Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

“…Additionally, compound LP-65 demonstrated significant modulation of MEK and mTOR signaling activity in human glioma cells (D54) and human melanoma cells (A375), with a corresponding decrease in cellular proliferation and migration. …”

Coal seam combustion (a), (c) and infrared thermometry map (b), (d) in Fire Zone 1 and 3 (Republished from Desheng Xie under a CC BY license, with permission from Desheng Xie, orig... by Desheng Xie (21439869)

The restoration effect carried out in the early stage of (a) Fire Zone 1 and (b) Fire Zone 3 (Republished from Desheng Xie under a CC BY license, with permission from Desheng Xie,... by Desheng Xie (21439869)

Image1_Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality.tif by Yi Zhang (9093)

“…Furthermore, when stratified by sleep duration, moderate to severe depression group showed a great decrease in progressive motility (PR), total motility, concentration and total sperm count (TSC) as referred to normal group in participants with sleep duration less than 7 hours.…”

Multivariable logistic regression analysis of the relationship of the date of a PHC visit with new visits, types of health events, procedure, and outcome of visits. by Taizo Sakata (21567847)

Data Sheet 1_The “best practices for farming” successfully contributed to decrease the antibiotic resistance gene abundances within dairy farms.docx by Barbara Salerno (12894908)

“…Despite similar levels of antibiotic administration (based on veterinary prescription data from the sampled farms) in both sampling campaigns, the total abundance of selected ARGs, particularly bla_TEM and tetA, significantly decreased after the adoption of the farming guidelines.…”

LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility by Shilin Xu (1884217)

Data Sheet 1_Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence.docx by Juan Chen (61123)

“…</p>Conclusion<p>This study integrated meta-analysis, murine model validation, and single-cell transcriptomic profiling to demonstrate a significant reduction of BDNF in CKD. Furthermore, renal BDNF expression decreased locally, predominantly originating from proximal tubule cells, macrophages, and podocytes, possibly epigenetically inhibited by the upregulation of lnc RNA Bdnf-as.…”

The normal force between two particles with different equivalent diameters for P3: (a) hertznormal contact force; (b) normal viscous contact force. by Yongfeng Zhu (7361045)

Chromatograms proved the selectivity of the proposed method. Red line: tissue spiked at the LOQ level; green line: blank tissue. Panel A: SIM and SIMA; panel B: LOV and LOVA. by Ewa Paszkowska (21246702)

A brief illustration of the revisions between AJCC TNM eighth and ninth editions. by Aihong Zheng (20571034)

(A-C) Force versus drill depth and torque versus drill depth. by Marsel Ganeyev (21453399)

(a, b). The statistical error analyses for the models using the same dataset. by Fahd Saeed Alakbari (10701871)

Data. by Michael C. Payne (2664379)

“…Using a generalized estimating equation model that accounted for age, sex, bednet use, and sentinel site, we found no significant difference in the effectiveness of the two treatment approaches (p = 0.845 for Mf and p = 0.332 for CFA). …”

Deficiency of <i>Irg1</i> decreased lung neutrophils in mice during <i>M</i>. <i>pneumoniae</i> infection. by Cui Wang (141700)

Prescription data. by Dainty Ei (22265317)

“…</p><p>Conclusions</p><p>Our study demonstrated differentiated changes in psychotropic medication prescribing patterns during the COVID-19 pandemic in Sweden. We found a pandemic effect on nicotine dependence drug prescribing, which the key variables could not explain. …”

<i>Oenocarpus bacaba</i> palm tree (A) and fruit (B). by Eudes Alves Simões-Neto (19697968)

“…Serological cure was achieved in 34.6% of cases, and IgG titers decreased in 15.3%.</p><p>Conclusions and significance</p><p>We encountered several barriers in managing ACD, including population vulnerability, reliance on outdated diagnostic techniques, lack of standardized molecular biology methods, and limited therapeutic options. …”

(A) The incidence of OME in the VA group compared to the non-VA group. (B) The rate of tympanostomy tube insertion in the VA group and non-VA group. by Miki Kashiwagi (21439684)

Microhardness vs. depth diagram of sample No. 6 ( by Van-Thuc Nguyen (19469762)

“…The greatest hardness was 576 HV, with a case depth of 1200 μm. …”

Comparison of absolute and relative errors. by Lahoucine Tadoummant (21647670)

“…A significant reduction in both error types is observed, with the relative error |<i>X</i>_<i>r</i>| decreasing from approximately 10⁻¹ to 10⁻⁸. …”