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    Stable Isotope Labeling of Pyrimidines Using a Deconstruction–Reconstruction Strategy Yazar: Benjamin J. H. Uhlenbruck (22267064)

    Baskı/Yayın Bilgisi 2025
    “…By deconstructing pyrimidines into vinamidinium salts and reconstructing them with deuterium, <sup>13</sup>C, and <sup>15</sup>N-enriched amidines, we achieve high isotopic enrichment across various substitution patterns, including complex drug-like pyrimidine derivatives. The process involves a Tf<sub>2</sub>O-mediated ring-opening and ring-closing sequence to form a pyrimidinium ion, followed by cleavage to the vinamidinium salt with pyrrolidine. …”
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