Data Sheet 4_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.pdf by Yingchao Wu (2870927)

“…Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized by low toxicity, demonstrating significant efficacy against breast cancer through the induction of cellular senescence.…”

Data Sheet 1_OSH45, a homeobox transcription factor, coordinates low-phosphate adaptation in rice.pdf by Hong Lu (58784)

“…<p>Phosphorus (P), an essential macronutrient critical for plant growth and development, faces significant availability constraints in agricultural soils, substantially limiting crop yield potential. …”

Data Sheet 1_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.pdf by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

Table 4_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Table 3_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.docx by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

Data Sheet 1_Decoding the hypoxia-exosome-immune triad in OSA: PRCP/UCHL1/BTG2-driven metabolic dysregulation revealed by interpretable machine learning.zip by Weilong Ye (12984647)

“…By integrating transcriptomic data, machine learning, and immune analysis, we uncover an “exosome-immune” axis in OSA pathophysiology.…”

Table 1_Impact of hearing loss on brain signal variability in older adults under different auditory load conditions.docx by Songjian Wang (18173353)

“…</p>Results<p>Results revealed that the brain signal variability increased with higher SNR loads in healthy older adults, indicating enhanced neural resource allocation with the SNR load. In contrast, we found that hearing loss reduced brain signal variability during speech recognition tasks, especially in noisy conditions, in the mild hearing loss and moderate to severe hearing loss groups, possibly indicating decreased neural processing efficiency. …”

Table 5_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Data Sheet 1_Parent soil type modulates biochar and mowing effects on soil microbial communities in karst region.docx by Xun Yi (2167936)

“…Highthroughput sequencing was used to assess microbial abundance, alpha diversity, and community structure.</p>Results<p>We found that the individual and combined effects of biochar and mowing on soil microbial communities differed significantly between soil types. …”

Supplementary Material for: The Impact of the Selective Cytopheretic Device on Neutrophil-to-Lymphocyte Ratios and Hematological Parameters in AKI: A Pooled Analysis by figshare admin karger (2628495)

“…NLR reductions in the SCD group were driven by decreases in neutrophils and increases in lymphocytes. …”

Data_Sheet_1_Liver cirrhosis is a risk-factor for Pneumocystis jirovecii associated mortality.pdf by Georg Peschel (14005905)

“…There was a significant correlation of Meld score and mortality (r = 0.612, p < 0.001).…”

Data Sheet 3_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx by Yingchao Wu (2870927)

“…Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized by low toxicity, demonstrating significant efficacy against breast cancer through the induction of cellular senescence.…”

Data Sheet 1_Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans.zip by Haiyan Zhu (110483)

“…Compared to the raw PK, the P3 stage exhibited significant increases in saponins, total sugars, organic acids, and flavonoids by 21.29, 35.02, 49.13, and 44.76%, respectively (p < 0.05), reducing sugars showed a remarkable increase of 160.94-fold (p < 0.01), while polysaccharides decreased significantly by 43.33% (p < 0.01).…”

Table 1_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.docx by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

Table 3_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Table 1_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”

Table 1_OSH45, a homeobox transcription factor, coordinates low-phosphate adaptation in rice.xlsx by Hong Lu (58784)

“…<p>Phosphorus (P), an essential macronutrient critical for plant growth and development, faces significant availability constraints in agricultural soils, substantially limiting crop yield potential. …”

Data Sheet 1_Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.pdf by Samira Rastgoo (15252703)

“…</p>Results<p>After the intervention, supplementation with D5N and D5 significantly downregulated p16, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) expression and decreased SA-β-gal activity compared to the D1 group. …”

Table 2_Trends in immune cell profiles of osteomyelitis: a clinical study supported by Mendelian randomization analysis.docx by Zemin Liu (224306)

“…Subgroup analysis revealed significantly increased lymphocyte counts and decreased neutrophil counts across all subgroups, except for the mixed infection group. …”

Table 11_Burden of malaria in the Comoros, 1990–2021: findings from the global burden of disease study 2021.xlsx by Sheng Zhou (66217)

“…Analyzing the malaria burden will aid in designing prevention, control, and eradication strategies based on scientific evidence.</p>Methods<p>We retrieved data from the 2021 Global Burden of Disease (GBD) database to assess the malaria burden in the Comoros in 2021, stratified by sex and age. …”