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System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases
Published 2022“…Initially, the study identified 385 up-regulated genes and 338 down-regulated genes involved with RCC. …”
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Identifying genetic traces of historical expansions
Published 2008“…Our methodology can be applied to any historically documented expansion in which contact and noncontact sites can be identified.…”
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Machine Learning based Model Reveals the Metabolites Involved in Coronary Artery Disease
Published 2025“…</p><h3>Methods</h3><p dir="ltr">This article presents machine learning (ML) based model that can recognize metabolomic compounds associated with CAD in the Qatari population for the early detection of CAD. We also identified statistically significant metabolic profiles and potential biomarkers using ML methods.…”
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Coevolving residues distant from the ligand binding site are involved in GAF domain function
Published 2025“…However, the specific residues involved and the mechanism of GAF domain function remain unclear. …”
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Identifying the Impact of the Critical Success Factors on the Success of IT Projects in UAE
Published 2018“…This research study aims to identify the critical success factors (CSF's) that are required in implementing success information technology (IT) projects in UAE. …”
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A survey of the European Society of Clinical Pharmacy members’ research involvement, and associated enablers and barriers
Published 2022“…Results The response rate was 16.7% (83/499), with 89.2% (n = 74) involved in research and 79.5% (n = 66) publishing research in the preceding 2 years. …”
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Identifying Employee Turnover Risks Using Modified Quality Function Deployment
Published 2014“…Employee turnover risk identification mainly involves employee turnover risk factors modelling, identifying risk factors' index, and determining index weights. …”
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Gene expression data analysis identifies multiple deregulated pathways in patients with asthma
Published 2018“…The presented profile suggests that genes involved in asthma progression are different from those involved in the response to corticosteroids and this could affect the clinical management of different groups of patients with asthma.…”
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Proteomic insight towards key modulating proteins regulated by the aryl hydrocarbon receptor involved in ovarian carcinogenesis and chemoresistance
Published 2024“…STRING interaction analysis and KEGG-Reactome pathway analysis approaches identified several significantly dysregulated proteins that were categorized to be involved in chemoresistance, cancer progression, invasion and metastasis, apoptosis, survival, and prognosis in OC. …”
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High-throughput autoantibody screening identifies differentially abundant autoantibodies in autism spectrum disorder
Published 2023“…</p><h3>Conclusion</h3><p dir="ltr">This study explored autoantibody reactivity against self-antigens in ASD individuals' serum using a high-throughput assay. The identified autoantibodies were reactive against proteins involved in axonal guidance, synaptic function, amino acid metabolism, fatty acid metabolism, and chromatin binding.…”
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Large-scale association analysis identifies new risk loci for coronary artery disease
Published 2013“…Our study provides insights into the genetic basis of CAD and identifies key biological pathways.…”
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Proteomic analysis of a Candida albicans pir32 null strain reveals proteins involved in adhesion, filamentation and virulence
Published 2018“…We have previously characterized Pir32, a Candia albicans cell wall protein that we found to be involved in filamentation, virulence, chitin deposition, and resistance to oxidative stress. …”
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Machine Learning–Based Approach for Identifying Research Gaps: COVID-19 as a Case Study
Published 2024“…Traditional methods for identifying research gaps, such as literature reviews and expert opinions, can be time consuming, labor intensive, and prone to bias. …”
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The Use of Whole Exome Sequencing in a Cohort of Transgender Individuals to Identify Rare Genetic Variants
Published 2019“…Our findings suggest a new avenue for investigation of genes involved in estrogen signaling pathways related to sexually dimorphic brain development and their relationship to gender dysphoria.…”
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Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
Published 2021“…Candidate genes at novel loci were involved in myocardial structure and arrhythmogenic cardiomyopathy. …”
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Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration
Published 2011“…To understand how antitumor drugs prevent neurodegeneration, here we use structure–activity relationships of mithramycin analogs to discover that selective DNA-binding inhibition of the drug is necessary for its neuroprotective effect. We identify several genes (Myc, c-Src, Hif1α, and p21waf1/cip1) involved in neoplastic transformation, whose altered expression correlates with protective doses of mithramycin or its analogs. …”
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A Decision Support Model for Pre-qualifying Construction Contractors using 2S-ECI
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doctoralThesis
