Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras by Charles W. Parry (20966154)

“…Here we report the discovery of a novel series of reversible inhibitors that bind in an enlarged version of the switch I–II pocket with nanomolar affinities. …”

Raw data. by Camilla Albano (16446679)

“…Conversely, silencing FASN or applying FASN inhibitors (<i>i.e</i>., CMS121 and C75) markedly reduces the infectivity of newly released HSV-1 virions, suggesting that, while initial replication remains unaffected, FASN is crucial for maintaining virion structure and facilitating entry into host cells. Additionally, we show that a source of lipid-rich external factors provided by fetal bovine serum significantly increases HSV-1 infectivity. …”

HSV-1 infection modulates the fatty acid synthase. by Camilla Albano (16446679)

Data used to generate Fig 1. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Table 6. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Table 2. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Fig 3. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Fig 5. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Fig 2. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Fig 6. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Fig 4. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Table 5. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Data used to generate Table 3. by Pattamaporn Kittayapong (289542)

“…Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (<i>p</i> < 0.05). …”

Effect of SBS on rumen fermentation (n = 5). by Minghui Zhang (298745)

“…The results showed that: (1) Compared with the CON group, the dressing percentage and eye muscle area in the SBS24 group significantly increased (<i>P</i> < 0.05); (2) Compared with the CON group, the butyrate content and total fatty acid content inthe SBS24 group significantly increased (<i>P</i> < 0.05); (3) Compared with the CON group, the Simpson index of the SBS groups significantly increased (<i>P</i> < 0.05), while the Shannon index of the SBS12, SBS18, and SBS24 groups significantly decreased (<i>P</i> < 0.01). …”

Classification of bioactive substances in SBS. by Minghui Zhang (298745)

“…The results showed that: (1) Compared with the CON group, the dressing percentage and eye muscle area in the SBS24 group significantly increased (<i>P</i> < 0.05); (2) Compared with the CON group, the butyrate content and total fatty acid content inthe SBS24 group significantly increased (<i>P</i> < 0.05); (3) Compared with the CON group, the Simpson index of the SBS groups significantly increased (<i>P</i> < 0.05), while the Shannon index of the SBS12, SBS18, and SBS24 groups significantly decreased (<i>P</i> < 0.01). …”

OTU venn diagram. by Minghui Zhang (298745)

“…The results showed that: (1) Compared with the CON group, the dressing percentage and eye muscle area in the SBS24 group significantly increased (<i>P</i> < 0.05); (2) Compared with the CON group, the butyrate content and total fatty acid content inthe SBS24 group significantly increased (<i>P</i> < 0.05); (3) Compared with the CON group, the Simpson index of the SBS groups significantly increased (<i>P</i> < 0.05), while the Shannon index of the SBS12, SBS18, and SBS24 groups significantly decreased (<i>P</i> < 0.01). …”

PCR reaction system. by Minghui Zhang (298745)

“…The results showed that: (1) Compared with the CON group, the dressing percentage and eye muscle area in the SBS24 group significantly increased (<i>P</i> < 0.05); (2) Compared with the CON group, the butyrate content and total fatty acid content inthe SBS24 group significantly increased (<i>P</i> < 0.05); (3) Compared with the CON group, the Simpson index of the SBS groups significantly increased (<i>P</i> < 0.05), while the Shannon index of the SBS12, SBS18, and SBS24 groups significantly decreased (<i>P</i> < 0.01). …”

Nutritional composition of SBS (DM basis, %). by Minghui Zhang (298745)

“…The results showed that: (1) Compared with the CON group, the dressing percentage and eye muscle area in the SBS24 group significantly increased (<i>P</i> < 0.05); (2) Compared with the CON group, the butyrate content and total fatty acid content inthe SBS24 group significantly increased (<i>P</i> < 0.05); (3) Compared with the CON group, the Simpson index of the SBS groups significantly increased (<i>P</i> < 0.05), while the Shannon index of the SBS12, SBS18, and SBS24 groups significantly decreased (<i>P</i> < 0.01). …”

Risk of bias across 22 included studie. by Kuo-Chuan Hung (8587392)

“…</p><p>Results</p><p>A meta-analysis of 22 RCTs (n = 3,463) showed that ketamine/esketamine significantly decreased PPD risk at 1- (risk ratio [RR], 0.41; 95% confidence interval [CI], 0.3–0.57) and 4–6-week (RR, 0.47; 95%CI, 0.35–0.63) follow-ups. …”

An overview of the selection process for studies. by Kuo-Chuan Hung (8587392)

“…</p><p>Results</p><p>A meta-analysis of 22 RCTs (n = 3,463) showed that ketamine/esketamine significantly decreased PPD risk at 1- (risk ratio [RR], 0.41; 95% confidence interval [CI], 0.3–0.57) and 4–6-week (RR, 0.47; 95%CI, 0.35–0.63) follow-ups. …”