Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif by Jianguo Zhang (6482)

“…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …”

Image 1_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg by Mouying Du (21398510)

“…</p>Results<p>In vivo, YHF treatment significantly attenuated RIF, protected renal function, increased miR-210 expression, and decreased the expression of HIF-1α, BNIP3, and NIX in the serum exosomes of UUO rats. …”

Image 2_Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.jpeg by Mouying Du (21398510)

“…</p>Results<p>In vivo, YHF treatment significantly attenuated RIF, protected renal function, increased miR-210 expression, and decreased the expression of HIF-1α, BNIP3, and NIX in the serum exosomes of UUO rats. …”

Table 1_Epidemiological characteristics and trends of pre-hospital emergency care in Handan, China from 2011 to 2024.docx by Feng Tian (121350)

“…Over the past 14 years, Handan’s pre-hospital EMS demand increased significantly by 3.11-fold (p < 0.001). The percentages of EMS patients aged 61 to 70 and over 71 years old increased significantly (p < 0.01), in contrast, the percentage of EMS patients aged 21 to 30 and 31 to 40 years old decreased significantly (p < 0.01). …”

Table 1_Electroacupuncture improves scopolamine hydrobromide induced dry eye in mice via inhibiting ocular surface inflammation and regulating the HMGB1-related signaling pathways.... by Xia Wu (203682)

“…The levels of HMGB1, RAGE, TLR2, TLR4, and IL-6 were significantly decreased while IL-10 level was significantly increased after EA treatment, indicating that EA may improve dry eye surface inflammation by inhibiting HMGB1-related signaling pathways.…”

Experiment 2, trial D. by Ottavia Benedicenti (9100619)

Image 1_REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway.jpg by Xiaonan Li (340228)

“…</p>Results<p>RNA sequencing revealed REDD1 was significantly upregulated in BDL-induced fibrotic liver tissue. …”

Effects of Feed Enriched with Freshwater Fish Oil on the Nutritional Profile and Growth Performance of Asian Redtail Catfish (Hemibagrus nemurus) Fry by Netti Aryani (7007696)

“…The results showed that feed enrichment with FFO significantly affected the composition of fatty acids, amino acids, growth performance, and survival (p<0.05). …”

Effects of Feed Enriched with Freshwater Fish Oil on the Nutritional Profile and Growth Performance of Asian Redtail Catfish (Hemibagrus nemurus) Fry by netti aryani (19985907)

“…The results showed that feed enrichment with FFO significantly affected the composition of fatty acids, amino acids, growth performance, and survival (p<0.05). …”

Structural, Morphological and Thermal Properties of Kenaf Microcrystalline Cellulose/Poly (Butylene Adipate-Co-Terephthalate) Films for Packaging Applications by Aatikah Meraj (20632855)

“…Cellulose film could potentially be used as a biodegradable film in food packaging applications.…”

Table 1_Alterations in gut–kidney axis indicators and TMAO-related biomarkers in elderly patients with hypertensive nephropathy.xlsx by Ziyi Li (349831)

“…</p>Results<p>The chronic kidney disease group exhibited elevated serum urea and creatinine and reduced eGFR, along with increased levels of KIM-1, NGAL, IL-18, TNF-α, IL-6, NF-κB, and FMO3. Urinary TMAO was significantly decreased in both hypertensive groups, while serum TMAO remained unchanged. …”

Table 1_Intramuscular iron supplementation enhances intestinal barrier function in weaned piglets challenged with enterotoxigenic Escherichia coli.docx by Chenying Tian (21731474)

“…Background<p>Since iron is an essential mineral for both host and microbial communities, how to scientifically replenish the iron in the context of bacterial infection has become a critical issue. The aim of this study was to compare the influence of intramuscular and oral iron supplementation on the progression of bacterial infection. …”

Image 2_Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice.tif by Mengshan Chen (14303892)

“…</p>Discussion<p>These findings demonstrate that L. brevis ZG2488 enhances the immune response to the SARS-CoV-2 vaccine through synergistic and multi-mechanistic actions, supporting its potential as a probiotic adjuvant strategy.</p>…”

Image 1_Immunomodulatory effects of probiotic Lactobacillus brevis ZG2488 on SARS-CoV-2 vaccine responses in mice.tif by Mengshan Chen (14303892)

“…</p>Discussion<p>These findings demonstrate that L. brevis ZG2488 enhances the immune response to the SARS-CoV-2 vaccine through synergistic and multi-mechanistic actions, supporting its potential as a probiotic adjuvant strategy.</p>…”

S1 File - by Shi-jie Wang (18569781)

“…The results showed that muscle TOR knockdown and endurance exercise significantly increased the climbing speed, climbing endurance, the expression of autophagy related gene 2(ATG2), silent information regulator 2(SIR2), and pparγ coactivator 1(PGC-1α) genes, and superoxide dismutases(SOD) activity, but it decreased the expression of the TOR gene and reactive oxygen species(ROS) level, and it protected the myofibrillar fibers and mitochondria of skeletal muscle in Drosophila on a high-salt diet. …”

DataSheet_1_RETRACTED: Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia.docx by Youfeng Zhu (2460811)

“…Depletion of macrophages protected against lung epithelial cells and significantly decreased MMP9, MMP19, FTH, and FTL expression levels and increased GPX4 expression levels, while partially reversing the changes in macrophage. …”

Data Sheet 1_Relay intercropped soybean promotes nodules development and nitrogen fixation by root exudates deposition.docx by Ping Lin (146330)

“…Compared with monocropping, the nodule number significantly decreased in relay strip intercropping soybean, and NTS achieved 97% at soybean five trifoliolate stage. …”

Analysis of rehabilitation effect of electroacupuncture for patients after total knee arthroplasty by Yufeng Song (457060)

“…Compared with the control group, the ROM and KSS of the experimental group were significantly improved at two weeks after surgery and one month after surgery, and the VAS was significantly decreased, with statistical significance (<i>p</i> < 0.05).…”

Graphical Abstract. by Furkan Özdemir (21560297)

PONE-Dataset. by Furkan Özdemir (21560297)