Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation حسب Huang-Ju Tu (630766)

"…In this study, we utilised structure-based virtual screening (SBVS) from NCI library to discover novel DYRK1A inhibitors. …"

Data_Sheet_1_Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.PDF حسب Kate Beecher (6688340)

"…Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. …"

Predicting the potential distribution of <i>Arisaema heterophyllum</i> in China under current and future climate change based on ArcGIS and MaxEnt model حسب Jing Xu (15337)

"…<p>Climate change significantly affects the distribution of medicinal plants, necessitating accurate models to predict future shifts in their habitats. …"

OMT حسب Jingmin Ou (19669426)

"…OMT was found to significantly increase the apoptosis rate of endothelial cells (ECs) treated with oxidised low-density lipoprotein (ox-LDL), as measured by caspase-3 activity assay and flow cytometry. qRT-PCR results showed that OMT treatment decreased the expression of miR-199a-5p in ECs.Transfection of miR-199a-5p mimics enhanced the apoptotic effect, whereas miR-199a-5p inhibitors attenuated apoptosis, suggesting that miR-199a-5p has a key regulatory role in EC apoptosis. …"

Data Sheet 1_A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury.docx حسب Meiying Li (6051287)

"…In vitro, GO@GSH-FA significantly restored viability in oxygen-glucose-deprived SH-SY5Y cells (from 31% up to near control levels), reduced inflammatory cytokines, and lowered intracellular ROS. …"

Table3_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.docx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Table2_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.xlsx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Table7_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.docx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Age-Dependent Impacts of Lighting Conditions on Contrast Sensitivity and Subjective Visual Perception Focusing on Pupil Size and Crystalline Lens Transmittance حسب Taisuke Eto (17892397)

"…Log CS significantly decreased in older adults and increased with increasing illuminance, regardless of age group or CCT. …"

Table5_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.docx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

The relationship between HBV antigens deposition in kidneys and renal prognosis in IgA nephropathy patients infected with HBV حسب Yun Guo (135103)

"…The primary outcome was a composite of 30% decrease in eGFR from the baseline, kidney failure and all-cause mortality. …"

GluA1 promotes opioid use حسب Yuan-Yuan Hou (11896051)

"…In this study using a rat model of morphine self-administration (MSA), we found that short-term pain, induced by an intraplantar injection of complete Freund’s adjuvant, acutely decreased voluntary morphine intake, but not food intake, only at a morphine dose that did not affect pain itself. …"

Table4_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.xlsx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Table1_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.xlsx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Data Sheet 1_Study on the function of TTG1 gene in Camellia oleifera.docx حسب Chengcheng Xiang (5512442)

"…Heterologous expression resulted in: (1) significantly increased leaf trichome density (up to 114 trichomes/50 mm²); (2) enhanced seed anthocyanin accumulation (199–318% increase); and (3) substantial alterations in fatty acid composition, including 79% elevation in oleic acid (C18:1), 113% increase in gondoic acid (C20:1), 35% reduction in both linolenic (C18:3) and palmitic acids (C16:0), and 87% decrease in erucic acid (C22:1). …"

Image3_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.tif حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

From ice to flow: Tracing the transformation of glacial dissolved organic matter across a typical Tibetan Plateau glacier-lake-stream continuum حسب Yongqiang Zhou (11551027)

"…<p dir="ltr"><a href="" target="_blank">Mountain glaciers are melting at an accelerated rate due to global warming, thereby significantly altering proglacial and downstream hydrology</a>. …"

Table6_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.xlsx حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Image1_Multi-omics analysis provides insights into the mechanism underlying fruit color formation in Capsicum.tif حسب Zhao Song (7135202)

"…In this study, the light-yellow color observed in immature CSJ009 fruits compared to CSJ010 could be attributed to decreased chlorophyll and carotenoid pigments. Through integrated analysis of the transcriptome and metabolome of CSJ009 and CSJ010, we identified 23,930 differentially expressed genes (DEGs) and 345 differentially accumulated metabolites (DAMs). …"

Image 1_Emapalumab for severe cytokine release syndrome in solid tumor CAR-T: a case report.tif حسب Tyler Ruemmele (20972594)

"…The hemodynamic improvement was associated with a decrease in IFN-γ and CXCL10 levels but no other cytokines. …"