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Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
Published 2021“…<p dir="ltr">Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases (PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated activation of the soluble guanylyl cyclase. …”
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Dosage, time, and polytherapy dependent effects of different levetiracetam regimens on cognitive function
Published 2023“…This study aimed to evaluate the impact of different levetiracetam drug regimens on cognitive function.</p><h3>Methods</h3><p dir="ltr">A retrospective analysis identified 221 patients diagnosed with seizures who underwent cognitive screening. …”
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Effects ofS-nitroso-N-acetylcysteine on contractile function of reperfused skeletal muscle
Published 1998“…Neurotransmission, bronchodilation, glucose transport, and regulation of force development are among its functions. NOS 2 (iNOS) is induced by endotoxins and cytokines in most cells (20). …”
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LearnSmart: A framework for integrating internet of things functionalities in learning management systems
Published 2019“…In recent years, major technological enhancements transformed the LMS into powerful software for providing rich-content courseware, assessment, and dynamic collaboration. The most important technology that is expected to transform many future aspects is the Internet of Things (IoT). …”
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The impact of scoliosis surgery on pulmonary function in spinal muscular atrophy: a systematic review
Published 2022“…Given the available evidence, the following GRADE C recommendations were made: (1) surgery is most often associated with decreases in pulmonary function; (2) the impact of surgery on pulmonary function is variable, but does not improve over pre-operative baseline; (3) surgery may result in a decreased rate of decline in pulmonary function post-operatively. …”
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Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
Published 2021“…<div><p>Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased functionality. However, recent advances in high-throughput genomic technology have allowed circRNAs to be characterized in detail and revealed their role in controlling various biological and molecular processes, the most essential being gene regulation. …”
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Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study
Published 2023“…<h3>Aim</h3><p dir="ltr">We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar.…”
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Functional Validation and Network-Based Prioritization of Key Transcriptional Factors of Diabetic Kidney Disease
Published 2023“…Alshabeeb Akil (Sidra Medicine)</strong></p> <p>Background: Diabetic nephropathy (DN) is one of the most established microvascular complications of diabetes and a key cause of end-stage renal disease. …”
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Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…Herein, we investigate in vivo functional effects of these CaM mutations on the normal zebrafish embryonic heart function by microinjecting complementary RNA corresponding to CaMN98I, CaM<sup>D132E</sup>, CaM<sup>D134H</sup>, and CaM<sup>Q136P</sup> mutants. …”
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Performance of carbon hydrogen storage materials as a function of post-production thermal treatment
Published 2012“…At temperatures below 450 C, volatiles are mostly water and air; volatiles above 450 C are mostly carbon dioxide and carbon monoxide. …”
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HVAC multivariable system modelling and control
Published 2022“…Heating, Ventilation and Air Conditioning (HVAC) is a multivariable process where any alteration with one system input affects most or all of the system’s outputs simultaneously. …”
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Mobile robots obstacles avoidance using dynamic window approach
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Towards heat tolerant metagenome functional prediction, coral microbial community composition, and enrichment analysis
Published 2022“…Lastly, metagenome functional prediction was carried out and the most abundant heat tolerance related genes were highlighted.…”
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A novel pseudorandom noise and band jammer generator using a composite sinusoidal function
Published 2010“…The signals produced by the proposed generator are based on a linear combination of continuous-time composite sinusoidal functions. Numerical examples are included in order to illustrate the performance of the proposed generator.…”
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An enhanced binary Rat Swarm Optimizer based on local-best concepts of PSO and collaborative crossover operators for feature selection
Published 2022“…FS is an important data reduction step in data mining which finds the most representative features from the entire data. …”
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Higher serum uric acid is associated with poorer cognitive performance in healthy middle-aged people: a cross-sectional study
Published 2023“…Moreover, most of the previous studies investigating the association included elderly participants with memory-related diseases. …”
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Plant Protein Innovation: Optimizing Tri-Source Vegan Protein Isolates with Optimized Nutrition and Functionality
Published 2025“…Notably, MPI also presented the most stable thermal denaturation behavior (DSC) and a favorable particle charge (-37.1 mV), suggesting enhanced colloidal stability. …”
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Eradication of hepatitis C virus infection in kidney transplant recipients using direct‐acting antiviral therapy: Qatar experience
Published 2020“…Moreover, DAA therapy was well-tolerated, and kidney function remained stable without an increased risk of rejection. …”
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A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency
Published 2010“…Objective To assess ovarian follicle function in women with 46,XX spontaneous primary ovarian insufficiency. …”
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