Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions <i>in Vitro</i> and in Patient Samples per Marie-Noëlle Paludetto (5683055)

“…However, the recent discovery of new reactive metabolites (RM) with aldehyde structures during pazopanib and sunitinib metabolism offers new perspectives for investigating their involvement in the toxicity of these two TKI. These hard electrophiles have a high reactivity potential toward proteins and are thought to be responsible for cytochrome P450 inactivation, drug–drug interactions (DDI), and liver toxicity. …”

Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug–Drug Interactions <i>in Vitro</i> and in Patient Samples per Marie-Noëlle Paludetto (5683055)

“…However, the recent discovery of new reactive metabolites (RM) with aldehyde structures during pazopanib and sunitinib metabolism offers new perspectives for investigating their involvement in the toxicity of these two TKI. These hard electrophiles have a high reactivity potential toward proteins and are thought to be responsible for cytochrome P450 inactivation, drug–drug interactions (DDI), and liver toxicity. …”

A map of the Central Region of Ghana with a zoom-in of the Agona Abodom community showing the spatial distribution of the water contact sites and houses of the 114 participants inv... per Elias K. Asuming-Brempong (12219257)

2D visualization of the HDBSCAN results on the journalists dataset with both hard and soft clustering. per Kilian Ollivier (14159864)

Illustrating alternative strategies involving MDA and testing in the study area (102 EAs 67,156 people) whose costs are compared. per Emma Harding-Esch (372207)

Table 1_Hard to jump: host shifts appear unlikely in a T4-like phage evolved in the lab.xlsx per Yu Ning (588573)

Since early dinosaurs, birds have reduced the number of bones in their wrist, but the origins and identity of those remaining are hard to trace. per Robin Meadows (583448)

Supplementary file 1_Hard to jump: host shifts appear unlikely in a T4-like phage evolved in the lab.docx per Yu Ning (588573)

Schematic representation of the architectures of the hard parameter model (left), the MMoE model (middle), and the MMoEEx model (right). per Jonas Verhellen (19267988)

Table 1_Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.docx per Masaki Yasuhara (20626676)

“…Post-hoc analyses revealed that the classifier trained on single-task ErrPs exhibited reduced accuracy under hard-task scenarios. To our knowledge, this study is the first to investigate how ErrPs are modulated in a multitasking environment involving both sensorimotor control and BCI operation in an offline framework. …”

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action per Inês Barroso (2144)

Ever smoking at 11-23y: The influence of racism, ethnicity, parenting and religious involvement, socio-economic circumstances: Odds ratio (95% confidence interval). per Ursula M. Read (4794432)

Smoking initiation at 14-16y: The influence of racism, ethnicity, parenting and religious involvement, socio-economic circumstances: Odds ratio (95% confidence interval). per Ursula M. Read (4794432)

Ever smoking at 11-16y: The influence of racism, ethnicity, parenting and religious involvement, socio-economic circumstances: Odds ratio (95% confidence interval). per Ursula M. Read (4794432)

Approximate distances and residues involved in the coordination of Mn²⁺ in the best-defined (chain C) active site of Form A (7txg). per Anna I. Selezneva (16437417)

DataSheet1_Large-Scale Implementation of Bioenergy With Carbon Capture and Storage in the Swedish Pulp and Paper Industry Involving Biomass Supply at the Regional Level.docx per Sebastian Karlsson (11574526)

Additional file 1 of Genomic Regions Involved in Differences in Eating and Cooking Quality Other than Wx and Alk Genes between indica and japonica Rice Cultivars per Kiyosumi Hori (9959182)

DataSheet_1_Case Report: Blurred Vision and Eruptive Nevi - Bilateral Diffuse Uveal Melanocytic Proliferation With Mucocutaneous Involvement in a Lung Cancer Patient.docx per David Rafei-Shamsabadi (10588496)

“…Further skin involvement of the perineal and perianal region, mamillae and oral mucosa was stated. …”

Effect of BDSW on expression of genes involved in fatty acid oxidation, oxidative phosphorylation, and mitochondrial dynamic in C₂C₁₂ myotubes. per Byung Geun Ha (597017)

Differential expression of genes involved in efflux, ATP generation, respiration, LPS transport and secretion during monotherapy or combination therapy with respect to untreated <i... per Samuel Kraus (18934096)