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Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions <i>in Vitro</i> and in Patient Samples
Julkaistu 2019“…However, the recent discovery of new reactive metabolites (RM) with aldehyde structures during pazopanib and sunitinib metabolism offers new perspectives for investigating their involvement in the toxicity of these two TKI. These hard electrophiles have a high reactivity potential toward proteins and are thought to be responsible for cytochrome P450 inactivation, drug–drug interactions (DDI), and liver toxicity. …”
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Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions <i>in Vitro</i> and in Patient Samples
Julkaistu 2019“…However, the recent discovery of new reactive metabolites (RM) with aldehyde structures during pazopanib and sunitinib metabolism offers new perspectives for investigating their involvement in the toxicity of these two TKI. These hard electrophiles have a high reactivity potential toward proteins and are thought to be responsible for cytochrome P450 inactivation, drug–drug interactions (DDI), and liver toxicity. …”
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Data_Sheet_1_On Lies and Hard Truths.PDF
Julkaistu 2021“…<p>We run an experimental study using sender-receiver games to evaluate how senders' willingness to lie to others compares to their willingness to tell hard truths, i.e., promote an outcome that the sender knows is unfair to the receiver without explicitly lying. …”
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