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The Timing of Drug Funding Announcements Relative to Elections: A Case Study Involving Dementia Medications
Publicado em 2013“...The role of political pressures on drug funding announcements has received relatively little attention, and elections represent an especially powerful form of political pressure. ...”
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Crystal Engineering of the Composition of Pharmaceutical Phases: Multiple-Component Crystalline Solids Involving Carbamazepine
Publicado em 2003“...The crystal engineering design strategy facilitates supramolecular synthesis of 13 new crystalline phases of carbamazepine (CBZ), an analgesic and anticonvulsant with known problems related to solubility and polymorphism. CBZ forms supramolecular complexes with the following molecules, all of which are complementary to CBZ in terms of hydrogen bonding and can therefore act as cocrystal formers: acetone (<b>1a</b>); DMSO (<b>1b</b>); benzoquinone (<b>1c</b>); terephthalaldehyde (<b>1d</b>); saccharin (<b>1e</b>); nicotinamide (<b>1f</b>); acetic acid (<b>1g</b>); formic acid (<b>1h</b>); butyric acid (<b>1i</b>); trimesic acid (<b>1j</b>); 5-nitroisophthalic acid (<b>1k</b>); adamantane-1,3,5,7-tetracarboxylic acid (<b>1l</b>); and formamide (<b>1m</b>). ...”
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<i>B</i>. <i>besnoiti</i> orthologues involved in sexual reproduction and oocyst formation.
Publicado em 2022Assuntos: -
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Topologies derived from maximum likelihood analyses of two protein families involved in the apoptosis pathway.
Publicado em 2024Assuntos: -
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Autophagy Induced by Calcium Phosphate Precipitates Involves Endoplasmic Reticulum Membranes in Autophagosome Biogenesis
Publicado em 2012“...We previously reported that exogenously introduced calcium in the form of calcium phosphate precipitates (CPP) induces autophagy. ...”
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Mammalian Sperm Head Formation Involves Different Polarization of Two Novel LINC Complexes
Publicado em 2010“...<div><h3>Background</h3><p>LINC complexes are nuclear envelope bridging protein structures formed by interaction of SUN and KASH proteins. They physically connect the nucleus with the peripheral cytoskeleton and are critically involved in a variety of dynamic processes, such as nuclear anchorage, movement and positioning and meiotic chromosome dynamics. ...”
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SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in <i>Trypanosoma brucei</i> procyclic forms
Publicado em 2018“...<div><p>SUMOylation is a post-translational modification conserved in eukaryotic organisms that involves the covalent attachment of the small ubiquitin-like protein SUMO to internal lysine residues in target proteins. ...”
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