colony forming units was measured for each sample and used to calculate survival rates. …”

High-Density Inverted Micellar Intermediates Promote Membrane Fusion of Cationic Liposomes in Drug Delivery per Rejhana Kolašinac (21724043)

“…At 25 °C and below, mainly a lamellar phase formed without elevated membrane fusion capacity. …”

Topochemistry and Photomechanical Effects in Crystals of Green Fluorescent Protein-like Chromophores: Effects of Hydrogen Bonding and Crystal Packing per Panče Naumov (1474312)

“…Due to the asymmetric substitution with hydrogen bond donors and acceptors, <b>3-HOBDI</b> is tetramorphic, the forms showing distinctly different structure and behavior: (1) while one of the polymorphs (<b>3-HOBDI</b>-A), having multilayer structure with alternating stereochemistry of linear hydrogen-bonded motifs, undergoes photodimerization under UV light, (2) another (<b>3-HOBDI</b>-C), which has dimeric head-to-tail structure, shows <i>Z</i>-to-<i>E</i> isomerization via τ-one-bond flip of the imidazolone ring by excitation in the visible region. …”

Sequence analysis and expression of rice ceramide kinase (<i>OsCERK</i>) <i>in planta</i>. per Fang-Cheng Bi (226018)

“…Arrows in (E and F) indicated the formed product C6-NBD-ceramide-1-phosphate (C6-NBD-Cer-1P).…”

Depletion of HOPS subunits impairs <i>Salmonella</i> replication. per Aastha Sindhwani (4543993)

“…The number of colony forming units (CFU) per well are shown as dot plot and data represent mean ± S.D. …”

Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a “Polar Gate” in Stereorecognition of Diaryl Ketones per Jieyu Zhou (707672)

“…The crystal structures of <i>Kp</i>ADH and two mutants in complex with NADPH were resolved to elucidate the evolution of enantioselective inversion. …”

Micro-Data-Independent Acquisition for High-Throughput Proteomics and Sensitive Peptide Mass Spectrum Identification per Michael R. Heaven (2812981)

“…Additionally, we found the μDIA MS/MS deconvolution procedure is critical for resolving modified peptides with relatively small precursor mass shifts that cause the same peptide sequence in modified and unmodified forms to theoretically cofragment in the same raw MS/MS spectra. …”

Topochemistry and Photomechanical Effects in Crystals of Green Fluorescent Protein-like Chromophores: Effects of Hydrogen Bonding and Crystal Packing per Panče Naumov (1474312)

“…Due to the asymmetric substitution with hydrogen bond donors and acceptors, <b>3-HOBDI</b> is tetramorphic, the forms showing distinctly different structure and behavior: (1) while one of the polymorphs (<b>3-HOBDI</b>-A), having multilayer structure with alternating stereochemistry of linear hydrogen-bonded motifs, undergoes photodimerization under UV light, (2) another (<b>3-HOBDI</b>-C), which has dimeric head-to-tail structure, shows <i>Z</i>-to-<i>E</i> isomerization via τ-one-bond flip of the imidazolone ring by excitation in the visible region. …”

ALK Kinase Domain Mutations in Primary Anaplastic Large Cell Lymphoma: Consequences on NPM-ALK Activity and Sensitivity to Tyrosine Kinase Inhibitors per Federica Lovisa (721555)

“…Functional changes in ALK kinase activity induced by both point mutations and structural rearrangements were resolved by molecular modelling and dynamic simulation analysis, providing novel insights into ALK kinase domain folding and regulation. …”

Multiplex PCR demonstrates allelic variation at the 165 kb duplication locus. per Zhongmeng Bao (115141)

“…This region is more than 22 kb downstream from the 165 kb duplicated region and most likely formed as a result of mis-priming.</p>…”

Structural Diversity in Supramolecular Complexes of MCl₃ (M = As, Sb, Bi) with Constrained Thio- and Seleno-Ether Ligands per William Levason (1275612)

“…[BiCl₃{<i>o</i>-C₆H₄(SeMe)₂}] comprises distorted square pyramidal units involving pyramidal BiCl₃ primary coordination and a weakly chelating diselenoether ligand, and assembled into infinite chains through long bridging Bi···Cl interactions via all three Clʼs. …”

Structure and features of ExChrs. per Alexander Woglar (204503)

“…In 18 of the 21 lines, ExChrs could be detected as additional HTP-3-positive structures in meiotic prophase nuclei, and in 16 of these 18 cases, the ExChrs were reliably resolvable as rings by SIM in partially spread gonads; as the 2 ExChrs that were not verified as rings were the smallest of the 18, we speculate that they may also be rings, but their small size prevented their ring structure from being resolved microscopically. …”

Preparation, Structure, and Properties of the Corner-Shared Double Cubes [Mo₆HgQ₈(H₂O)₁₈]⁸⁺ (Q = S, Se) and Tungsten Analogue... per Vladimir P. Fedin (1491637)

“…Furthermore, on dilution of column-purified [Mo₆HgS₈(H₂O)₁₈]⁸⁺, Beer's law is not obeyed and equilibria involving 2[Mo₃S₄(H₂O)₉]⁴⁺ are apparent. …”

File S1 - The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination per Rebecca C. Burgess (500370)

“…After the addition of gel loading buffer, the reaction mixtures were resolved in a 10% polyacrylamide gel in TBE buffer. …”

Models for meiotic CO formation. per Emmanuelle Martini (203348)

“…Migration of the D-loop can partially (not shown) or completely erase the first hDNA formed after strand invasion as shown here. The ligated dHJ can be resolved (a) or can keep migrating away from the invasion point (b and c). dHJ migration within a homoduplex DNA generates an aberrant 4∶4 tract or symmetric hDNA tract (indicated by a star), that corresponds to the region encompassed by the two HJs. …”

DataSheet1_Two mixed-valent cerium oxo clusters: synthesis, structure, and self-assembly.pdf per Yuan Gao (159945)

“…X-ray photoelectron spectra (XPS) revealed that the white precipitates formed during the preparation of Ce₁₄ contain Ce(III) ions, while the reddish-brown precipitates formed during the preparation of Ce_24C contain a mixture of Ce(III) and Ce(IV) ions. …”

E06918: Aldhelm's poem On the Church of Mary Built by Bugga records the consecration on 15/16 August of a church with an apse dedicated to *Mary (Mother of Christ, S00033), constru... per bsavill (10125827)

“…The new church has many ornaments: a golden cloth glistens with its twisted threads and forms a beautiful covering for the sacred altar. …”

SARS-CoV-2 RBDs with Q498H mutations have high affinity for ACE2. per Neil Bate (173464)

“…<p><b>(a)</b> Soluble forms of HuACE2, WH-RBD and mutant RBD were expressed in HEK 293 cells and purified on nickel affinity columns. …”

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots per Marianna Colasuonno (5982593)

“…In murine mesentery venules, the intravenous administration of 2.5 mg/kg of tPA-DPNs resolves almost 90% of the blood clots, whereas a similar dose of free tPA successfully recanalizes only about 40% of the treated vessels. …”